Tema 29-1 Colesterol.ppt
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Transcript of Tema 29-1 Colesterol.ppt
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¡ Lípido de los tejidos animales !¡ Lípido de los tejidos animales !
- membranas celulares
- Precursor de sales biliares
- Precursor de hormonas esteroideas
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colesterol
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- Citosol
- Enzimas microsomales
Localización tisular:
Localización subcelular:
Todos los tejidos
Síntesis endógena de colesterolSíntesis endógena de colesterol
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Biosíntesis
ATP
NADPH
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colesterol
Ácido mevalónicoAcetil CoAHMGCoA HMGCoA reductasareductasa
NADPHNADPH
NADPHNADPH
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Formación de mevalonatoFormación de mevalonato
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2CH3 – C - SCoA β-cetotiolasa CoASH + acetoacetilCoA
CH3CCH2CO S-CoA
O
CH3CCH2CO S-CoA
OHCH2
CO O
CH3C S-CoA
O
+ H2O
CH3CCH2CH2OH
OHCH2
CO O
2 NADPH2 NADP++ CoA-SH
mevalonato
HMG-CoA sintasa
HMG-CoA
HMG-CoA reductasaHMG-CoA reductasa
O
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Esterificación del colesterolEsterificación del colesterol
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Reductasa
- fluidez de la membrana
- retroinhibición
- regulación hormonal
Entrada de colesterol a las células
- Alimentación (hígado)
- receptor de LDL
Regulación de la biosíntesis de Regulación de la biosíntesis de colesterolcolesterol
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modificación de la fluidez
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regulación covalente y hormonal
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retroinhibición
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colesterol
Ácido mevalónicoAcetil CoAHMGCoA HMGCoA reductasareductasa
LDLAlimentación(hígado)
Entrada de colesterol a las células
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HDL
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¿Cómo se puede controlar el exceso de colesterol que no es retirado fisiológicamente?
- Ingestión de resinas
- Tratamiento con estatinas
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¿Cómo se controla el exceso de colesterol?
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a)
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Destino del colestrolDestino del colestrol
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Colesterol
- hormonas esteroideas
- ácidos biliares
- productos de reducción
(que se excretan)
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cis A y B
trans A y B