第 1 条,共 86 条 标题: Effects of Intracellular Superoxide Removal at Acupoints with TAT-SOD on Obesity 作者: Guo, JK (Guo, Jingke); Chen, Y (Chen, Yue); Yuan, B (Yuan, Bin); Liu, ST (Liu, Shutao);
Rao, PF (Rao, Pingfan) 来源出版物 : FREE RADICAL BIOLOGY AND MEDICINE 卷 : 51 期 : 12 页 :
2185-2189 DOI: 10.1016/j.freeradbiomed.2011.09.036 出版年: DEC 15 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 26 摘要: TAT-SOD is a recombinant protein of superoxide dismutase fused with TAT peptide. By
pure accident, we discovered that topical application of TAT-SOD to acupoints could result in
acupuncture-like action. This study aimed to validate the accidental discovery by investigating the
effect on simple obesity of the topical application of TAT-SOD to acupoints in comparison with
acupuncture. 90 subjects were divided into 3 groups for 12-week treatments. Regular hospital
acupuncture treatment was given to Acupuncture Group 3 times a week. TAT-SOD Group were
instructed first to locate acupoints and apply 0.1 ml of 5000u SOD/ml TAT-SOD cream in an area
of 1 cm(2) to each of the same set of acupoints, which they then conducted at home three times
daily. Placebo Group applied the vehicle cream the same manner as TAT-SOD Group. Both
TAT-SOD and acupuncture treatments decreased adiposity with overall clinical effective rates of
60.0% and 76.7%, respectively. The placebo group showed no improvement. The results validate
that the enzymatic removal of the intracellular superoxide at acupoints could generate
acupuncture-like effects, and indicate a possibility of the new method as a simple substitute to
acupuncture and an insight of superoxide modulation along meridians for acupuncture mechanism.
(C) 2011 Elsevier Inc. All rights reserved. 入藏号: WOS:000297960000007 语种: English 文献类型: Article 作者关键词: Superoxide; TAT-SOD; Acupuncture; Meridian; Simple obesity; Free radicals
KeyWords Plus: APPETITE SUPPRESSION; PROTEIN; ACUPUNCTURE; DISMUTASE;
TRANSDUCTION; METAANALYSIS; CELLS 地址: [Guo, Jingke; Liu, Shutao; Rao, Pingfan] Fuzhou Univ, Inst Biotechnol, Fuzhou 350002,
Fujian, Peoples R China
[Chen, Yue; Yuan, Bin] Fujian Univ Tradit Chinese Med, Acupuncture Coll, Fuzhou, Fujian,
Peoples R China 通讯作者地址: Rao, PF (通讯作者),Fuzhou Univ, Inst Biotechnol, 523 Gongye Rd, Fuzhou
350002, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: ELSEVIER SCIENCE INC 出版商地址: 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Web of Science 分类: Biochemistry & Molecular Biology; Endocrinology & Metabolism 学科类别: Biochemistry & Molecular Biology; Endocrinology & Metabolism
IDS 号: 860PK
ISSN: 0891-5849
29 字符的来源出版物名称缩写: FREE RADICAL BIO MED
ISO 来源出版物缩写: Free Radic. Biol. Med. 来源出版物页码计数: 5 基金资助致谢: 基金资助机构 授权号
National Basic Research Program of China 2010CB530605
National Natural Science Foundation of China 30973871
31071497
Fujian Science and Technology Bureau 2008Y0088
Education Council of Fujian Province of China JB09154
Fuzhou University, China 2010-XY-17
We Thank Du Jian and Dou Sidong of Fujian University of Tradional Chinese Medicine for
helpful discussions. This research was supported by National Basic Research Program of China
(Grant No. 2010CB530605); National Natural Science Foundation of China (Grant No. 30973871,
No. 31071497); Key Research Program of Fujian Science and Technology Bureau (Grant No.
2008Y0088); Education Council of Fujian Province of China (Grant No. JB09154); Science and
Technology Development Fund of Fuzhou University, China (Grant No. 2010-XY-17).
第 2 条,共 86 条 标题: Anti-angiogenic effect of Spica prunellae extract in vivo and in vitro 作者: Lin, W (Lin, Wei); Zheng, LP (Zheng, Liangpu); Zhao, JY (Zhao, Jinyan); Zhuang, QC
(Zhuang, Qunchuan); Hong, ZF (Hong, Zhenfeng); Xu, W (Xu, Wei); Chen, YQ (Chen, Youqin);
Sferra, TJ (Sferra, Thomas J.); Peng, J (Peng, Jun) 来源出版物: AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY 卷: 5 期:
24 页: 2647-2654 DOI: 10.5897/AJPP11.266 出版年: DEC 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 35 摘要: Angiogenesis is a fundamental component of cancer growth and metastasis; therefore,
inhibition of angiogenesis has become a promising strategy for the discovery and development of
cancer chemotherapeutics. Recently, natural products have attracted significant interest as
therapeutic agents for cancer since they have relatively fewer side effects as compared to modern
chemotherapeutics and have long been used clinically to treat a variety of diseases, including
cancer. Spica prunellae is an important component in several traditional Chinese medicine (TCM)
formulations for cancer treatment. Recently, we reported that S. prunellae inhibits cancer cell
growth through the induction of mitochondrion-dependent apoptosis. However, the precise
mechanisms of its overall anti-cancer activity remain largely unknown. In the present study, we
investigated the anti-angiogenic effects of the ethanol extract of S. prunellae (EESP) in vitro on
human umbilical vein endothelial cells (HUVECs) and in vivo using the chick embryo
chorioallantoic membrane (CAM) assay. We found that EESP inhibited the proliferation of
HUVECs via blockade of cell cycle G1 to S progression. In addition, EESP inhibited the
migration and tube formation of HUVECs. Moreover, EESP treatment decreased VEGF-A
expression in HT-29 human colon carcinoma cells as well as the expression of VEGF-A and
VEGFR-2 in HUVECs. Furthermore, EESP exposure reduced the formation of blood vessels in
chick embryos. These results suggest that the inhibition of angiogenesis is one of the mechanisms
by which S. prunellae can mediate an anti-cancer effect. 入藏号: WOS:000299679300002 语种: English 文献类型: Article 作者关键词: Spica prunellae; angiogenesis; cancer treatment; herbal medicine
KeyWords Plus: ENDOTHELIAL GROWTH-FACTOR; TUMOR ANGIOGENESIS;
THERAPEUTIC IMPLICATIONS; COLORECTAL-CANCER; FACTOR EXPRESSION;
NATURAL-PRODUCTS; DRUG-RESISTANCE; METASTASIS; CARCINOMA; PROGNOSIS 地址: [Lin, Wei; Zheng, Liangpu; Zhao, Jinyan; Zhuang, Qunchuan; Hong, Zhenfeng; Peng, Jun]
Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China
[Zheng, Liangpu] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med Geriatr, Fuzhou
350108, Fujian, Peoples R China
[Xu, Wei] Fujian Univ Tradit Chinese Med, Dept Pharmacol, Fuzhou 350108, Fujian, Peoples R
China
[Chen, Youqin; Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Paediat, Oklahoma City,
OK 73190 USA
[Chen, Youqin; Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol,
Oklahoma City, OK 73190 USA 通讯作者地址: Peng, J (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, 1
Huatuo Rd, Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
Web of Science 分类: Pharmacology & Pharmacy 学科类别: Pharmacology & Pharmacy
IDS 号: 884BG
ISSN: 1996-0816
29 字符的来源出版物名称缩写: AFR J PHARM PHARMACO
ISO 来源出版物缩写: Afr. J. Pharm. Pharmacol.
来源出版物页码计数: 8 基金资助致谢: 基金资助机构 授权号
Natural Science Foundation of Fujian province of China 2009J01173
Research Foundation of Education Bureau of Fujian province of China JA10168
National Natural Science Foundation of China 81073097
Developmental Fund of Chen Keji Integrative Medicine CKJ 2010019
This work was sponsored by the Natural Science Foundation of Fujian province of China
(2009J01173), the Research Foundation of Education Bureau of Fujian province of China
(JA10168), the National Natural Science Foundation of China (81073097) and the Developmental
Fund of Chen Keji Integrative Medicine (CKJ 2010019).
第 3 条,共 86 条 标题: A comparative study on antioxidant activity of ten different parts of Nelumbo nucifera
Gaertn. 作者: Wu, YB (Wu, Yan-Bin); Zheng, LJ (Zheng, Li-Jun); Yi, J (Yi, Jun); Wu, JG (Wu, Jian-Guo);
Tan, CJ (Tan, Chun-Jiang); Chen, TQ (Chen, Ti-Qiang); Wu, JZ (Wu, Jin-Zhong); Wong, KH
(Wong, Ka-Hing) 来源出版物: AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY 卷: 5 期:
22 页: 2454-2461 DOI: 10.5897/AJPP11.352 出版年: DEC 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 27 摘要: The in vitro antioxidant activity of ten different parts of lotus (Nelumbo nucifera Gaertn.)
was evaluated and compared. Among the ten lotus extracts, the receptacle did not only possessed
the highest phenolic, flavonoid and proanthocyanidin contents, but its 2-picrylhydrazyl free
(DPPH) and 2, 2'-Azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging
activities, reducing power as well as total antioxidant activity were also comparable to, if not
better than those of the butylated hydroxytoluene (BHT) control (p < 0.05). Compared with the
BHT, all ten lotus extracts even exhibited significantly (p < 0.05) higher metal chelating activity.
Nevertheless, the hydroxyl radical scavenging ability of all ten lotus extracts was significantly (p
< 0.05) lower than that of the ascorbic acid control. In contrast to the metal chelating ability,
phenolic compounds in the ten lotus extracts would likely be responsible for their DPPH and
ABTS radical scavenging activities. 入藏号: WOS:000299677200005 语种: English 文献类型: Article 作者关键词: Louts (Nelumbo nucifera); total phenolic content; total flavonoid content; total
proanthocyanidin content; antioxidant activity
KeyWords Plus: IN-VITRO; LEAVES; FLAVONOIDS; EXTRACTS; STAMENS; MICE 地址: [Wu, Yan-Bin; Zheng, Li-Jun; Wu, Jian-Guo; Tan, Chun-Jiang; Wu, Jin-Zhong] Fujian Univ
Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China
[Yi, Jun] Fujian Inst Educ, Dept Chem & Life Sci, Fuzhou 350001, Fujian, Peoples R China
[Chen, Ti-Qiang] Fujian Acad Agr Sci, Inst Edible & Med Fungi, Fuzhou 350013, Peoples R
China
[Wong, Ka-Hing] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong
Kong, Peoples R China 通讯作者地址: Wu, JZ (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou
350108, Fujian, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
Web of Science 分类: Pharmacology & Pharmacy 学科类别: Pharmacology & Pharmacy
IDS 号: 884AL
ISSN: 1996-0816
29 字符的来源出版物名称缩写: AFR J PHARM PHARMACO
ISO 来源出版物缩写: Afr. J. Pharm. Pharmacol. 来源出版物页码计数: 8 基金资助致谢: 基金资助机构 授权号
Fujian Provincial Universities for Haixi Development 5
Research Foundation of Health Bureau of Fujian Province of China wzzd0901
Developmental Fund of Chen Keji Integrative Medicine CKJ2010027
Natural Science Foundation of Fujian province of China 2011J01212
This work was conducted in Class III Laboratory of Traditional Chinese Medicine on
Pharmacognosy of State Administration of Traditional Chinese Medicine of People's Republic of
China and was financially supported by Key Project of Fujian Provincial Universities for Haixi
Development (Grant No. 5), the Research Foundation of Health Bureau of Fujian Province of
China (Grant No. wzzd0901), Developmental Fund of Chen Keji Integrative Medicine (Grant No.
CKJ2010027) as well as the Natural Science Foundation of Fujian province of China (Grant No.
2011J01212).
第 4 条,共 86 条 标题: Comparing different physical factors on serum TNF-alpha levels, chondrocyte apoptosis,
caspase-3 and caspase-8 expression in osteoarthritis of the knee in rabbits 作者: Guo, H (Guo, Hua); Luo, QL (Luo, Qinglu); Zhang, JL (Zhang, Jinlong); Lin, HD (Lin,
Haidan); Xia, L (Xia, Lu); He, CQ (He, Chengqi) 来 源 出 版 物 : JOINT BONE SPINE 卷 : 78 期 : 6 页 : 604-610 DOI:
10.1016/j.jbspin.2011.01.009 出版年: DEC 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 35 摘要: Objective: To study the therapeutic effects that different physical factors may have on
rabbits with osteoarthritis of the knee.
Methods: A total of 64 rabbits were randomised and organised into eight groups, eight of which
were each assigned a different physical factor, in which the rabbits received one type of physical
therapy: millimetre waves for 20 min, pulsed electromagnetic fields, millimetre waves for 40 min,
ultrasound, low-level laser therapy or ultrashort wave diathermy. The two remaining groups, the
normal group and the model group, served as controls. The efficacy of the different treatments
were determined by observing the configuration and structure of the cartilaginous tissue by
haematoxylin and Eosin staining, measuring the serum tumour necrosis factor-alpha levels by
enzyme immunoassay, evaluating the expression levels of caspases-3 and -8 by
immunohistochemistry, and calculating the ratio of chondrocytes apoptosis by TdT-mediated
dUTP nick end labelling. The values obtained for each assessment of the eight groups were
analysed by a One-way ANOVA.
Results: By applying upmentioned physical treatments, the organisational configuration and
structure of cartilage cells from the knees of rabbits with osteoarthritis increased. These treatments
also decreased serum tumour necrosis factor-alpha levels, reduced the expression of caspase-3 and
caspase-8 and reduced chondrocyte apoptosis, resulting in an overall delay in osteoarthritis
development.
