ER Stress Pathway · 2018-11-12 · Apoptosis ATF6 (p50) ATF6 (p90) IRE1 PERK IRE1 XBP1 mRNA...
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Apoptosis ATF6 (p50) ATF6 (p90) PERK IRE1 IRE1 XBP1 mRNA splicing ATF6 (p50) Mitochondria Endoplasmic reticulum Golgi apparatus Cytochrome C UPR genes (GRP78, PDI, GRP94, etc) Secretion ROS Proteasomal degradation ERSEs Unfolded protein Nucleus ATF6 (p90) Pro-caspase-12 Caspase12 Caspase 3 Bcl-2 JNK ATF4 PP1 GADD34 XBP1s EDEM Derlin elF-2α CHOP ATF4 XBP1s ASK1 P P P P P Kinase Phosphatase Transcription factor Ligand Kinase Key Translation ER stress pathway To find out more, please visit www.abcam.com Copyright © 2018 Abcam. All rights reserved
Transcript of ER Stress Pathway · 2018-11-12 · Apoptosis ATF6 (p50) ATF6 (p90) IRE1 PERK IRE1 XBP1 mRNA...
Apoptosis
ATF6(p50)
ATF6(p90)
PERKIRE1 IRE1
XBP1 mRNA splicing
ATF6(p50)
Mitochondria
Endoplasmicreticulum
Golgi apparatus
Cytochrome C
UPR genes (GRP78, PDI, GRP94, etc)
Secretion
ROSProteasomal degradation
ERSEs
Unfolded protein
Nucleus
ATF6 (p90)
Pro-caspase-12
Caspase12Caspase 3
Bcl-2 JNK
ATF4
PP1
GADD34XBP1s
EDEMDerlin
elF-2α
CHOP
ATF4 XBP1s
ASK1
PPP P P
Kinase
Phosphatase
Transcriptionfactor
Ligand
Kinase
Key
Translation
ER stress pathway
To find out more, please visit www.abcam.comCopyright © 2018 Abcam. All rights reserved