UNIVERSIDAD DEL VALLE DE MÉXICO
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Transcript of UNIVERSIDAD DEL VALLE DE MÉXICO
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UNIVERSIDAD DEL VALLE DE MÉXICO
Matriz Extracelular
DR. GERARDO CANCINO BALCÁZAR
DIVISIÓN DE CIENCIAS DE LA SALUD
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Matriz extracelular
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Matriz extracelular
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Tejido Conectivo
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Tejido Conectivo
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Matriz extracelular
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Matriz extracelular
Cornea de rata
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Glucosaminoglucanos
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Glucosaminoglucanos
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Hialurona
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Hialurona
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Proteoglicanos
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Proteoglicanos
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Proteoglicanos
Quimiocinas e inflamación
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Proteoglicanos
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Proteoglicanos
Cartílago de rata
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ProteoglicanosPROTEOGLYCAN APPROXIMATE
MOLECULAR WEIGHT OF CORE PROTEIN
TYPE OF GAG CHAINS NUMBER OF GAG CHAINS
LOCATION FUNCTIONS
Aggrecan 210,000 chondroitin sulfate + keratan sulfate
~130 cartilage mechanical support; forms large aggregates with hyaluronan
Betaglycan 36,000 chondroitin sulfate/ dermatan sulfate
1 cell surface and matrix
binds TGF-β
Decorin 40,000 chondroitin sulfate/ dermatan sulfate
1 widespread in connective tissues
binds to type I collagen fibrils and TGF-β
Perlecan 600,000 heparan sulfate 2–15 basal laminae structural and filtering function in basal lamina
Syndecan-1 32,000 chondroitin sulfate + heparan sulfate
1–3 epithelial cell surface cell adhesion; binds FGF and other growth factors
Dally (in Drosophila) 60,000 heparan sulfate 1–3 cell surface co-receptor for Wingless and Decapentaplegic signaling proteins
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Colagena
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Colagena
Migración de fibroblastos en colagena
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Elastina
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Elastina
Aorta de perro
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Elastina
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Fibronectina
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Fibronectina
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Fibronectina Actina
Actina regula el ensamble de fibras de fibronectina
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Lamina Basal
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Lamina Basal
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Lamina Basal
Cornea de embrión de pollo
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ECM media la migración celular
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ECM media la migración celular
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Metaloproteasas