Conclusion: The application of pulsed electromagnetic fields, millimetre waves for 40 min,
ultrasound, or low-level laser therapy had significant effects in improving osteoarthritis; in
particular, treatment with pulsed electromagnetic fields or ultrasound yielded the greatest
therapeutic effect. (C) 2011 Societe francaise de rhumatologie. Published by Elsevier Masson
SAS. All rights reserved. 入藏号: WOS:000298148300015 语种: English 文献类型: Article 作者关键词: OA; TNF-alpha; Chondrocyte apoptosis; Caspase-3; Caspase-8
KeyWords Plus: MILLIMETER WAVES; BIOPHYSICAL STIMULATION; CARTILAGE;
THERAPY; INTERLEUKIN-1-BETA; PHONOPHORESIS; ULTRASOUND; RECEPTORS;
PATHWAY; DEATH 地址: [Guo, Hua; Luo, Qinglu; Zhang, Jinlong; Lin, Haidan; Xia, Lu; He, Chengqi] Sichuan Univ,
W China Hosp, Dept Rehabil Med, Chengdu 610041, Sichuan Provinc, Peoples R China
[He, Chengqi] Rehabil Key Lab Sichuan Prov, Chengdu, Peoples R China
[Luo, Qinglu] Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R China
通讯作者地址: He, CQ (通讯作者),Sichuan Univ, Huaxi Hosp, Chengdu 610041, Sichuan
Provinc, Peoples R China 电子邮件地址: [email protected] 出版商: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER 出版商地址: 23 RUE LINOIS, 75724 PARIS, FRANCE
Web of Science 分类: Rheumatology 学科类别: Rheumatology
IDS 号: 863FN
ISSN: 1297-319X
29 字符的来源出版物名称缩写: JOINT BONE SPINE
ISO 来源出版物缩写: Joint Bone Spine 来源出版物页码计数: 7 基金资助致谢: 基金资助机构 授权号
National Natural Science Fund 30672215
We thank Yuqing Wang for the statistical and data analysis. We thank the National Natural Science
Fund (No. 30672215) for the financial support.
第 5 条,共 86 条 标题: Extraction of Lepidium apetalum Seed Oil Using Supercritical Carbon Dioxide and
Anti-Oxidant Activity of the Extracted Oil 作者: Xu, W (Xu, Wei); Chu, KD (Chu, Kedan); Li, H (Li, Huang); Chen, LD (Chen, Lidian);
Zhang, YQ (Zhang, Yuqin); Tang, XC (Tang, Xuchong) 来 源 出 版 物 : MOLECULES 卷 : 16 期 : 12 页 : 10029-10045 DOI:
10.3390/molecules161210029 出版年: DEC 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 30 摘要: The supercritical fluid extraction (SFE) of Lepidium apetalum seed oil and its anti-oxidant
activity were studied. The SFE process was optimized using response surface methodology (RSM)
with a central composite design (CCD). Independent variables, namely operating pressure,
temperature, time and flow rate were evaluated. The maximum extraction of Lepidium apetalum
seed oil by SFE-CO(2) (about 36.3%) was obtained when SFE-CO(2) extraction was carried out
under the optimal conditions of 30.0 MPa of pressure, 70 degrees C of temperature, 120 min of
extraction time and 25.95 L/h of flow rate. GC-MS analysis showed the presence of four fatty
acids in Lepidium apetalum seed oil, with a high content (91.0%) of unsaturated fatty acid. The
anti-oxidant activity of the oil was assessed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH)
radical-scavenging assay and 2,2'-azinobis(3-ethylbenzthiazoline-6-sulphonic acid) diammonium
salt (ABTS) test. Lepidium apetalum seed oil possessed a notable concentration-dependent
antioxidant activity, with IC(50) values of 1.00 and 3.75 mg/mL, respectively. 入藏号: WOS:000298411200019 语种: English 文献类型: Article 作者关键词: Lepidium apetalum; response surface methodology; supercritical fluid extraction;
GC-MS; anti-oxidant activity
KeyWords Plus: RESPONSE-SURFACE METHODOLOGY; FLUID EXTRACTION;
OPTIMIZATION; CAPACITY 地址: [Xu, Wei; Chu, Kedan; Li, Huang; Chen, Lidian; Zhang, Yuqin] Fujian Univ Tradit Chinese
Med, Coll Pharm, Fuzhou 350108, Peoples R China
[Tang, Xuchong] Hua Chiao Univ, Inst Chem Technol, Xiamen 361021, Peoples R China 通讯作者地址: Chen, LD (通讯作者),Fujian Univ Tradit Chinese Med, Coll Pharm, Fuzhou
350108, Peoples R China 电子邮件地址: [email protected] 出版商: MDPI AG 出版商地址: POSTFACH, CH-4005 BASEL, SWITZERLAND
Web of Science 分类: Chemistry, Organic 学科类别: Chemistry
IDS 号: 866UQ
ISSN: 1420-3049
29 字符的来源出版物名称缩写: MOLECULES
ISO 来源出版物缩写: Molecules 来源出版物页码计数: 17 基金资助致谢: 基金资助机构 授权号
Key Project of Fujian Province Science-Technology Department 2009YZ0001-1-1
Fujian Province Science-Technology Plan projects 2010Y2004
Xiuping Chen of ICMS
The authors gratefully acknowledge the financial support by a Key Project of Fujian Province
Science-Technology Department (2009YZ0001-1-1) and Fujian Province Science-Technology
Plan projects (2010Y2004). At the same time they acknowledge the support of Xiuping Chen of
ICMS in the experiments.
第 6 条,共 86 条 标题: Subtleties of biomineralisation revealed by manipulation of the eggshell membrane 作者: Li, N (Li, Nan); Niu, LN (Niu, Li-na); Qi, YP (Qi, Yi-pin); Yiu, CKY (Yiu, Cynthia K. Y.);
Ryou, H (Ryou, Heonjune); Arola, DD (Arola, Dwayne D.); Chen, JH (Chen, Ji-hua); Pashley, DH
(Pashley, David H.); Tay, FR (Tay, Franklin R.) 来 源 出 版 物 : BIOMATERIALS 卷 : 32 期 : 34 页 : 8743-8752 DOI:
10.1016/j.biomaterials.2011.08.007 出版年: DEC 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 35 摘要: Biocalcification of collagen matrices with calcium phosphate and biosilicification of diatom
frustules with amorphous silica are two discrete processes that have intrigued biologists and
materials scientists for decades. Recent advancements in the understanding of the mechanisms
involved in these two biomineralisation processes have resulted in the use of biomimetic strategies
to replicate these processes separately using polyanionic, polycationic or zwitterionic analogues of
extracellular matrix proteins to stabilise amorphous mineral precursor phases. To date, there is a
lack of a universal model that enables the subtleties of these two apparently dissimilar
biomineralisation processes to be studied together. Here, we utilise the eggshell membrane as a
universal model for differential biomimetic calcification and silicification. By manipulating the
eggshell membrane to render it permeable to stabilised mineral precursors, it is possible to
introduce nanostructured calcium phosphate or silica into eggshell membrane fibre cores or
mantles. We provide a model for infiltrating the two compartmental niches of a biopolymer
membrane with different intrafibre minerals to obtain materials with potentially improved
structure-property relationships. (C) 2011 Elsevier Ltd. All rights reserved. 入藏号: WOS:000296113500001 语种: English 文献类型: Article 作者关键词: Apatite; Biomineralisation; Silica; Membrane
KeyWords Plus: STABILIZED ORTHOSILICIC ACID; EXTRACELLULAR-MATRIX;
COLLAGEN; MINERALIZATION; BIOSILICIFICATION; MODEL; HEN 地址: [Pashley, David H.; Tay, Franklin R.] Georgia Hlth Sci Univ, Sch Grad Studies, Augusta,
GA 30912 USA
[Li, Nan] Fujian Univ Tradit Chinese Med, Coll Osteoped & Traumatol, Fuzhou, Peoples R China
[Niu, Li-na; Chen, Ji-hua] Fourth Mil Med Univ, Sch Stomatol, Dept Prosthodont, Xian 710032,
Peoples R China
[Qi, Yi-pin] Sun Yat Sen Univ, Guanghua Sch Stomatol, Guangzhou, Guangdong, Peoples R
China
[Yiu, Cynthia K. Y.] Univ Hong Kong, Prince Philip Dent Hosp, Hong Kong, Hong Kong, Peoples
R China
[Ryou, Heonjune; Arola, Dwayne D.] Univ Maryland Baltimore Cty, Dept Mech Engn, Baltimore,
MD 21228 USA 通讯作者地址: Tay, FR (通讯作者),Georgia Hlth Sci Univ, Sch Grad Studies, Augusta, GA
30912 USA 电子邮件地址: [email protected]; [email protected]
出版商: ELSEVIER SCI LTD 出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,
OXON, ENGLAND
Web of Science 分类: Engineering, Biomedical; Materials Science, Biomaterials 学科类别: Engineering; Materials Science
IDS 号: 836LP
ISSN: 0142-9612
29 字符的来源出版物名称缩写: BIOMATERIALS
ISO 来源出版物缩写: Biomaterials 来源出版物页码计数: 10 基金资助致谢: 基金资助机构 授权号
NIDCR R21 DE019213
Georgia Health Sciences University
This work was supported by grant R21 DE019213 from NIDCR (Pl. Franklin Tay) and the PSRP
and ESA awards from the Georgia Health Sciences University. We thank R. Smith (Electron
Microscopy Core Unit, Georgia Health Sciences University, USA) for performing electron
diffractions, F. Chan (Electron Microscopy Unit, The University of Hong Kong, China) for
performing STEM-EDX and electron tomography and M. Burnside for secretarial support.
第 7 条,共 86 条 标题: Antioxidative and anti-inflammatory properties of Chushizi oil from Fructus Broussonetiae 作者: Zhao, HF (Zhao, Hongfang); Huang, LZ (Huang, Linzhang); Qin, LP (Qin, Luping); Huang,
BK (Huang, Baokang) 来源出版物 : JOURNAL OF MEDICINAL PLANTS RESEARCH 卷 : 5 期 : 28 页 :
6407-6412 DOI: 10.5897/JMPR11.447 出版年: NOV 30 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 19 摘要: The fruit of Broussonetia papyrifera (L.) L'Herit. ex Vent. is a traditional Chinese medicine
with Chinese name Chushizi. It has been commonly used as an important tonic for the treatment
of age-related disorders. In this work, the antioxidant properties of the oil were investigated on
nitric oxide production in lipopolysaccharide (LPS), activated RAW264.7 cells along with the
1,1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide anion and hydroxyl radical scavenging
assays. The chemical composition of the oil was analyzed by Gas chromatography-mass
spectrometry (GC-MS). The oil mainly consists of 8, 11-octadecadienic acid (79.17%). It
possessed DPPH/superoxide anion/hydroxyl free radical scavenging and NO production inhibition
activities (IC50 58.00 +/- 0.37 mu g/ml). The results indicated that Chushizi oil was a powerful
antioxidant with versatile free radical-scavenging activity, which may have therapeutic potential in
associated with various inflammatory diseases. 入藏号: WOS:000298913200003 语种: English 文献类型: Article 作者关键词: Chushizi; Broussonetia papyrifera; anti-inflammatory; antioxidant
KeyWords Plus: FREE-RADICALS; LONICERA-JAPONICA; PAPYRIFERA 地址: [Zhao, Hongfang; Huang, Linzhang; Qin, Luping; Huang, Baokang] Mil Med Coll 2, Sch
Pharm, Shanghai 200433, Peoples R China
[Zhao, Hongfang; Huang, Linzhang] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou
350108, Peoples R China 通讯作者地址: Huang, BK (通讯作者),Mil Med Coll 2, Sch Pharm, Shanghai 200433, Peoples R
China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
Web of Science 分类: Chemistry, Medicinal 学科类别: Pharmacology & Pharmacy
IDS 号: 873WE
ISSN: 1996-0875
29 字符的来源出版物名称缩写: J MED PLANTS RES
ISO 来源出版物缩写: J. Med. Plants Res. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China 30870236
The work was supported by the National Natural Science Foundation of China (No. 30870236).
We thank Yanjie Wei and Liming Xue for the experiment assistances.
第 8 条,共 86 条 标题: The genus Desmodium (Fabaceae)-traditional uses in Chinese medicine, phytochemistry
and pharmacology 作者: Ma, XQ (Ma, Xueqin); Zheng, CJ (Zheng, Chengjian); Hu, CL (Hu, Changling); Rahman,
K (Rahman, Khalid); Qin, LP (Qin, Luping) 来源出版物: JOURNAL OF ETHNOPHARMACOLOGY 卷: 138 期: 2 页: 314-332 DOI:
10.1016/j.jep.2011.09.053 出版年: NOV 18 2011 在 Web of Science 中的被引频次: 0
被引频次合计: 0 引用的参考文献数: 115 摘要: Ethnopharmacological relevance: Plants of the genus Desmodium (Fabaceae), such as
Desmodium styracifolium (Osbeck) Merr. and Desmodium gyrans (L f.) DC., have a long history
of medical use in Traditional Chinese Medicine to treat various ailments including rheumatism,
pyrexia, dysentery, wounds, cough, malaria, hepatitis, hemoptysis, etc. In the theory of Traditional
Chinese Medicine, most species have the effect of relieving internal heat or fever, neutralizing
toxins, inhibiting pain, invigorating blood circulation, suppressing cough and alleviating dyspnea.
Materials and methods: A bibliographic investigation was accomplished by analyzing secondary
sources including Chinese Herbal Classics, and worldwide accepted scientific databases (Pubmed.
Scopus and Web of Science, SciFinder) were scrutinized for the available information on the
ethnopharmacological uses in Chinese medicine, phytochemistry, pharmacology and toxicology of
Desmodium species.
Results: The genus Desmodium is a large member of the Papilionaceae (Fabaceae) family. It
contains about 350 plant species used for both feeding stuffs and herbal medicines, of which only
about 30 species have been phytochemically or pharmacologically investigated. Desmodium plant
extracts, as well as the active principles, have been experimentally studied for their
anti-inflammatory, cytotoxic, antidiabetic, antinephrolithic, antibacterial, and nootropic activities
in vitro or in vivo. And so far, a total of 212 compounds have been isolated from 15 Desmodium
species and characterized mainly as flavonoids and alkaloids, followed by terpenoids, steroids,
phenols, phenylpropanoids, glycosides and a number of volatile oils. The remaining unrevealed
species are recorded chiefly in Asia and Africa being used in empirical treatment for various
diseases.
