LES 2012 criterios
-
Upload
martina-alarcon-acevedo -
Category
Documents
-
view
12 -
download
0
description
Transcript of LES 2012 criterios
![Page 1: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/1.jpg)
Guillermo Ruiz-Irastorza
Unidad de Investigación de Enfermedades Autoinmunes
Servicio de Medicina Interna
Hospital Universitario Cruces
Universidad del País Vasco / Euskal Herriko Unibertsi tateaUNIDAD DE INVESTIGACIÓN DE
ENFERMEDADES AUTOINMUNES
LOS NUEVOS CRITERIOS CLASIFICATORIOS DEL LES
SLICC 2012
![Page 2: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/2.jpg)
ES LUPUS ??
![Page 3: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/3.jpg)
ES LUPUS ??
![Page 4: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/4.jpg)
1971
![Page 5: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/5.jpg)
1971
4 de 14
![Page 6: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/6.jpg)
1982
![Page 7: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/7.jpg)
4 de 11
1982
![Page 8: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/8.jpg)
1997
![Page 9: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/9.jpg)
4 de 11
1997
![Page 10: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/10.jpg)
PROBLEMAS DE LOS CRITERIOS ACR
Excesivo peso de la piel (3/11)
No es imprescindible la inmunología
Nefritis lúpica aislada
Complemento
![Page 11: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/11.jpg)
![Page 12: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/12.jpg)
![Page 13: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/13.jpg)
![Page 14: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/14.jpg)
![Page 15: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/15.jpg)
![Page 16: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/16.jpg)
![Page 17: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/17.jpg)
4/17 (CLINICAL AND IMMUNOLOGIC)
OR
BIOPSY-PROVEN LUPUS NEPHRITIS PLUS ANA / ANTI-DNA
![Page 18: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/18.jpg)
2003: Revisión de posibles variables
DERIVATION SET: 716 PACIENTES
SLE (n 293), RA (n 119), myositis (n 55), chronic cutaneous lupus (n 50), undifferentiated connective tissue disease (n 44), vasculitis (n 37), primary APS (n 33), scleroderma (n 28), fibromyalgia (n 25), Sjogren’s syndrome (n 15), rosacea (n 8), psoriasis (n 7), sarcoidosis (n 1), and JIA (n 1).
Identificación de variables y discusión del set final: n=17
VALIDATION SET: 690 PACIENTES
SLE (n 337), RA (n 118), undifferentiated connective tissue disease (n 89), primary APS (n 30), vasculitis (n 29), chronic cutaneous lupus (n 24), scleroderma (n 20), Sjogren’s syndrome (n 15), myositis (n 14), psoriasis (n 8), fibromyalgia (n 4), alopecia areata (n 1), and sarcoidosis (n 1).
![Page 19: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/19.jpg)
![Page 20: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/20.jpg)
2003: Revisión de posibles variables
DERIVATION SET: 716 PACIENTES
SLE (n 293), RA (n 119), myositis (n 55), chronic cutaneous lupus (n 50), undifferentiated connective tissue disease (n 44), vasculitis (n 37), primary APS (n 33), scleroderma (n 28), fibromyalgia (n 25), Sjogren’s syndrome (n 15), rosacea (n 8), psoriasis (n 7), sarcoidosis (n 1), and JIA (n 1).
Identificación de variables y discusión del set final: n=17
VALIDATION SET: 690 PACIENTES
SLE (n 337), RA (n 118), undifferentiated connective tissue disease (n 89), primary APS (n 30), vasculitis (n 29), chronic cutaneous lupus (n 24), scleroderma (n 20), Sjogren’s syndrome (n 15), myositis (n 14), psoriasis (n 8), fibromyalgia (n 4), alopecia areata (n 1), and sarcoidosis (n 1).
590 (86%) con 80% de acuerdo en primera vuelta (12 miembros)
100 (14%) a segunda vuelta (33 miembros)
![Page 21: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/21.jpg)
![Page 22: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/22.jpg)
![Page 23: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/23.jpg)
GOLD STANDARD
![Page 24: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/24.jpg)
CLASIFICACIÓN vs.
DIAGNÓSTICO
![Page 25: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/25.jpg)
CLASIFICACIÓN...
DECEPCIÓN ?
![Page 26: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/26.jpg)
DIAGNÓSTICO...
EL FUTURO ?
![Page 27: LES 2012 criterios](https://reader038.fdocuments.co/reader038/viewer/2022102915/563db847550346aa9a923a86/html5/thumbnails/27.jpg)