Ototoxicidad
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Transcript of Ototoxicidad
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OtotoxicidadDr Carlos Augusto Ceballos Sabido
R1 Otorrinolaringología y Cirugía de Cabeza y Cuello
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Ototoxicidad sistémica
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AminoglucósidosEstreptomicina en 1943 por Waksman
Acción contra Pseudomonas y bacilos Gram –
Costo bajo
Diferentes opciones terapéuticas
Terapia de segunda/tercera linea
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“micyn” = Strptomyces
“micin” = Micromonospora
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Causa más común de disfunción vestibular bilateral
Poco común tener cocleotoxicidad y vestibulotoxicidad simulatneas
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PlatinoInhibidores selectivos de la replicación de DNA no selectivos de ciclo celular
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Nedaplatino: Menos toxicidad que Cisplatino pero más que CarboplatinoOxaliplatino: Sin ascoiación con Nefro/ototoxicidad
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Alcaloides de Vinca
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Diuréticos de asaRiesgo por prematurez, alteración renal y uso concomitante de aminoglucósidos
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MacrólidosRiesgo por compromiso hepático, renal o en transplantadosAzitromicina en px con VIH
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VancomicinaRiesgo aumentado en neonatos, uso de aminoglucósidos y extremos de la vida
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ASA y salicilatos11:1000Tinnitus y HL leve a moderada, reversibleCese en 24-72hsQuinina: similar a ASA
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Quelantes de hierro
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Ototoxicidad tópica
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Soluciones óticasDemostrado en animales; debatido en humanosAcceso por ventana redondaUso intencionado de Gentamicina
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Otros ototóxicos tópicos:ClorhexidinaCloranfenicolAlcohol
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Genética
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Genética
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Antioxidantes
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