Conclusions: Desmodium species have long been used in TCM to treat various ailments. Available
scientific references revealed that the traditional medical uses of some important Desmodium
species in TCM have been evaluated by modern pharmacological studies. As literature
demonstrated, flavonoids and alkaloids are perhaps responsible for most of the activities shown by
the plants of this genus. Further studies are still required to reveal the structure-activity
relationship of these active constituents. (C) 2011 Elsevier Ireland Ltd. All rights reserved. 入藏号: WOS:000298026400005 语种: English 文献类型: Review 作者关键词: Desmodium; Phytochemistry; Alkaloids; Flavonoids; Pharmacology; Toxicology
KeyWords Plus: PUSH-PULL TECHNOLOGY; AQUEOUS EXTRACT;
BETA-PHENETHYLAMINE; GANGETICUM EXTRACT; STRIGA-HERMONTHICA;
WESTERN KENYA; ROOT EXUDATE; ADSCENDENS; ISOFLAVANONES; UNCINATUM 地址: [Ma, Xueqin; Zheng, Chengjian; Hu, Changling; Qin, Luping] Mil Med Coll 2, Dept
Pharmacognosy, Sch Pharm, Shanghai 200433, Peoples R China
[Ma, Xueqin] NingXia Med Univ, Sch Pharm, Dept Pharmaceut Anal, Yinchuan 750004, Peoples
R China
[Hu, Changling] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108, Peoples R China
[Rahman, Khalid] Liverpool John Moores Univ, Fac Sci, Sch Biomol Sci, Liverpool L3 3AF,
Merseyside, England
通讯作者地址: Qin, LP (通讯作者),Mil Med Coll 2, Dept Pharmacognosy, Sch Pharm, 325
Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: ELSEVIER IRELAND LTD 出版商地址: ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO,
CLARE, 00000, IRELAND
Web of Science 分类: Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
Medicine; Pharmacology & Pharmacy 学科类别: Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine
IDS 号: 861NN
ISSN: 0378-8741
29 字符的来源出版物名称缩写: J ETHNOPHARMACOL
ISO 来源出版物缩写: J. Ethnopharmacol. 来源出版物页码计数: 19
第 9 条,共 86 条 标题: Anthraquinone compounds from Morinda officinalis inhibit osteoclastic bone resorption in
vitro 作者: Bao, LL (Bao, Leilei); Qin, LP (Qin, Luping); Liu, L (Liu, Lei); Wu, YB (Wu, Yanbin);
Han, T (Han, Ting); Xue, LM (Xue, Liming); Zhang, QY (Zhang, Qiaoyan) 来源出版物: CHEMICO-BIOLOGICAL INTERACTIONS 卷: 194 期: 2-3 页: 97-105 DOI:
10.1016/j.cbi.2011.08.013 出版年: NOV 15 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 31 摘要: The root of Morinda officinalis has been claimed to have a protective effect against bone
loss in sciatic neurectomized and ovariectomized osteoporotic rats, and this protective effect is
supposed to be attributed to anthraquinone compounds in the plant. In the present study, we
investigated the effects of three anthraquinones isolated from M. officinalis, including 1, 3,
8-trihydroxy-2-methoxy-anthraquinone (1), 2-hydroxy-1-methoxy-anthraquinone (2) and rubiadin
(3) on bone resorption activity in vitro and the mechanism on osteoclasts derived from rat bone
marrow cells. Compound 1, 2 and 3 decreased the formation of bone resorption pits, the number
of multinucleated osteoclasts, and the activity of tartrate resistant acid phosphates (TRAP) and
cathepsin K in the coculture system of osteoblasts and bone marrow cells in the presence of 1,
25-dihydroxyvitamine D(3) and dexamethasone. They also enhanced the apoptosis of osteoclasts
induced from bone marrow cells with M-CSF and RANKL In addition, Compound 1,2 and 3
improved the ratio of mRNA and protein expression of OPG and RANKL in osteoblasts,
interfered with the JNK and NF-kappa B signal pathway, and reduced the expression of calcitonin
receptor (CTR) and carbonic anhydrase/II (CA II) in osteoclasts induced from bone marrow cells
with M-CSF and RANKL These findings indicate that the anthraquinone compounds from M.
officinalis are potential inhibitors of bone resorption, and may also serve as evidence to explain
the mechanism of the inhibitory effects of some other reported anthraquinones on bone loss. (C)
2011 Elsevier Ireland Ltd. All rights reserved. 入藏号: WOS:000298459200002 语种: English 文献类型: Article 作者关键词: Morinda officinalis; Anthraquinone; Osteoclast; Bone resorption; Apoptosis
KeyWords Plus: GENE-EXPRESSION; KAPPA-B; RECEPTOR ACTIVATOR;
DIFFERENTIATION; RANKL; INDUCTION; APOPTOSIS; NFAT2 地址: [Bao, Leilei; Qin, Luping; Liu, Lei; Han, Ting; Xue, Liming; Zhang, Qiaoyan] Mil Med
Coll 2, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China
[Bao, Leilei] 411 Hosp PLA, Shanghai 200434, Peoples R China
[Liu, Lei; Wu, Yanbin] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108, Peoples R
China 通讯作者地址: Zhang, QY (通讯作者),Mil Med Coll 2, Sch Pharm, Dept Pharmacognosy, 325
Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected] 出版商: ELSEVIER IRELAND LTD 出版商地址: ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO,
CLARE, 00000, IRELAND
Web of Science 分类 : Biochemistry & Molecular Biology; Pharmacology & Pharmacy;
Toxicology 学科类别: Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
IDS 号: 867MT
ISSN: 0009-2797
29 字符的来源出版物名称缩写: CHEM-BIOL INTERACT
ISO 来源出版物缩写: Chem.-Biol. Interact. 来源出版物页码计数: 9 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China 90709023
This study was supported by the National Natural Science Foundation of China (NO. 90709023).
第 10 条,共 86 条 标 题 : DRUG-ASSOCIATED DIFFUSE ALVEOLAR HEMORRHAGE SYNDROMES:
REPORT OF TWO CASES AND 1ITERATURE REVIEW 作者: Xue, Q (Xue, Q.); Jiao, WK (Jiao, W-K); Wu, JH (Wu, J-H); Zhang, W (Zhang, W.); Fang,
GJ (Fang, G-J); Deng, XY (Deng, X-Y); Cheng, Y (Cheng, Y.)
来源出版物: RESPIROLOGY 卷: 16 特刊: SI 页: 323-323 增刊: 2 出版年: NOV 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 0 入藏号: WOS:000298547101386 语种: English 文献类型: Meeting Abstract 作者关键词: Hemorrhage; Diffuse; Pulmonary alveoli; Drug 地址: [Xue, Q.; Jiao, W-K; Wu, J-H; Zhang, W.; Fang, G-J; Deng, X-Y; Cheng, Y.] Fujian Med
Univ, Fujian Univ Chinese Med, Ningde Hosp, Dept Resp Dis,Teaching Hosp, Ningde, Peoples R
China 通讯作者地址: 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Web of Science 分类: Respiratory System 学科类别: Respiratory System
IDS 号: 868SZ
ISSN: 1323-7799
29 字符的来源出版物名称缩写: RESPIROLOGY
ISO 来源出版物缩写: Respirology 来源出版物页码计数: 1
第 11 条,共 86 条 标题 : A (HNMR)-H-1-Based Metabonomics Study of Postmenopausal Osteoporosis and
Intervention Effects of Er-Xian Decoction in Ovariectomized Rats 作者: Xue, LM (Xue, Liming); Wang, Y (Wang, Yin); Liu, L (Liu, Lei); Zhao, L (Zhao, Lu); Han,
T (Han, Ting); Zhang, QY (Zhang, Qiaoyan); Qin, LP (Qin, Luping) 来源出版物: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 卷: 12 期: 11 页:
7635-7651 DOI: 10.3390/ijms12117635 出版年: NOV 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 39 摘 要 : A metabonomics method using H-1 nuclear magnetic resonance spectroscopy
((HNMR)-H-1) was applied to obtain a systematic view of the development and progression of
postmenopausal osteoporosis. Using partial least squares discriminant analysis (PLS-DA), 26 and
34 characteristic resonances were found respectively in urine and plasma of ovariectomized rats
(Variable importance, VIP value >= 1.0), and the significant altered metabolites identified in the
plasma and urine were 10 and 9, respectively. Changes in these metabolites were related to the
pathways of lipid, energy and amino acid metabolism, some of which involved the oxidative
system. The described method was also used to analyze the therapeutic effects of Er-Xian
Decoction (EXD), a traditional Chinese medicine widely used in the clinical treatment of
osteoporosis in China. The results showed that EXD administration could provide satisfactory
effects on osteoporosis through partially regulating the perturbed pathways of lipid, energy and
amino acid metabolism and improving the anti-oxidative ability. 入藏号: WOS:000297696100025 语种: English 文献类型: Article 作者关键词: (HNMR)-H-1; metabonomics; ovariectomized rats; postmenopausal osteoporosis;
Er-Xian Decoction
KeyWords Plus: CHINESE HERBAL FORMULA; MENOPAUSAL SYMPTOMS;
LIPID-METABOLISM; BONE LOSS; IN-VITRO; ESTROGEN; TAURINE;
17-BETA-ESTRADIOL; PROGESTIN 地址: [Xue, Liming; Liu, Lei; Zhao, Lu; Han, Ting; Zhang, Qiaoyan; Qin, Luping] Mil Med Coll
2, Sch Pharm, Shanghai 200433, Peoples R China
[Wang, Yin] 455 Hosp CPLA, Dept Pharmaceut, Shanghai 200052, Peoples R China
[Liu, Lei; Zhao, Lu] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108, Peoples R
China 通讯作者地址: Zhang, QY (通讯作者),Mil Med Coll 2, Sch Pharm, 325 Guohe Rd, Shanghai
200433, Peoples R China 电 子 邮 件 地 址 : [email protected]; [email protected]; [email protected];
[email protected]; [email protected]; [email protected]; [email protected] 出版商: MDPI AG 出版商地址: POSTFACH, CH-4005 BASEL, SWITZERLAND
Web of Science 分类: Chemistry, Multidisciplinary 学科类别: Chemistry
IDS 号: 857DS
ISSN: 1661-6596
29 字符的来源出版物名称缩写: INT J MOL SCI
ISO 来源出版物缩写: Int. J. Mol. Sci. 来源出版物页码计数: 17 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China 81073115
81173191
Key Program for Basic Research of Shanghai 09JC1417600
The work was supported by the National Natural Science Foundation of China (81073115,
81173191) and the Key Program for Basic Research of Shanghai (09JC1417600).
第 12 条,共 86 条 标题 : Xiongshao Capsule ((sic)) Promotes Angiogenesis of HUVEC via Enhancing Cell
Proliferation and Up-regulating the Expression of bFGF and VEGF 作者: Lin, JM (Lin Jiu-mao); Zhao, JY (Zhao Jin-yan); Zhuang, QC (Zhuang Qun-chuan); Hong,
ZF (Hong Zhen-feng); Peng, J (Peng Jun) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 11 页 :
840-846 DOI: 10.1007/s11655-011-0895-8 出版年: NOV 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 22 摘要: Objective: To evaluate the angiogenic effect of the Xiongshao capsule ((sic)., XSC) in
human umbilical vein endothelial cells (HUVEC), and to investigate the possible molecular
mechanisms mediating its biological effect. Methods: Serum pharmacology was applied in this
study, in which different doses of XSC were administrated to rats orally and then XSC-containing
serum (XSC-S) was collected for the following in vitro experiments. The viability of HUVEC was
determined by the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay.
Cell density was observed via phase-contrast microscopy. Fluorescence-activated cell sorting
analysis with propidium iodide staining was performed to determine cell cycle phase. Cell
migration was determined by wound-healing method. Capillary tube formation by HUVEC was
examined using ECMatrix gel-based assay. Vascular endothelial growth factor (VEGF) and basic
fibroblast growth factor (bFGF) expression levels were measured by reverse transcription
polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbant assay (ELISA) analyses.
Results: XSC-S dose-dependently stimulated proliferation of HUVEC by promoting the cell cycle
G1 to S progression. In addition, XSC-S treatment dramatically increased the migration and
capillary tube formation of HUVEC in a dose-dependent manner. Moreover, XSC-S enhanced the
expression of VEGF and bFGF at both mRNA and protein levels. Conclusion: XSC can promote
several features of angiogenesis in endothelial cells through up-regulating the expression of bFGF
and VEGF, suggesting that XSC may be a potential novel therapeutic agent for the treatment of
ischemic heart diseases. 入藏号: WOS:000296614000006 语种: English 文献类型: Article 作者关键词: Xiongshao capsule; Chinese medicine; angiogenesis; serum pharmacology
KeyWords Plus: FIBROBLAST-GROWTH-FACTOR; MEDICINE 地址: [Lin Jiu-mao; Zhao Jin-yan; Zhuang Qun-chuan; Hong Zhen-feng; Peng Jun] Fujian Univ
Tradit Chinese Med, Fujian Acad Integrat Med, Fuzhou 350108, Peoples R China
[Peng Jun] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med Geriatr, Fuzhou
350108, Peoples R China 通讯作者地址: Peng, J (通讯作者),Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med,
Fuzhou 350108, Peoples R China
电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA
Web of Science 分类: Integrative & Complementary Medicine 学科类别: Integrative & Complementary Medicine
IDS 号: 842QL
ISSN: 1672-0415
29 字符的来源出版物名称缩写: CHIN J INTEGR MED
ISO 来源出版物缩写: Chin. J. Integr. Med. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构 授权号
CHEN Ke-ji Integrative Medicine CKJ 2008056
CKJ 2010019
Supported by the Developmental Fund of CHEN Ke-ji Integrative Medicine (No. CKJ 2008056
and CKJ 2010019)
第 13 条,共 86 条 标题: Echocardiographic Abnormalities in a Cohort of Chinese Patients with Systemic Lupus
Erythematosus-A Retrospective Analysis of Eighty-Five Cases 作者: Yu, XH (Yu, Xuan-Hua); Li, YN (Li, Yi-Nong) 来源出版物: JOURNAL OF CLINICAL ULTRASOUND 卷: 39 期: 9 页: 519-526 DOI:
10.1002/jcu.20863 出版年: NOV-DEC 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 26 摘要: Objective. To investigate echocardiographic abnormalities in a cohort of Chinese patients
with systemic lupus erythematosus (SLE).
Methods. Eighty-five SLE patients who were hospitalized at our institution from January 2008 to
June 2009 were included. Their clinical manifestations, electrocardiogram, chest x-ray, CT scan,
and echocardiographic data were analyzed in relation to age, disease duration, and SLE disease
activity index (SLEDAI).
