Presentación de PowerPoint · ERp57) and binds to TAP via tapasin Cytosolic proteins md defective...
Transcript of Presentación de PowerPoint · ERp57) and binds to TAP via tapasin Cytosolic proteins md defective...
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RECONOCIMIENTO RESPUESTA
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LA INMUNIDAD INNATA
Cada tipo celular responderá en función de sus propias capacidades
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¿ QUÉ RECONOCEN LAS CÉLULAS DE LA INMUNIDAD INNATA?
PATRONES MOLECULARES ASOCIADOS A PATÓGENOS
¿ CÓMO LOS RECONOCEN ?
PATRONES MOLECULARES ASOCIADOS A DAÑO
A TRAVÉS DE LOS RRP
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¿ QUÉ RECONOCEN LAS CÉLULAS DE LA INMUNIDAD ADAPTATIVA?
ANTÍGENOS
RECEPTOR B o BCR RECEPTOR T o TCR
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¿ CUÁNTOS RECEPTORES HAY ?
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¿ CÓMO SE GENERAN LOS RECEPTORES ?
RECOMBINACIÓN SOMÁTICA
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¿DÓNDE GENERAN SUS RECEPTORES LOS LINFOCITOS T Y B Y CÓMO SE LLAMA ESE PROCESO?
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¿ QUÉ TIENE DE ESPECIAL LA INMUNIDAD ADAPTATIVA?
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PRIMER ENCUENTRO CON UN ANTÍGENO
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SEGUNDO ENCUENTRO CON UN ANTÍGENO
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A MEDIDA QUE PASA EL TIEMPO, LA CANTIDAD DE LINFOCITOS QUE
RESPONDEN A UN ANTÍGENO ESPECÍFICO , AUMENTA
LA PROBABILIDAD DE QUE SE DE EL ENCUENTRO CON EL ANTÍGENO ES CADA VEZ MAYOR Y MÁS RÁPIDA.
EXPANSIÓN CLONAL
MEMORIA
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LOS LINFOCITOS B RECONOCEN EL ANTÍGENO DE FORMA SOLUBLE
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NO OCURRE LO MISMO PARA LOS LINFOCITOS T
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CMH I CMH II
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MUCHOS PATÓGENOS REPLICAN DENTRO DE LAS CÉLULAS
PRESENTACIÓN POR CMH I
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POLIMORFISMOS
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Zinkernagel, Rolf Martin
EXPERIMENTO
Peter Doherty
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RESTRICCIÓN POR CMH
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POLIMORFISMO Y ENFERMEDAD CELÍACA
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