Antivirales (1)
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ANTIVIRALESANTIVIRALES
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• Clasificacion de los virus• DNA• RNA• PATOGENOS• NO PATOGENOS
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CLASIFICACIONINHIBICION DE LA ADSORCION Y
PENETRACION• GAMAGLOBULINA• AMANTADINA-RIMANTADINAINHBICION DE LA SINTESIS
INTRACELULARINHIBICON DEL ENSAMBLAJEOTROS
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OTRA• NO RETROVIRALES• Para herpes• Para Influenza• Para Hepatitis
• RETROVIRALES
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ACICLOVIR
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• ANALOGO DE GUANOSINA• INACTIVA DNA POLIMERASA• SE ACTIVA INATRACELULARMENTE• ORAL, IV Y TOPICO• POCA ABSORCION, ELIM.RENAL• TOPICO LIMITADA EFECTIVIDAD• RAMS:
NAUSEAS,OBS.TUBULAR,MOLESTIAS LOCALES,ENCEFALOPATIA
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OTROS RELACIONADOS• VALACICLOVIR---ACICLOVIR• FAMCICLOVIR---PENCICLOVIR• GANCICLOVIR( CITOMEGALOVIRUS)NEUTROPENIA,ANEMIA,CONVULSIONES,ALUCINACION
ES.IDOXIURIDINA• ANALOGO DE TIMIDINA• TIMIDINCINASA VIRAL• USO TOPICO• IRRITACION LOCAL
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TRIFLURIDINA• ANALOGO DE TIMIDINA FLUORADA• INHIBE TIMIDILATO SINTETASA-ADN
POLIMERASA VIRAL• TOPICA• EDEMA ,ARDORVIDARABINA• ANALOGO DE ADENOSINA• INHIBE POLIMERASA VIRAL• TOPICO• TGI-MANI.NEUROLOGICAS
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AMANTADINA RIMANTADINA• AMINAS CICLICAS• BLOQUEN DESPRENDIMIENTO DE
LA CUBIERTA VIRAL• INFLUENZA A• AMANTADINA—DOPAMINA• ORALES , DIF VIDA MEDIA• INSOMNIO,CONVULSIONES,TGI
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RIBAVIRINA• ANALOGO DE GAUNOSINA• INHIBE RNA POLIMERASA• TRSCRIPTASA INVERSA• INFLUENZA AY B, H C,V.SINCITIAL• ANEMIA,DEPRESION MED OSEA.FOSCARNET• PIROFOSFATO INORGANICO• INHIBE POLIMERASA VIRALDNA-RNA• SOLO IV-CMV, DEPO EN HUESO• INS RENAL,HIPOCALCEMIA,TOX
HEMATOLOGICA
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INTERFERONES• PROTEINAS ENDOGENAS• IFN-ALFA; IFN BETA,IFN GAMA• INHIBICION DE PENETRACION
VIRAL, PERDIDA DE LA CUBIERTA, INB DE RNA, ,ENSAMBLAJE Y LIBERACION
• HEPATITIS B Y C• NEUTROPENIA
,ANEMIA,SIN.CONSTITUCIONALES,CARDIOMIOPATIA
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TRATAMIENTO DE HIV
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CLASIFICACION
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INHIBIDORES DE TRANSCRIPTASA INVERSA
ZIDOVUDINA• ANALOGO DE TIMIDINA-ACTIVACION• ORAL,IV V ½ 1-1.5 H , MET HEPATICO• EMBARAZADAS Y NIÑOS• ANEMIA, NEUTROPENIA,CEFALEA,
MIALGIAS,NAUSEAS, INSOMNIO,HEPATOMEGALIA,MIOSITIS
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DIDANOSINA ---PANCRAETITISZALCITABINA---NEUROPATIAESTAVUDINA--NEUROPATIALAMIVUDINA
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INHIBIDORES DE PROTEASA
• INDINAVIR• RITONAVIR• SAQUINARBIEN TOLERADOSSINERGICOSCON LOS ITIREDUCEN RESISTENCIA
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Las recomendaciones internacionales y también en nuestro país para iniciar TARV , son las siguientes:
• Infección VIH sintomática: se recomienda inicio de terapia. • Infección VIH asintomática, con menos de 200 CD4 cels/ul: se recomienda inicio de terapia. • Infección VIH asintomática, con más de 200 y menos de 350 CD4 cels/ul: el inicio de terapia se debe
considerar, con base en la disminución del recuento absoluto de CD4 en el tiempo y en el nivel de carga viral (HIV-RNA).
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TRATAMIENTO• TRI O TETRACONJUGADOS
• INHIBIDOR DE PROTESA +INHIBIDOR DE TRASCRIPTASA
• DIFERENETES ESQUEMAS
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PROFILAXIS• ENTRE 6 Y 72 HORAS• LO MAS IMPORTANTE CLASIFICAR
EL RIESGO• SE EMPLEA SI ES ALTO O MEDIO. ZIDOVUDINA + LAMIVUDINA. ZIDOVUDINA+ LOPINAVIR-
SAQUINAVIR
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• TRANSMISION VERTICAL• IMPORTANTE ESTABLECER LA
CARGA VIRAL• ZIDOVUDINA+
LAMIVUDINA+NELFINAVIR
• ZIDOVUDINA-LAMIVUDINA+NEVIRAPINA
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• En terapia antiretroviral se esta inovando y escribiendo todo el tiempo
• Por esta razón lo mejor será indivisualizar