Results. Echocardiography showed abnormalities in 53 patients (62.35%), involving valves in
56.5% (n = 48), pericardium in 25.9%, left and right ventricle enlargement in 17.65% and 1.18%,
respectively, and auricle in 10.59% and 1.18% of the patients, respectively. The left ventricle
showed decreased compliance in 10.29%, impaired relaxation in 14.12%, and abnormal wall
motion in 42.35% of the patients. Interventricular septum thickness, left ventricular posterior wall
thickness, and isovolumic relaxation time were positively correlated with age (r = 0.42, 0.33, and
0.39, respectively, p < 0.01 for all variables), and disease duration (r = 0.22, 0.21, and 0.32,
respectively; p < 0.05). Left atrial and ventricular size were correlated with age (r = 0.32 and 0.41,
p > 0.01) and SLEDAI (p < 0.05).
Conclusions. Cardiac, especially valvular abnormalities are common in SLE patients and increase
with age and disease duration and activity. Inclusion of echocardiography in the clinical evaluation
of SLE patients could help identify an important subset of patients with cardiac abnormalities. (C)
2011 Wiley Periodicals, Inc. J Clin Ultrasound 39:519-526, 2011; Published online in Wiley
Online Library (wileyonlinelibrary.com). DOI: 10.1002/jcu.20863 入藏号: WOS:000296607700005 语种: English 文献类型: Article 作者关键词: systemic lupus erythematosus; cardiac involvement; echocardiography; retrospective
analysis
KeyWords Plus: CARDIAC INVOLVEMENT; DISEASE-ACTIVITY; ASSOCIATION;
DYSFUNCTION; HEART; PREVALENCE; ANTIBODIES; MORTALITY 地址: [Li, Yi-Nong] Fuzhou Gen Hosp, Dept Rheumatol, Fuzhou 350025, Peoples R China
[Yu, Xuan-Hua] Fujian Univ Tradit Chinese Med, Peoples Hosp, Dept Rheumatol, Fuzhou
350004, Peoples R China 通讯作者地址: Li, YN (通讯作者),Fuzhou Gen Hosp, Dept Rheumatol, 156 XierHuan Bei,
Fuzhou 350025, Peoples R China 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Web of Science 分类: Acoustics; Radiology, Nuclear Medicine & Medical Imaging 学科类别: Acoustics; Radiology, Nuclear Medicine & Medical Imaging
IDS 号: 842OB
ISSN: 0091-2751
29 字符的来源出版物名称缩写: J CLIN ULTRASOUND
ISO 来源出版物缩写: J. Clin. Ultrasound 来源出版物页码计数: 8
第 14 条,共 86 条 标题: VEGF expression in mesenchymal stem cells promotes bone formation of tissue-engineered
bones 作者: Liu, BL (Liu, Boling); Li, XH (Li, Xihai); Liang, GQ (Liang, Guiqing); Liu, XX (Liu,
Xianxiang) 来源出版物 : MOLECULAR MEDICINE REPORTS 卷 : 4 期 : 6 页 : 1121-1126 DOI:
10.3892/mmr.2011.559 出版年: NOV-DEC 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 22
摘要: The purpose of this study was to investigate the in vivo vascularization and bone formation
activity of tissue-engineered bone constructed using bone marrow mesenchymal stem cells
(MSCs) transfected with vascular endothelial growth factor (VEGF). The expression of VEGF165
in rat bone marrow MSCs was confirmed using RT-PCR and immunohistochemistry. The MSCs
were cultured together with nano-hydroxyapatite/collagen (NHAC) to form tissue-engineered
bone. Untransfected MSCs were used as controls. The mice were sacrificed, and the bone
xenografts were analyzed using immunohistochemistry and quantified for the degree of
vascularization and new bone formation. Based on our results, expression of the VEGF165 gene
was detected using RT-PCR and immunohistochemistry following transfection and 4 weeks of
selection. The co-cultured NHAC- and VEGF-transfected MSCs had significantly higher alkaline
phosphatase (AP) activity compared to the controls (P<0.05). In the mice that received the
tissue-engineered bone xenografts, clumps of cartilage cells, irregular bone-like tissue and
microvessels were observed. The growth of these structures progressed with time. In the control
mice, however, only small amounts of bone-like and fibrotic tissue were observed. The differences
between the control and experimental groups were statistically significant (P<0.05). In conclusion,
VEGF165-transfected bone marrow MSCs promotes vascularization of tissue-engineered bone
and ectopic osteogenesis. 入藏号: WOS:000295389400013 语种: English 文献类型: Article 作者关键词 : vascular endothelial growth factor; bone marrow mesenchymal stem cells;
tissue-engineered bone; vascularization; ectopic osteogenesis
KeyWords Plus: ENDOTHELIAL GROWTH-FACTOR; GENE-THERAPY; IN-VITRO;
ANGIOGENESIS; DIFFERENTIATION; MATRIX; DELIVERY 地址: [Li, Xihai; Liu, Xianxiang] Fujian Univ Tradit Chinese Med, Acad Integrated Chinese &
Western Med, Fuzhou 350108, Fujian, Peoples R China
[Liu, Boling; Liang, Guiqing] Fuzhou Integrated Chinese & Western Med Hosp Fuji, Fuzhou
350007, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrated Chinese &
Western Med, 1 Huatuo Rd, Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE
Web of Science 分类: Oncology; Medicine, Research & Experimental 学科类别: Oncology; Research & Experimental Medicine
IDS 号: 826XR
ISSN: 1791-2997
29 字符的来源出版物名称缩写: MOL MED REP
ISO 来源出版物缩写: Mol. Med. Rep. 来源出版物页码计数: 6
基金资助致谢: 基金资助机构 授权号
Fujian Key Laboratory of Integrative Medicine on Geriatrics 2008J1004-16
Development Fund of Chen Keji Integrated Chinese and Western Medicine CKJ2008003
This study was supported by the Open Fund of Fujian Key Laboratory of Integrative Medicine on
Geriatrics (no. 2008J1004-16) and the Development Fund of Chen Keji Integrated Chinese and
Western Medicine (no. CKJ2008003). The authors thank Dr Xia Bai from the Jiangsu Province
Blood Research Institute for providing the hVEGF165 full-length cDNA expression vector
pcDNA3.1-hVEGF165 and Professor Qingling Feng from the Tsinghua University for providing
the NHAC material.
第 15 条,共 86 条 标题: Effect of Hedyotis Diffusa Willd extract on tumor angiogenesis 作者: Lin, JM (Lin, Jiumao); Wei, LH (Wei, Lihui); Xu, W (Xu, Wei); Hong, ZF (Hong,
Zhenfeng); Liu, XX (Liu, Xianxiang); Peng, J (Peng, Jun) 来源出版物 : MOLECULAR MEDICINE REPORTS 卷 : 4 期 : 6 页 : 1283-1288 DOI:
10.3892/mmr.2011.577 出版年: NOV-DEC 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 30 摘要 : Inhibition of tumor angiogenesis has become an attractive target of anticancer
chemotherapy. However, drug resistance and cytotoxicity against non-tumor associated
endothelial cells limit the long-term use and the therapeutic effectiveness of angiogenesis
inhibitors, thus increasing the necessity for the development of multi-target agents with minimal
side effects. Traditional Chinese medicine (TCM) formulas, which have relatively fewer side
effects and have been used clinically to treat various types of diseases, including cancer, for
thousands of years, are considered to be multicomponent and multi-target agents exerting their
therapeutic function in a more holistic way. Hedyotis Diffusa (EEHDW) has long been used as an
important component in several TCM formulas to treat various types of cancer. Although recently
we reported that EEHDW promotes cancer cell apoptosis via activation of the
mitochondrial-dependent pathway, the precise mechanism of its tunioricidalactivity still remains
to be clarified. In the present study, we investigated the angiogenic effects of the ethanol extract of
EEHDW. Cell cycle analysis was perfomed using flow cytometry. Cell viability was analyzed
using MTT assay. We found that EEHDW inhibited angiogenesis in vivo in chick embryo
chorioallantoic membrane (CAM). In addition, we observed that EEHDW dose- and
time-dependently inhibited the proliferation of human umbilical vein endothelial cells (HUVEC)
by blocking the cell cycle G1 to S progression. Moreover, EEHDW inhibited the migration and
tube formation of HUVECs. Furthermore, EEHDW treatment down-regulated the mRNA and
protein expression levels of VEGF-A in HT-29 human colon carcinoma cells and HUVECs. Our
findings suggest that inhibiting tumor angiogenesis is one of the mechanisms by which EEHDW is
involved in cancer therapy. 入藏号: WOS:000295389400039 语种: English 文献类型: Article 作者关键词: tumor angiogenesis; traditional Chinese medicine; multi-target agents; Hedyotis
Diffusa Willd
KeyWords Plus: ENDOTHELIAL GROWTH-FACTOR; THERAPEUTIC IMPLICATIONS;
FACTOR EXPRESSION; NATURAL-PRODUCTS; CANCER; METASTASIS; CARCINOMA;
VEGF; MECHANISMS; PROGNOSIS 地址: [Lin, Jiumao; Wei, Lihui; Hong, Zhenfeng; Peng, Jun] Fujian Univ Tradit Chinese Med,
Fujian Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China
[Xu, Wei] Fujian Univ Tradit Chinese Med, Dept Pharmacol, Fuzhou 350108, Fujian, Peoples R
China
[Liu, Xianxiang] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med Geriatr, Fuzhou
350108, Fujian, Peoples R China 通讯作者地址: Peng, J (通讯作者),Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med, 1
Huatuo Rd, Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE
Web of Science 分类: Oncology; Medicine, Research & Experimental 学科类别: Oncology; Research & Experimental Medicine
IDS 号: 826XR
ISSN: 1791-2997
29 字符的来源出版物名称缩写: MOL MED REP
ISO 来源出版物缩写: Mol. Med. Rep. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
Natural Science Foundation of Fujian Province of China 2010J01195
Research Foundation of Education Bureau of Fujian Province of China JA10162
Developmental Fund of Chen Keji Integrative Medicine CKJ 2010019
National Natural Science Foundation of China 81073097
This study was sponsored by the Natural Science Foundation of Fujian Province of China
(2010J01195), the Research Foundation of Education Bureau of Fujian Province of China
(JA10162), the Developmental Fund of Chen Keji Integrative Medicine (CKJ 2010019) and the
National Natural Science Foundation of China (81073097).
第 16 条,共 86 条 标题: Construction of lentiviral shRNA expression vector targeting phospholipase D2 (PLD2)
gene 作者: Lian, XF (Lian, Xue-Feng); Yu, CX (Yu, Chuan-Xing); He, XL (He, Xiao-Li); Lin, JJ (Lin,
Jun-Jin); Chen, YZ (Chen, Yi-Zhong); Zhu, L (Zhu, Ling) 来 源出 版物 : AFRICAN JOURNAL OF BIOTECHNOLOGY 卷 : 10 期 : 66 页 :
15044-15050 DOI: 10.5897/AJB11.137 出版年: OCT 26 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 14 摘要 : The aim of this research was to construct a lentiviral shRNA vectors targeting
phospholipase D2 (PLD2) gene, thus providing information for further study of the biological
functions of PLD2 and clinical treatments of leukemia. Specific siRNA targets with short hairpin
frame were designed using the siDESIGN software and synthesized according to cDNA sequence
of PLD2 (GenBank accession number: NM_002663). DNA oligo was cloned into lentiviral
expression vector, and then polymerase chain reaction (PCR) and sequencing analyses were
conducted to verify the constructs. The verified vectors were co-transfected into 293FT cells that
could produce lentiviral. shRNA lentiviruses from the selected constructs were propagated and
harvested with a virus packaging system, and the virus titers were determined by flow cytometry.
After the lentiviral packing with PLD2-shRNA2 transfecting 293FT cells, using fluorescence
microscope, we found the lentiviral interference vectors, which have GFP report genes expression
accompanied with the host genes in 293FT cells. The optimal interfering target was then selected,
while the titer of lentiviral packing PLD2-shRNA was 3.47 x 10(4) TU/ml and the virus was
successfully packaged. PCR and sequencing analyses revealed that lentiviral shRNA vectors of
three targeting PLD2 gene were successfully constructed. 入藏号: WOS:000298549800049 语种: English 文献类型: Article 作者关键词: RNA interference (RNAi); phospholipase D2 (PLD2); lentiviral vectors
KeyWords Plus: CELLS 地址: [Lian, Xue-Feng; He, Xiao-Li; Lin, Jun-Jin; Chen, Yi-Zhong; Zhu, Ling] Fujian Med Univ,
Dept Immunol, Fuzhou 350004, Fujian, Peoples R China
[Lian, Xue-Feng; He, Xiao-Li; Lin, Jun-Jin; Chen, Yi-Zhong; Zhu, Ling] Fujian Med Univ, Ctr
Neurosci, Fuzhou 350004, Fujian, Peoples R China
[Yu, Chuan-Xing] Internal Med Second Peoples Hosp Fujian Prov, Fuzhou 350003, Fujian,
Peoples R China 通讯作者地址: Zhu, L (通讯作者),Fujian Med Univ, Dept Immunol, Fuzhou 350004, Fujian,
Peoples R China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
Web of Science 分类: Biotechnology & Applied Microbiology 学科类别: Biotechnology & Applied Microbiology
IDS 号: 868TX
ISSN: 1684-5315
29 字符的来源出版物名称缩写: AFR J BIOTECHNOL
ISO 来源出版物缩写: Afr. J. Biotechnol. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构 授权号
Fujian Science and Technique Foundation 2009I0008
National Natural Science Foundation of Fujian 2010J01170
Fujian Medical University Professor Foundation JS06006
Project supported by Fujian Science and Technique Foundation, No 2009I0008; and supported by
National Natural Science Foundation of Fujian, No: 2010J01170; and supported by Fujian Medical
University Professor Foundation, No. JS06006.
第 17 条,共 86 条 标题: Molecular Research on a Hypotensive Herb Formula and PPAR alpha Activation 作者: Chen, MM (Chen, Mei-mei); Lai, XM (Lai, Xin-mei); Li, C (Li, Chi); Yang, XM (Yang,
Xue-mei) 来源出版物: LATIN AMERICAN JOURNAL OF PHARMACY 卷: 30 期: 8 页: 1608-1613 出版年: OCT 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 25 摘要 : Surflex-dock method was explored to study interactions between Qingxuanjiangya
decoction (QXJYD in abbreviation, a famous hypotensive herb formula from Traditional Chinese
Medicine prescription) and Peroxisome proliferators activated receptor-alpha (PPAR alpha) for
detecting its pharmacological effects as well as to screen out PPAR alpha agonists. First, 28
compounds with values of PPAR alpha EC(50) from reported were introduced as a test set to
evaluate the docking accuracy according to the good validation between experimental values and
surflex-dock scores (correlation coefficient R = 0.866, RMSD = 1.169 angstrom, similarity =
0.804). And then, 739 molecules from QXJYD were docked to PPAR alpha by the validated way.
The result showed 200 compounds from QXJYD had activity with PPAR alpha and discovered
that a flavones compound (moralbanone, extracted from folium mori) with an excellent docking
score might be considered as a guide to design a new scaffold of PPAR alpha agonists in the
further study. 入藏号: WOS:000298869100024
语种: English 文献类型: Article 作者关键词: PPAR alpha Agonists; Qingxuanjiangya decoction; Surflex-dock
KeyWords Plus: RECEPTOR-ALPHA; PEROXISOME PROLIFERATORS;
PROTEIN-BINDING; ACID; IDENTIFICATION; STIMULATION; FLAVONO IDS;
DISCOVERY; AGONISTS; DOCKING 地址: [Chen, Mei-mei; Lai, Xin-mei; Yang, Xue-mei] Fujian Univ Tradit Chinese Med, Coll
Tradit Chinese Med, Fuzhou 350108, Fujian, Peoples R China
[Li, Chi] Tsinghua Univ, Dept Elect Engn, Beijing 100084, Peoples R China 通讯作者地址: Yang, XM (通讯作者),Fujian Univ Tradit Chinese Med, Coll Tradit Chinese Med,
Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES 出版商地址: DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
Web of Science 分类: Pharmacology & Pharmacy 学科类别: Pharmacology & Pharmacy
IDS 号: 873GM
ISSN: 0326-2383
29 字符的来源出版物名称缩写: LAT AM J PHARM
ISO 来源出版物缩写: Lat. Am. J. Pharm. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
Foundation of Science & Technology Project of Fujian 2009Y0030
2009J05074
Fujian Provincial Health Department
YA-204
wzzsj0901
wz-zsj0902
Fujian Provincial Department of Education JA09130
The authors thanks American Tripos Company for offering us Sybylx1.1 program. This work is
supported in part by Foundation of Science & Technology Project of Fujian (2009Y0030 and
2009J05074), by Fujian Provincial Health Department Special Project (YA-204 and wzzsj0901
and wz-zsj0902), by Fujian Provincial Department of Education project (JA09130).
第 18 条,共 86 条 标题: Solid-phase extraction-field-amplified sample injection coupled with CE-ESI-MS for online
pre-concentration and quantitative analysis of brain-gut peptides
作者: Ye, HZ (Ye, Hongzhi); Xia, SF (Xia, Shifei); Yu, LS (Yu, Lishuang); Xu, XQ (Xu, Xueqin);
Zheng, CS (Zheng, Chunsong); Xu, HF (Xu, Huifeng); Wang, LL (Wang, Lili); Liu, XX (Liu,
Xianxiang); Cai, ZW (Cai, Zongwei); Chen, GN (Chen, Guonan) 来源出版物 : ELECTROPHORESIS 卷 : 32 期 : 20 特刊 : SI 页 : 2823-2829 DOI:
10.1002/elps.201000591 出版年: OCT 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 44 摘要: In order to improve the sensitivity of CE-ESI-MS for the analysis of brain-gut peptides, a
solid-phase extraction combined with field-amplified sample injection was used for the
pre-concentration of the brain-gut peptides. Compared with the conventional pressure injection
method, the sensitivity in the detection of brain-gut peptides was improved more than 100-fold.
The possible factors affecting sample stacking, such as the sample matrix, the composition and the
length of the water column, the types and the volumes of eluent, have been investigated in detail.
Under the optimum conditions, the detectable concentration of brain-gut peptides was found to be
as low as 0.02 mu M. A linear response concentration for the detection was developed in the range
of 0.08-25 mu mol/L. A real sample of human cerebrospinal fluids, which was spiked with
brain-gut peptides, was also examined in order to evaluate the reliability of the proposed approach.
The recovery of the method was in a range from 69.2 to 85.4%. The method was found to be
reliable, accurate and potentially applicable for clinical drug analysis. 入藏号: WOS:000297424500008 语种: English 文献类型: Article 作者关键词: Brain-gut peptide; CE-ESI-MS; Cerebrospinal fluid; Field amplified; SPE
KeyWords Plus: ELECTROPHORESIS-MASS-SPECTROMETRY; PERFORMANCE
CAPILLARY-ELECTROPHORESIS; ELECTROSPRAY-IONIZATION;
ZONE-ELECTROPHORESIS; SENSITIVITY; STACKING; PROTEINS; OPTIMIZATION;
FLUORESCENCE; STRATEGIES 地址: [Ye, Hongzhi; Yu, Lishuang; Zheng, Chunsong; Wang, Lili; Liu, Xianxiang] Fujian Univ
Tradit Chinese Med, Acad Integrat Med, Fuzhou, Fujian, Peoples R China
[Xia, Shifei; Yu, Lishuang; Xu, Xueqin; Wang, Lili; Chen, Guonan] Fuzhou Univ, Minist Educ,
Fujian Prov Key Lab Anal & Detect Technol Food Sa, Key Lab Anal & Detect Food Safety,
Fuzhou 350002, Peoples R China
[Xia, Shifei; Yu, Lishuang; Xu, Xueqin; Wang, Lili; Chen, Guonan] Fuzhou Univ, Dept Chem,
Fuzhou 350002, Peoples R China
[Xu, Huifeng] Fujian Univ TCM, Fujian Key Lab Integrat Med Geriatr, Fuzhou, Peoples R China
[Cai, Zongwei] Hong Kong Baptist Univ, Dept Chem, Hong Kong, Hong Kong, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med,
Fuzhou, Fujian, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: WILEY-BLACKWELL
出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Web of Science 分类: Biochemical Research Methods; Chemistry, Analytical 学科类别: Biochemistry & Molecular Biology; Chemistry
IDS 号: 853KJ
ISSN: 0173-0835
29 字符的来源出版物名称缩写: ELECTROPHORESIS
ISO 来源出版物缩写: Electrophoresis 来源出版物页码计数: 7 基金资助致谢: 基金资助机构 授权号
NSFC 20928005
Key Natural Sciences Foundation of Fujian Province, China
D0520001
2010Y0032
2009J01172
Fujian Province Key Foundation of Chinese Medicine wzzg0901
Key Foundation of Education Department of Fujian Province, China JK2009016
This project was financially supported by NSFC (20928005), the Key Natural Sciences Foundation
of Fujian Province, China (D0520001, 2010Y0032, 2009J01172), Fujian Province Key Foundation
of Chinese Medicine (wzzg0901), the Key Foundation of Education Department of Fujian
Province, China (JK2009016).
第 19 条,共 86 条 标题 : Effect of Silver Colloid Concentration on Electroporation for Intracellular Surface
Enhanced Raman Scattering 作者: Yu, Y (Yu Yun); Lin, JQ (Lin Ju-Qiang); Huang, H (Huang Hao); Chen, YP (Chen
Yan-Ping); Feng, SY (Feng Shang-Yuan); Su, Y (Su Ying); Chen, JS (Chen Jie-Si); Chen, R (Chen
Rong) 来源出版物 : PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 卷 : 38 期 : 10 页 :
961-966 DOI: 10.3724/SP.J.1206.2011.00106 出版年: OCT 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 20 摘要: The effect of silver colloid concentration was explored for fastest delivery of silver
nanoparticles into living C666 cells (a human nasopharyngeal carcinoma cell line) for intracellular
surface enhanced raman scattering (SERS) by Electroporation. SERS spectra, the integrated SERS
intensity and the reproducibility of spectrum were compared in 6 electroporation experiments of
the same electric pulse parameters but different concentration of silver colloid. The silver
nanoparticle concentration is best under the condition of 500 mu l electroporation buffer
containing 50 mu l silver colloid using 875 V/cm, 1 ms rectangular electric pulses for
electroporation twice. Increasing the concentration of silver nanoparticle could improve the SERS
intensity while decrease the reproducibility of the spectrum. Moreover, the observed SERS bands
of living C666 cell were tentatively assigned. This work is promising for the practical application
of SERS technology, such as real time detection and analysis of the biochemical substance in
living cells. 入藏号: WOS:000296226100011 语种: Chinese 文献类型: Article 作者关键词: surface enhanced Raman scattering(SERS); electroporation; C666 cell; silver colloid
concentration
KeyWords Plus: LIVE CELLS; SPECTROSCOPY; NANOPARTICLES; TISSUES 地址: [Yu Yun; Lin Ju-Qiang; Feng Shang-Yuan; Chen Jie-Si; Chen Rong] Fujian Normal Univ,
Key Lab OptoElect Sci & Technol Med, Minist Educ, Fujian Prov Key Lab Photon Technol,
Fuzhou 350007, Peoples R China
[Yu Yun; Huang Hao] Fujian Univ Tradit Chinese Med, Dept Integrat Med, Fuzhou 350108,
Peoples R China
[Chen Yan-Ping; Su Ying] Fujian Prov Tumor Hosp, Fuzhou 350001, Peoples R China 通讯作者地址: Chen, R (通讯作者),Fujian Normal Univ, Key Lab OptoElect Sci & Technol
Med, Minist Educ, Fujian Prov Key Lab Photon Technol, Fuzhou 350007, Peoples R China 电子邮件地址: [email protected] 出版商: CHINESE ACAD SCIENCES, INST BIOPHYSICS 出版商地址: 15 DATUN RD, CHAOYAND DISTRICT, BEIJING, 100101, PEOPLES R CHINA
Web of Science 分类: Biochemistry & Molecular Biology; Biophysics 学科类别: Biochemistry & Molecular Biology; Biophysics
IDS 号: 837TM
ISSN: 1000-3282
29 字符的来源出版物名称缩写: PROG BIOCHEM BIOPHYS
ISO 来源出版物缩写: Prog. Biochem. Biophys. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China 60778046
60910106016
Science and Technology Project of Fujian Province 2008J0016
Science Foundation of Ministry of Health and United Fujian Provincial WKJ2008-2-046
This work was supported by grants from The National Natural Science Foundation of China
(60778046, 60910106016), The Science and Technology Project of Fujian Province (2008J0016,
2009J01276), and The Project of Science Foundation of Ministry of Health and United Fujian
Provincial Health and Education Project for Tackling the Key Research (WKJ2008-2-046).
第 20 条,共 86 条 标题: CacyBP/SIP Protein Promotes Proliferation and G1/S Transition of Human Pancreatic
Cancer Cells 作者: Chen, X (Chen, Xiong); Mo, P (Mo, Ping); Li, XH (Li, Xiaohua); Zheng, PC (Zheng,
Peichan); Zhao, LN (Zhao, Lina); Xue, ZF (Xue, Zengfu); Ren, G (Ren, Gui); Han, GH (Han,
Guohong); Wang, X (Wang, Xin); Fan, DM (Fan, Daiming) 来源出版物 : MOLECULAR CARCINOGENESIS 卷 : 50 期 : 10 页 : 804-811 DOI:
10.1002/mc.20737 出版年: OCT 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 29 摘要: Calcyclin-binding protein or Siah-1-interacting protein (CacyBP/SIP), a component of the
ubiquitin-mediated proteolysis, could participate in beta-catenin degradation, which was found to
be related to the malignant phenotypes of pancreatic cancer previously. However, the role of
CacyBP/SIP itself in pancreatic cancer has not been investigated. In the present study, CacyBP/SIP
expression was assayed and manipulated to reveal the potential mechanism in pancreatic cancer
carcinogenesis. Here, we show that CacyBP/SIP is over-expressed in pancreatic cancer cells.
Down-regulation of CacyBP/SIP by small interference RNA (siRNA) severely suppresses the
proliferation and tumorigenesis in pancreatic cancer. G1/S transition arrest induced by inhibition
of CacyBP/SIP is at least partly mediated by down-regulation of Cyclin E and CDK2 as well as
up-regulation of p27 and Rb. Collectively, CacyBP/SIP as an enhancer of pancreatic cancer
malignance might develop into another possible therapeutic target. (C) 2011 Wiley-Liss, Inc. 入藏号: WOS:000294883800007 语种: English 文献类型: Article 作者关键词: CacyBP/SIP; proliferation; cell cycle; pancreatic cancer
KeyWords Plus: BINDING-PROTEIN; SIGNALING PATHWAY; CALCYCLIN; EXPRESSION;
PROSTATE; APOPTOSIS; RECEPTOR; DIFFERENTIATION; TARGET; GROWTH 地址: [Chen, Xiong; Mo, Ping; Li, Xiaohua; Zhao, Lina; Xue, Zengfu; Ren, Gui; Han, Guohong;
Wang, Xin; Fan, Daiming] Fourth Mil Med Univ, State Key Lab Canc Biol, Xian 710032,
Shaanxi, Peoples R China
[Chen, Xiong; Mo, Ping; Li, Xiaohua; Zhao, Lina; Xue, Zengfu; Ren, Gui; Han, Guohong; Wang,
Xin; Fan, Daiming] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian 710032, Shaanxi,
Peoples R China
[Zheng, Peichan] Peoples Hosp Fujian Prov, Dept Clin Lab, Fuzhou, Fujian, Peoples R China 通讯作者地址: Wang, X (通讯作者),Fourth Mil Med Univ, Key Lab Canc Biol, 17 Changle
Western Rd, Xian 710032, Shaanxi, Peoples R China 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Web of Science 分类: Biochemistry & Molecular Biology; Oncology 学科类别: Biochemistry & Molecular Biology; Oncology
IDS 号: 820CT
ISSN: 0899-1987
29 字符的来源出版物名称缩写: MOL CARCINOGEN
ISO 来源出版物缩写: Mol. Carcinog. 来源出版物页码计数: 8 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China 30871143
National Basic Research Program of China 2010CB529300
2010CB529306
We thank Taidong Qiao and Zheng Chen for excellent experimental assistant and Yongzhan Nie
for constructive advice. This study was supported by the National Natural Science Foundation of
China (No. 30871143) and the National Basic Research Program of China (No.2010CB529300
and No.2010CB529306).
第 21 条,共 86 条 标题: Effects of Herba Epimedii and Fructus Ligustri lucidi on the Transcription Factors in
Hypothalamus of Aged Rats 作者: Cai, J (Cai Jing); Zheng, T (Zheng Teng); Zhang, L (Zhang Lei); Tian, Y (Tian Yun); Yang,
MH (Yang Min-he); Du, J (Du Jian) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 10 页 :
758-763 DOI: 10.1007/s11655-011-0636-z 出版年: OCT 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 19 摘要: Objective: To comparatively analyze the difference in the expression of 54 transcription
factors in the hypothalamus using protein chips following the medication of Chinese drugs for
Shen ((sic))-tonification, Herba Epimedii, and Fructus Ligustri lucidi (FL) to aged rats. Methods:
Wistar rats, aged 15 months of SPF grade, were randomized into three groups, three males and
three females in each group. They were medicated with Herba Epimedii decoction (HED, 0.14
g/kg), Fructus Ligustri lucidi decoction (FLD, 0.12 g/kg), and distilled water, respectively, twice a
day for 15 days. The rats were sacrificed at the morning of the 16th day 1 h after medication, and
their hypothalamus was taken and made into homogenate under an ice-bath for detecting the
expression of transcription factors with chip technique. Results: The expressions of signal
transduction and transcription activation factor-6 (Stat-6) and androgen receptor (AR) were
up-regulated, and those of pre-B transcription factor1 (Pbx-1), stat-1 and AP-2 were
down-regulated in both HED and FLD treated groups, but these changes occurred mainly in
female rats in the former while mainly in males in the latter. Conclusions: Chinese drugs for
Shen-tonification could impact the expression of transcription factors in the hypothalamus of aged
rats, dominantly on the neuro-endocrine factors responsible for the growth and development. The
effects of drugs for tonifying Shen-yang and for tonifying Shen-yin are different, which is
probably one of the pharmacological mechanisms of the Shen-tonifying drugs. 入藏号: WOS:000295548600007 语种: English 文献类型: Article 作者关键词: Herba Epimedii; Fructus Ligustri lucidi; transcription factor; aged rat; hypothalamus
KeyWords Plus: EXPRESSION; PBX1; CELLS 地址: [Cai Jing; Tian Yun; Du Jian] Fujian Univ Tradit Chinese Med, Fujian Inst Integrat Chinese
& Western Med, Fuzhou 350108, Peoples R China
[Zhang Lei; Yang Min-he] Fujian Normal Univ, Fuzhou 350108, Peoples R China
[Zheng Teng] Fujian Entry Exit Inspect & Quarantine Bur PR Chi, Fuzhou 350001, Peoples R
China 通讯作者地址: Cai, J (通讯作者),Fujian Univ Tradit Chinese Med, Fujian Inst Integrat Chinese
& Western Med, Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA
Web of Science 分类: Integrative & Complementary Medicine 学科类别: Integrative & Complementary Medicine
IDS 号: 829BC
ISSN: 1672-0415
29 字符的来源出版物名称缩写: CHIN J INTEGR MED
ISO 来源出版物缩写: Chin. J. Integr. Med. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China 30672729
CHEN Ke-ji Development Fund of Integrative Medicine CKJ2010025
Supported by the National Natural Science Foundation of China (No. 30672729), CHEN Ke-ji
Development Fund of Integrative Medicine (No. CKJ2010025)
第 22 条,共 86 条 标题: Relationship of carotid intima-media thickness and duration of vegetarian diet in Chinese
male vegetarians 作者: Yang, SY (Yang, Shu-Yu); Zhang, HJ (Zhang, Hui-Jie); Sun, SY (Sun, Su-Yun); Wang, LY
(Wang, Li-Ying); Yan, B (Yan, Bing); Liu, CQ (Liu, Chang-Qin); Zhang, W (Zhang, Wei); Li, XJ
(Li, Xue-Jun) 来 源 出 版 物 : NUTRITION & METABOLISM 卷 : 8 文 献 号 : 63 DOI:
10.1186/1743-7075-8-63 出版年: SEP 19 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 34 摘要: Objective: Many studies have shown that vegetarian diet has beneficial effects on the
prevention of cardiovascular diseases. However, the effect of vegetarian diet on carotid
intima-media thickness (IMT), as well as the association between IMT and duration of vegetarian
diet, are still unclear. The present study aims to investigate the influence of duration of vegetarian
diet on cardiovascular risk factors, and more importantly on IMT among Chinese vegetarians.
Methods: One hundred and seventy-one Chinese male vegetarians were screened for metabolic
profile, cardiovascular risk and carotid IMT. They were compared with 129 age-matched
omnivores recruited from a community-based health project. The effects of confounding factors
were adjusted by stepwise logistic regression analysis.
Results: Compared to the omnivores, the vegetarians had lower BMI, weight, systolic blood
pressure and diastolic blood pressure. Also, the levels of triglyceride, total cholesterol,
HDL-Cholesterol, LDL-Cholesterol, ApoA1, ApoB, uric acid, albumin and g-glutamyltransferase
were significantly reduced in vegetarians. Omnivores had significantly higher fasting blood
glucose than that of vegetarians. However, there were no differences in fasting insulin, C-reactive
protein and HOMA-IR between the two groups. IMT was thinner in the vegetarian group than in
the omnivore group (0.59 +/- 0.16 vs. 0.63 +/- 0.10 cm, P < 0.05). The vegetarians were divided
according to duration of vegetarian diet (< 6 years, 6 to <= 11 years, > 11 years), those in tertile 1
(< 6 years) and tertile 2 (6 to <= 11 years) had shown thinner IMT as compared to the omnivores,
and tertile 3 had shown no reduction.
Conclusion: A decrease in multiple cardiovascular risk factors such as BMI, blood pressure and
lipid profile was associated with vegetarian diet. Moreover, taking a low-calorie, low-protein, or
vegetarian diet might have great beneficial effects on IMT through improved lipid profile, and the
beneficial effects appeared to be correlated with the duration of vegetarian diet. 入藏号: WOS:000295594900001 语种: English 文献类型: Article 作者关键词: vegetarian diet; IMT; duration of vegetarian diet
KeyWords Plus: CARDIOVASCULAR RISK PROFILE; C-REACTIVE PROTEIN;
NUTRITION TRANSITION; METABOLIC SYNDROME; MORTALITY; DISEASE;
MARKERS; ATHEROSCLEROSIS; INFLAMMATION; OMNIVORES 地址: [Yang, Shu-Yu] Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med, Fuzhou
350108, Peoples R China
[Yang, Shu-Yu; Zhang, Hui-Jie; Sun, Su-Yun; Wang, Li-Ying; Yan, Bing; Liu, Chang-Qin; Zhang,
Wei; Li, Xue-Jun] Xiamen Univ, Affiliated Hosp 1, Dept Diabet, Xiamen Diabet Inst, Xiamen
361003, Peoples R China 通讯作者地址: Yang, SY (通讯作者),Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med,
1 Hua Tuo Rd, Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: BIOMED CENTRAL LTD 出版商地址: 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
Web of Science 分类: Nutrition & Dietetics 学科类别: Nutrition & Dietetics
IDS 号: 829PA
ISSN: 1743-7075
29 字符的来源出版物名称缩写: NUTR METAB
ISO 来源出版物缩写: Nutr. Metab. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构 授权号
Natural Science Foundation of China 81000320
Natural Science Foundation of Fujian Province and Xiamen 2009D016
3502Z20104026
Youth Foundation of Fujian Provincial Health Department 2010-2-86
We are grateful to the consideration and cooperation of all the participants of the study. The
authors would like to acknowledge Prof. Xiao-Ying Li from Rui-jin Hospital Affiliated to
Shanghai Jiaotong University, for his advices in the present project. This study is supported by the
grants from the Natural Science Foundation of China (NO. 81000320), the Natural Science
Foundation of Fujian Province and Xiamen (NO. 2009D016 and 3502Z20104026) and the Youth
Foundation of Fujian Provincial Health Department (NO.2010-2-86).
第 23 条,共 86 条 标题: Synthesis and photobiological study of a novel chlorin photosensitizer BCPD-18MA for
photodynamic therapy 作者: Zhang, JL (Zhang, Jialiang); Deng, L (Deng, Li); Yao, JZ (Yao, Jianzhong); Gu, P (Gu,
Peng); Yang, F (Yang, Feng); Wang, XX (Wang, Xiuxin); Liu, W (Liu, Wei); Zhang, YY (Zhang,
Yingying); Ke, XF (Ke, Xingfa); Jing, XL (Jing, Xiaolong); Chen, JM (Chen, Jianming) 来 源 出 版 物 : BIOORGANIC & MEDICINAL CHEMISTRY 卷 : 19 期 : 18 页 :
5520-5528 DOI: 10.1016/j.bmc.2011.07.041 出版年: SEP 15 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 35 摘要 : This paper reports synthesis and photobiological properties of a novel chlorin
photosensitizer BCPD-18MA. Cytotoxicity, cellular uptake, subcellular location, biodistribution,
photodynamic therapy (PDT) efficiency, cell apoptosis as well as histological analysis of the
liposomal-delivered BCPD-18MA (L-BCPD-18MA) was studied using mammary
adenocarcinoma MDA-MB-231 cells and Lewis lung carcinoma (LLC) implanted in C57BL/6
mice as experimental models. The results showed that L-BCPD-18 was incorporated rapidly into
MDA-MB-231 cells and localized partially in mitochondria. L-BCPD-18 induced cell apoptosis
by PDT. In addition, biodistribution of L-BCPD-18MA in LLC-bearing mice demonstrated a fast
clearance rate of the drug and good skin-related tumor selectivity. Finally, entrapment of
BCPD-18 into liposomes resulted in a dramatic impairment of dark toxicity and a notable
improvement of PDT antitumor efficacy in vitro. Compared with liposomal-delivered BPDMA
(L-BPDMA), L-BCPD-18MA exhibited low dark toxicity and high PDT efficiency on
MDA-MB-231 cells. The photodynamic efficacy of L-BCPD-18MA on LLC-bearing mice is
comparable to that of L-BPDMA, implying that L-BCPD-18MA is a potential antitumor candidate
for PDT. (C) 2011 Elsevier Ltd. All rights reserved. 入藏号: WOS:000294711100024 语种: English 文献类型: Article 作者关键词: Cancer; Photodynamic therapy; Liposome; Chlorin; Photosensitizer; Apoptosis;
Synthesis
KeyWords Plus: BASIC PRINCIPLES; MECHANISMS; APOPTOSIS; TUMORS; DIFFUSION;
INDUCTION; LIPOSOMES; DELIVERY; CELLS 地址: [Zhang, Jialiang; Deng, Li; Yao, Jianzhong; Gu, Peng; Yang, Feng; Wang, Xiuxin; Liu, Wei;
Zhang, Yingying; Ke, Xingfa; Jing, Xiaolong; Chen, Jianming] Mil Med Coll 2, Sch Pharm,
Shanghai 200433, Peoples R China
[Zhang, Jialiang; Ke, Xingfa; Jing, Xiaolong] Fujian Univ Tradit Chinese Med, Dept Pharm,
Fujian 350108, Peoples R China 通讯作者地址: Chen, JM (通讯作者),Mil Med Coll 2, Sch Pharm, Shanghai 200433, Peoples R
China 电子邮件地址: [email protected]; [email protected] 出版商: PERGAMON-ELSEVIER SCIENCE LTD 出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,
ENGLAND
Web of Science 分类: Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
Organic
学科类别: Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
IDS 号: 817XO
ISSN: 0968-0896
29 字符的来源出版物名称缩写: BIOORGAN MED CHEM
ISO 来源出版物缩写: Bioorg. Med. Chem. 来源出版物页码计数: 9 基金资助致谢: 基金资助机构 授权号
Nation Natural Science Foundation of China 30371737
Foundation of China 2009ZXJ09003-028
This research was supported by the Nation Natural Science Foundation of China (Grant No.
30371737) and the National Science & Technology Major Project 'Major New Drug Creation
Program' Foundation of China (Grant No. 2009ZXJ09003-028).
第 24 条,共 86 条 标题 : Synthesis and Biological Activities of Novel Danshensu Amide Derivatives as
Anti-Myocardial Ischemia Agents 作者: Wang, TF (Wang, Tingfang); Shu, JJ (Shu, Jingjing); Zheng, LP (Zheng, Liping); Xiong, LY
(Xiong, Liyan); Wang, J (Wang, Jing); Jin, L (Jin, Lei); Wu, QY (Wu, Qiuye); Zou, H (Zou, Hao);
Zhang, C (Zhang, Chuan) 来源出版物: LATIN AMERICAN JOURNAL OF PHARMACY 卷: 30 期: 7 页: 1355-1359 出版年: SEP 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 21 摘要: A series of novel danshensu amide derivatives were synthesized, and the protective effects
of all the compounds on rat myocardial cell lines H9C2 by hypoxia were investigated. The results
showed that all the seven compounds could significantly increased cell viability compared with
hypoxia group. Among these compounds,
3-(3,4-dimethoxyphenyl)-2-hydroxy-N-propylpropanamide (6) exhibited good activities, with cell
viability reached 94.2 % compared to the normal. The novel danshensu amide derivatives,
possessing an additional lipophilic alkyl chain showed a good lipophilicity. 入藏号: WOS:000298220700016 语种: English 文献类型: Article 作者关键词: Anti-myocardial ischemia activities; Danshensu amide derivatives; Lipophilicity;
Synthesis
KeyWords Plus: SALVIA-MILTIORRHIZA; AQUEOUS EXTRACT; DYSFUNCTION;
ARTERY 地址: [Wang, Tingfang; Shu, Jingjing; Zheng, Liping; Xiong, Liyan; Wang, Jing; Jin, Lei; Zou,
Hao; Zhang, Chuan] Mil Med Coll 2, New Drug Res Ctr, Sch Pharm, Shanghai 200433, Peoples R
China
[Wang, Tingfang; Shu, Jingjing; Zheng, Liping] Fujian Univ Tradit Chinese Med, Sch Pharm,
Fuzhou 350108, Fujian, Peoples R China
[Wu, Qiuye] Mil Med Coll 2, Dept Organ Chem, Sch Pharm, Shanghai 200433, Peoples R China 通讯作者地址: Zou, H (通讯作者),Mil Med Coll 2, New Drug Res Ctr, Sch Pharm, Guohe Rd
325, Shanghai 200433, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES 出版商地址: DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
Web of Science 分类: Pharmacology & Pharmacy 学科类别: Pharmacology & Pharmacy
IDS 号: 864EV
ISSN: 0326-2383
29 字符的来源出版物名称缩写: LAT AM J PHARM
ISO 来源出版物缩写: Lat. Am. J. Pharm. 来源出版物页码计数: 5 基金资助致谢: 基金资助机构 授权号
Science and Technology Commission of Shanghai 08DZ1970802
National Basic Research Program of China 2006CB504100
2009CB521907
This study was supported by the Science and Technology Commission of Shanghai special
purpose for modernization of traditional Chinese medicine in 2008 (No. 08DZ1970802) and
National Basic Research Program of China (No. 2006CB504100 and 2009CB521907).
第 25 条,共 86 条 标题: Scientific research at Fujian Academy of Integrative Medicine: Current status and future
directions 作者: Liu, XX (Liu Xian-xiang); Wu, JZ (Wu Jin-zhong); Lin, YP (Lin Yan-ping); Cao, ZY (Cao
Zhi-yun); Peng, J (Peng Jun); Cai, J (Cai Jing); Tan, CJ (Tan Chun-jiang); Liao, LM (Liao
Lian-ming); Du, J (Du Jian) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 9 页 :
643-649 DOI: 10.1007/s11655-011-0840-x 出版年: SEP 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0
引用的参考文献数: 88 入藏号: WOS:000294820500001 语种: English 文献类型: Editorial Material
KeyWords Plus: MESENCHYMAL STEM-CELLS; TOUGU XIAOTONG GRANULE; KNEE
OSTEOARTHRITIS; COMPUTATIONAL PHARMACOLOGY;
CAPILLARY-ELECTROPHORESIS; INDUCED DIFFERENTIATION; APOPTOSIS;
PATHWAY; PROLIFERATION; CHONDROCYTES 地址: [Liu Xian-xiang; Wu Jin-zhong; Lin Yan-ping; Cao Zhi-yun; Peng Jun; Cai Jing; Tan
Chun-jiang; Liao Lian-ming; Du Jian] Fujian Acad Integrat Med, Fuzhou 350108, Peoples R
China 通讯作者地址: Du, J (通讯作者),Fujian Acad Integrat Med, Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA
Web of Science 分类: Integrative & Complementary Medicine 学科类别: Integrative & Complementary Medicine
IDS 号: 819JF
ISSN: 1672-0415
29 字符的来源出版物名称缩写: CHIN J INTEGR MED
ISO 来源出版物缩写: Chin. J. Integr. Med. 来源出版物页码计数: 7
第 26 条,共 86 条 标题: Pien Tze Huang (c parts per thousand double dagger a >>"c (TM) Euro)-induced apoptosis
in human colon cancer HT-29 cells is associated with regulation of the Bcl-2 family and activation
of caspase 3 作者: Lin, JM (Lin Jiu-mao); Wei, LH (Wei Li-hui); Chen, YQ (Chen You-qin); Liu, XX (Liu
Xian-xiang); Hong, ZF (Hong Zhen-feng); Sferra, TJ (Sferra, Thomas J.); Peng, J (Peng Jun) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 9 页 :
685-690 DOI: 10.1007/s11655-011-0846-4 出版年: SEP 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 23 摘要: To investigate the cellular effects of Pien Tze Huang (c parts per thousand double dagger a
>>"c (TM) Euro, PZH) in the HT-29 human colon carcinoma cell line.
The viability of HT-29 cells was determined by MTT assay. A fluorescence-activated cell sorting
(FACS) analysis with annexin-V/propidium iodide (PI) and JC-1 staining were performed to
determine cell apoptosis and the loss of mitochondrial membrane potential, respectively.
Activation of caspase 3 was evaluated by a colorimetric assay. The mRNA expression levels of
Bcl-2 and Bax were measured by reverse transcription polymerase chain reaction (RT-PCR).
PZH, in a dose- and timedependent manner, reduced viability and induced apoptosis of HT-29
cells. Moreover, PZH treatment resulted in the collapse of the mitochondrial membrane potential,
activation of caspase 3, and an increase in the Bax/Bcl-2 ratio.
PZH inhibits the growth of HT-29 cells by inducing cancer cell apoptosis via regulation of the
Bcl-2 family and activation of caspase 3, which may, in part, explain its anticancer activity. 入藏号: WOS:000294820500008 语种: English 文献类型: Article 作者关键词: Pien Tze Huang; Chinese medicine; colon cancer; apoptosis; HT-29 cells
KeyWords Plus: CHANNEL-FORMING ACTIVITY; CYTOCHROME-C; MITOCHONDRIA;
BAX; RELEASE; PROTEINS; CYTOSOL; SWITCH; DEATH 地址: Fujian Acad Integrat Med, Fuzhou 350108, Peoples R China
[Lin Jiu-mao; Wei Li-hui; Liu Xian-xiang; Hong Zhen-feng; Peng Jun] Fujian Acad Integrat Med,
Fuzhou 350108, Peoples R China
[Lin Jiu-mao; Liu Xian-xiang] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med
Geriatr, Fuzhou 350108, Peoples R China
[Chen You-qin; Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK
73190 USA
[Chen You-qin; Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol,
Oklahoma City, OK 73190 USA
[Peng Jun] Zhangzhou Pien Tze Huang Pharmaceut Co Ltd, Postdoctor Workstn, Zhangzhou
363000, Fujian, Peoples R China 通讯作者地址: Peng, J (通讯作者),Fujian Acad Integrat Med, Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA
Web of Science 分类: Integrative & Complementary Medicine 学科类别: Integrative & Complementary Medicine
IDS 号: 819JF
ISSN: 1672-0415
29 字符的来源出版物名称缩写: CHIN J INTEGR MED
ISO 来源出版物缩写: Chin. J. Integr. Med. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China 81073097
Developmental Fund of CHEN Ke-ji Integrative Medicine CKJ 2011001
Natural Science Foundation of Fujian Province of China 2010J01195
Supported by the National Natural Science Foundation of China (No. 81073097), the
Developmental Fund of CHEN Ke-ji Integrative Medicine (No. CKJ 2011001), and the Natural
Science Foundation of Fujian Province of China (No. 2010J01195)
第 27 条,共 86 条 标题: Fuzheng Yiliu Granule (ae parts per thousand ae aeSc pound similar to currency signe cent
uc(2)') inhibits the growth of hepatocellular cancer by regulating immune function and inducing
apoptosis in vivo and in vitro 作者: Cao, ZY (Cao Zhi-yun); Chen, XZ (Chen Xu-zheng); Liao, LM (Liao Lian-ming); Peng, J
(Peng Jun); Hu, HX (Hu Hai-xia); Liu, ZZ (Liu Zhi-zhen); Du, J (Du Jian) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 9 页 :
691-697 DOI: 10.1007/s11655-011-0847-3 出版年: SEP 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 25 摘要: To study the inhibitory effect of Fuzheng Yiliu Granule (ae parts per thousand ae aeSc
pound similar to currency signe cent uc(2)', FYG) on hepatocellular cancer (HCC) and investigate
the mechanism mediating its bioactivity.
H22 tumor-bearing ICR mice were treated with FYG [3.6 g/(kg center dot d)] for 5 days. Tumor
volume and tumor weight, percentages of CD3(+), CD4(+), CD8(+), and natural killer (NK) cells
in peripheral blood, tumor apoptosis and serum levels of interleukin-2 (IL-2), and tumor necrosis
factor-alpha (TNF-alpha) were evaluated. FYG-containing serum was prepared from SD rats
treated for 7 days [high dose 3.6 g/(kg center dot d); middle dose 1.8 g/(kg center dot d); low dose
0.9 g/(kg center dot d)]. Cell cycle, cell viability, and apoptosis were evaluated after HepG2 cell
line was cultured in FYG-containing serum for 48 h. The levels of IL-2 and TNF-alpha in
FYG-containing serum were also determined.
FYG produced a potent antitumor effect (P < 0.01) and induced marked apoptosis of the tumor
tissue (P < 0.05). Mice treated with FYG had higher percentages of CD3(+) and CD4(+) (P <
0.05), and more NK cells (P < 0.01) in the peripheral blood than those in the animals treated with
normal saline. Mice receiving FYG had the highest serum levels of IL-2 and TNF-alpha (P <
0.01). High-dose FYG-containing serum significantly decreased HepG2 cell viability, inhibited
cell proliferation (P < 0.05), and induced apoptosis (P < 0.01). In addition, the levels of IL-2 and
TNF-alpha of high-dose-containing serum were higher than the blank serum (P < 0.01).
FYG could inhibit HCC growth by regulating immune function and inducing apoptosis of tumor
cells in vivo and in vitro. 入藏号: WOS:000294820500009 语种: English 文献类型: Article 作者关键词: Fuzheng Yiliu Granule; hepatocellular cancer; immune function; apoptosis
KeyWords Plus: GANODERMA-LUCIDUM; TUMOR-METASTASIS; CARCINOMA;
LIGAND; INTERFERON; MECHANISMS 地址: [Cao Zhi-yun; Chen Xu-zheng; Liao Lian-ming; Peng Jun; Hu Hai-xia; Liu Zhi-zhen; Du
Jian] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Peoples R China 通讯作者地址: Du, J (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou
350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA
Web of Science 分类: Integrative & Complementary Medicine 学科类别: Integrative & Complementary Medicine
IDS 号: 819JF
ISSN: 1672-0415
29 字符的来源出版物名称缩写: CHIN J INTEGR MED
ISO 来源出版物缩写: Chin. J. Integr. Med. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构 授权号
CHEN Ke-ji Integrative Medicine Development Fund CKJ2010020
Ministry of Science and Technology of the People's Republic of China 2008DFA32200
Department of Education of Fujian Province JA09136
Supported by CHEN Ke-ji Integrative Medicine Development Fund (No. CKJ2010020);
International Science Joint Project of the Ministry of Science and Technology of the People's
Republic of China (No. 2008DFA32200); Project of Department of Education of Fujian Province
(No. JA09136)
第 28 条,共 86 条 标题: Potential synergistic and multitarget effect of herbal pair Chuanxiong Rhizome-Paeonia
Albifora Pall on osteoarthritis disease: A computational pharmacology approach 作者: Ye, HZ (Ye Hong-zhi); Zheng, CS (Zheng Chun-song); Xu, XJ (Xu Xiao-jie); Wu, MX (Wu
Ming-xia); Liu, XX (Liu Xian-xiang) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 9 页 :
698-703 DOI: 10.1007/s11655-011-0853-5 出版年: SEP 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 20 摘要: To study the polypharmacological mechanism of herbal pair Chuanxiong Rhizome-Paeonia
Albifora Pall (HP CXR-PAP) on the treatment for osteoarthritis (OA).
Chemical space was used to discuss the similarities and differences between the molecule sets of
HP CXR-PAP and drugs. Docking protocol was used to study the interaction between HP
CXR-PAP and OA target enzymes. The similarities and differences of HP CXR-PAP and drugs in
target spaces were elucidated by network features.
The plots between the molecule sets of HP CXR-PAP and drugs in chemical space had the
majority in the same region, and compounds from HP CXR-PAP covered a much larger additional
region of space than drug molecules, which denoted the diverse structural properties in the
molecule set of HP CXR-PAP. The molecules in HP CXR-PAP had the properties of promiscuous
drugs and combination drug, and both HP CXR-PAP ligand-target interaction network and drug
ligand-target interaction network were similar in the interaction profiles and network features,
which revealed the effects of multicomponent and multitarget.
The clue of potential synergism was obtained in curing OA disease by Chinese medicine, which
revealed the advantages of Chinese medicine for targeting osteoarthritis disease. 入藏号: WOS:000294820500010 语种: English 文献类型: Article 作者关键词: herbal pair Chuanxiong Rhizome-Paeonia Albifora Pall; chemical space; virtual
screening; target space; computational pharmacology; osteoarthritis
KeyWords Plus: TOUGU XIAOTONG GRANULE; INFLAMMATION; NETWORKS 地址: [Ye Hong-zhi; Zheng Chun-song; Wu Ming-xia; Liu Xian-xiang] Fujian Univ Tradit
Chinese Med, Fujian Acad Integrat Med, Fuzhou 350108, Peoples R China
[Xu Xiao-jie] Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
[Liu Xian-xiang] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med Geriatr, Fuzhou
350108, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med,
Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA
Web of Science 分类: Integrative & Complementary Medicine 学科类别: Integrative & Complementary Medicine
IDS 号: 819JF
ISSN: 1672-0415
29 字符的来源出版物名称缩写: CHIN J INTEGR MED
ISO 来源出版物缩写: Chin. J. Integr. Med. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China 81072826
CHEN Ke-ji Integrative Medicine Development Foundation CKJ2010032
Emphasis Foundation of Fujian Provincial Department of Science and 2010Y0029
Supported by the National Natural Science Foundation of China (No. 81072826), CHEN Ke-ji
Integrative Medicine Development Foundation (No. CKJ2010032), and Emphasis Foundation of
Fujian Provincial Department of Science and Technology (No. 2010Y0029)
第 29 条,共 86 条 标题: Millimeter wave treatment inhibits the mitochondrion-dependent apoptosis pathway in
chondrocytes 作者: Wu, GW (Wu, Guangwen); Sferra, T (Sferra, Thomas); Chen, XZ (Chen, Xuzheng); Chen,
YQ (Chen, Youqin); Wu, MX (Wu, Mingxia); Xu, HF (Xu, Huifeng); Peng, J (Peng, Jun); Liu,
XX (Liu, Xianxiang) 来源出版物 : MOLECULAR MEDICINE REPORTS 卷 : 4 期 : 5 页 : 1001-1006 DOI:
10.3892/mmr.2011.522 出版年: SEP-OCT 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 25 摘要: Millimeter wave (MW) is an electromagnetic wave with a wavelength between 1 and 10
mm and a frequency of 30-300 GHz that causes multiple biological effects, both locally and
globally. MW has been widely used in clinical medicine. Although our previous work
demonstrated that MW is capable of inhibiting sodium nitroprussiate (SNP)-induced apoptosis in
chondrocytes, the precise mechanism of the anti-apoptotic activity remains to be elucidated. The
purpose of this study was to investigate the effects of MW in SNP-induced apoptotic
chondrocytes. Sprague Dawley rat chondrocytes were isolated and cultured, and the cells were
counted. Cell viability was evaluated using MTT assay. Cells were then treated with SNP and
MW, and flow cytometry was used to detect apoptosis. Our results showed that MW treatment
inhibited a SNP-induced mitochondrion-dependent pathway of apoptosis. MW treatment inhibited
the loss of plasma membrane asymmetry (externalization of phosphatidylserine), collapse of
mitochondrial membrane potential, and activation of caspase-9 and caspase-3. Taken together, the
results indicate that MW inhibits the mitochondrion-dependent pathway of apoptosis in
chondrocytes and this may, in part, explain its clinical effect in the treatment of osteoarthritis. 入藏号: WOS:000293435300034 语种: English 文献类型: Article 作者关键词: chondrocyte; millimeter wave; apoptosis; mitochondria
KeyWords Plus: NO-INDUCED APOPTOSIS; CYTOCHROME-C; GENE-EXPRESSION;
RELEASE; MEMBRANE; DEATH; CELLS; BCL-2; BAX; OLIGOMERIZATION
地址: [Wu, Guangwen; Chen, Xuzheng; Wu, Mingxia; Peng, Jun; Liu, Xianxiang] Fujian Univ
Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Peoples R China
[Xu, Huifeng] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med Geriatr, Fuzhou
350108, Peoples R China
[Sferra, Thomas; Chen, Youqin] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK
73190 USA 通讯作者地址: Peng, J (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, 1
Huatuo Rd, Fuzhou 350108, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE
Web of Science 分类: Oncology; Medicine, Research & Experimental 学科类别: Oncology; Research & Experimental Medicine
IDS 号: 801JQ
ISSN: 1791-2997
29 字符的来源出版物名称缩写: MOL MED REP
ISO 来源出版物缩写: Mol. Med. Rep. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
Developmental Fund of Chen Keji Integrative Medicine CKJ2010023
Fujian Province Small Creations and Projects
This work was supported by the Developmental Fund of Chen Keji Integrative Medicine
(CKJ2010023) and 2008 Fujian Province Small Creations and Projects (no.1).
第 30 条,共 86 条 标题: Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in
MG-63 osteosarcoma cells 作者: Liang, WN (Liang, Wenna); Li, XH (Li, Xihai); Li, CD (Li, Candong); Liao, LM (Liao,
Lianming); Gao, BZ (Gao, Bizheng); Gan, HJ (Gan, Huijuan); Yang, ZY (Yang, Zhaoyang); Liao,
LH (Liao, Linghong); Chen, XZ (Chen, Xuzheng) 来源出版物 : MOLECULAR MEDICINE REPORTS 卷 : 4 期 : 5 页 : 1017-1023 DOI:
10.3892/mmr.2011.533 出版年: SEP-OCT 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 29 摘要: Quercetin (a natural polyphenolic compound) is a polyphenolic flavonoid compound found
in a variety of plants. It has been demonstrated to exert cytostatic activity against a variety of
human cancer cell lines, including the human osteosarcoma cell line, MG-63. However, its effects
on osteosarcoma cell apoptosis are still undefined. The present study was undertaken to examine
the effect of quercetin on cell viability, apoptosis and mitochondrial membrane potential, and to
determine the molecular mechanism of quercetininduced apoptosis by investigating the expression
of Bcl-2 family proteins (Bcl-2, Bax), cytochrome C, caspase-9 and caspase-3 in MG-63 cells. We
found that quercetin suppressed the viability of MG-63 cells in a dose- and time- dependent
manner. Furthermore, we observed that quercetin induced the loss of mitochondrial membrane
potential, upregulated the expression of the proapoptotic proteins, Bax and cytochrome C, and
activated caspase-9 and caspase-3, and downregulated the expression of antiapoptotic protein,
Bcl-2. These data suggest that quercetin may induce apoptosis via the mitochondrial-dependent
pathway in MG-63 cells. 入藏号: WOS:000293435300036 语种: English 文献类型: Article 作者关键词: osteosarcoma; apoptosis; quercetin; mitochondria
KeyWords Plus: CANCER PREVENTION; BCL-2 FAMILY; DEATH; BAX; INHIBITION;
MECHANISMS; PROTEINS; THERAPY; MTDNA 地址 : [Liang, Wenna; Li, Candong; Gao, Bizheng; Gan, Huijuan; Yang, Zhaoyang; Liao,
Linghong] Fujian Univ Tradit Chinese Med, Res Base TCM Syndrome, Fuzhou 350108, Fujian,
Peoples R China
[Li, Xihai; Liao, Lianming; Chen, Xuzheng] Fujian Univ Tradit Chinese Med, Acad Integrat Med,
Fuzhou 350108, Fujian, Peoples R China 通讯作者地址: Li, CD (通讯作者),Fujian Univ Tradit Chinese Med, Res Base TCM Syndrome, 1
Huatuo Rd, Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE
Web of Science 分类: Oncology; Medicine, Research & Experimental 学科类别: Oncology; Research & Experimental Medicine
IDS 号: 801JQ
ISSN: 1791-2997
29 字符的来源出版物名称缩写: MOL MED REP
ISO 来源出版物缩写: Mol. Med. Rep. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China 30772697
This study was supported by the National Natural Science Foundation of China (Grant no.
30772697).
第 31 条,共 86 条 标题: A review of chemistry and bioactivities of a medicinal spice: Foeniculum vulgare 作者: He, WP (He, Weiping); Huang, BK (Huang, Baokang) 来源出版物 : JOURNAL OF MEDICINAL PLANTS RESEARCH 卷 : 5 期 : 16 页 :
3595-3600 出版年: AUG 18 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 51 摘要: Foeniculum vulgare Mill. with common name fennel, is a very popular spice as well as an
important traditional Chinese medicine. The plant is native to Southern Europe and Mediterranean
region. It has two important subspecies of Capillaceum and Piperitum. It mainly contains essential
oil, fatty acids and phenolic compounds, etc. The most intense odor compounds of fennel are
trans-anethole, estragole and fenchone. Fennel has many biological activities due to its volatile
and nonvolatile compounds, and it has been used in traditional Chinese medicine for treating
various conditions, particularly rheumatism, cold pain and stomach disorder. It is also used as a
spice for its aromatic fruit. This review covers progresses on the chemistry, pharmacology and
nutraceutical value of fennel, and aims to lay the foundation for further study and utilization of
fennel. 入藏号: WOS:000297463900004 语种: English 文献类型: Review 作者关键词: Chemistry; bioactivity; Foeniculum vulgare
KeyWords Plus: ESSENTIAL OIL COMPOSITION; STORED-PRODUCT INSECTS;
ACARICIDAL ACTIVITY; TYROPHAGUS-PUTRESCENTIAE; ANTIOXIDANT
ACTIVITIES; CHEMICAL-COMPOSITION; LARVICIDAL ACTIVITY; VOLATILE OIL;
SEED OILS; FENNEL 地址: [He, Weiping; Huang, Baokang] Mil Med Coll 2, Sch Pharm, Shanghai 200433, Peoples R
China
[He, Weiping] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350108, Peoples R China 通讯作者地址: He, WP (通讯作者),Mil Med Coll 2, Sch Pharm, Shanghai 200433, Peoples R
China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
Web of Science 分类: Chemistry, Medicinal 学科类别: Pharmacology & Pharmacy
IDS 号: 853ZJ
ISSN: 1996-0875
29 字符的来源出版物名称缩写: J MED PLANTS RES
ISO 来源出版物缩写: J. Med. Plants Res. 来源出版物页码计数: 6
第 32 条,共 86 条 标题: Tetramethylpyrazine (TMP) promotes chondrocyte proliferation via pushing the progression
of cell cycle 作者: Li, XH (Li, Xihai); Peng, J (Peng, Jun); Xu, YF (Xu, Yanfang); Wu, MX (Wu, Mingxia);
Ye, HZ (Ye, Hongzhi); Zheng, CS (Zheng, Chunsong); Wu, GW (Wu, Guangwen); Xu, HF (Xu,
Huifeng); Chen, XZ (Chen, Xuzheng); Liu, XX (Liu, Xianxiang) 来源出版物 : JOURNAL OF MEDICINAL PLANTS RESEARCH 卷 : 5 期 : 16 页 :
3896-3903 出版年: AUG 18 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 27 摘要: Tetramethylpyrazine (TMP) is the major bioactive constituent of Rhizoma Chuanxiong
which has long been used as an important component in several Chinese medicine formulations
for the clinical treatment of osteoarthritis. However, the molecular mechanism of the therapeutic
effect of TMP remains unclear. In the present study, we investigated the cellular effects of TMP in
cultured primary chondrocytes. Chondrocytes isolated from the knee articular cartilage of SD rats
were cultured and identified using toluidine blue staining. The second generation of chondrocytes
was treated with or without TMP. We found that TMP treatment could promote chondrocyte
proliferation via pushing the progression of cell cycle. Furthermore, using RT-PCR and Western
blotting analyses we observed that the mRNA and protein levels of Cyclin D1 and CDK4 were
significantly enhanced after TMP treatment, whereas those of p21 were significantly decreased.
Our study suggests that promoting the proliferation of chondrocytes is one of the mechanisms by
which TMP treats osteoarthritis. 入藏号: WOS:000297463900050 语种: English 文献类型: Article 作者关键词: Tetramethylpyrazine; chondrocyte; osteoarthritis; cell cycle
KeyWords Plus: MESENCHYMAL STEM-CELLS; CHONDROGENIC DIFFERENTIATION;
ARTICULAR CHONDROCYTES; ENDOTHELIAL-CELLS; MODULATION; EXPRESSION;
DEGRADATION; TRANSITION; CARTILAGE; DAMAGE 地址: [Li, Xihai; Peng, Jun; Ye, Hongzhi; Zheng, Chunsong; Wu, Guangwen; Xu, Huifeng; Chen,
Xuzheng; Liu, Xianxiang] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108,
Peoples R China
[Li, Xihai] Fujian Key Lab Integrat Med Geriatr, Fuzhou 350108, Peoples R China
[Xu, Yanfang] Fujian Med Univ, Affiliated Hosp 1, Fuzhou 350005, Peoples R China
[Wu, Mingxia] Fujian Univ Tradit Chinese Med, Hosp 2, Dept Acupuncture & Moxibust, Fuzhou
350003, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou
350108, Peoples R China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
Web of Science 分类: Chemistry, Medicinal 学科类别: Pharmacology & Pharmacy
IDS 号: 853ZJ
ISSN: 1996-0875
29 字符的来源出版物名称缩写: J MED PLANTS RES
ISO 来源出版物缩写: J. Med. Plants Res. 来源出版物页码计数: 8 基金资助致谢: 基金资助机构 授权号
Foundation of Fujian Provincial Administration of Science and Technology 2009Y0029
National Natural Science Foundation of China 81072826
This work was supported by the Project supported by the Major Project Foundation of Fujian
Provincial Administration of Science and Technology (No. 2009Y0029), the National Natural
Science Foundation of China (No. 81072826).
第 33 条,共 86 条 标题: Volatile components of fruits of Ligustrum lucidum Ait. stimulate proliferation and
differentiation of rat calvarial osteoblasts 作者: Wu, YB (Wu, Yan-Bin); Lin, XH (Lin, Xiong-Hao); Wu, JG (Wu, Jian-Guo); Yi, J (Yi, Jun);
Zheng, YZ (Zheng, Yan-Zhi); Wu, JZ (Wu, Jin-Zhong) 来源出版物: AFRICAN JOURNAL OF BIOTECHNOLOGY 卷: 10 期: 43 页: 8662-8668 出版年: AUG 10 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 30 摘要: The fruits of Ligustrum lucidum Ait., (FLL), which contain rich volatile components, are
commonly used as tonic for kidney and liver in the traditional Chinese medicine prescriptions.
This study aimed to investigate the effects of volatile components of FLL on the proliferation and
differentiation of rat calvarial osteoblasts by the MTT method and measuring the activity of
alkaline phosphatase (ALP). Results showed that volatile components (1 to 100 mu g/mL) of FLL
significantly (p<0.01) stimulated the proliferation and increased the ALP activity of rat calvarial
osteoblasts which indicated that volatile components of FLL played an important role in
osteoblastic bone formation just as non-volatile components in FLL. Such finding accredited the
FLL as a potential candidate that might be useful in bone engineering and in treating bone defects
including osteoporosis. The volatile components were analyzed by GC-MS. A total of 67
compounds were identified and the main components included (Z,Z)-9,12-octadecadienoic acid
(33.47%), n-hexadecanoic acid (15.02%), (E)-9-octadecenoic acid (9.03%), alpha-cadinol
(6.51%), 4-hexyl-2,5-dihydro-2,5-dioxo-3-furanacetic acid (4.93%) and (E)-8-octadecenoic acid
methyl ester (2.69%). 入藏号: WOS:000294679900018 语种: English 文献类型: Article 作者关键词: Ligustrum lucidum; volatile components; rat calvarial osteoblasts
KeyWords Plus: POLYUNSATURATED FATTY-ACIDS; OVARIECTOMIZED RATS;
IN-VITRO; BONE; OSTEOPOROSIS; EXTRACT; SUPPLEMENTATION; OSTEOCLASTS;
EXPRESSION; OILS 地址: [Wu, Yan-Bin; Lin, Xiong-Hao; Wu, Jian-Guo; Zheng, Yan-Zhi; Wu, Jin-Zhong] Fujian
Univ Tradit Chinese Med, Fuzhou 350108, Fujian, Peoples R China
[Yi, Jun] Fujian Inst Educ, Dept Chem & Life Sci, Fuzhou 350001, Fujian, Peoples R China 通讯作者地址: Wu, JZ (通讯作者),Fujian Univ Tradit Chinese Med, Fuzhou 350108, Fujian,
Peoples R China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
Web of Science 分类: Biotechnology & Applied Microbiology 学科类别: Biotechnology & Applied Microbiology
IDS 号: 817NF
ISSN: 1684-5315
29 字符的来源出版物名称缩写: AFR J BIOTECHNOL
ISO 来源出版物缩写: Afr. J. Biotechnol. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构 授权号
Fujian Provincial Universities for Haixi Development
Department of Education Fujian Province JA10181
Fujian Key Laboratory of Integrative Medicine on Geriatrics (Fujian University
of TCM) 2008J1004-42
Natural Science Foundation of Fujian province 2011J01214
This work was conducted in Class III Laboratory of Traditional Chinese Medicine on
Pharmacognosy of State Administration of Traditional Chinese Medicine of People's Republic of
China and was financially supported by Key Project of Fujian Provincial Universities for Haixi
Development (Grant No. 5), Fund of Department of Education Fujian Province (Grant No.
JA10181), Open Fund of Fujian Key Laboratory of Integrative Medicine on Geriatrics (Fujian
University of TCM) (Grant No. 2008J1004-42) as well as Research supported by the Natural
Science Foundation of Fujian province (No. 2011J01214).
第 34 条,共 86 条 标题 : Determination of Fulvestrant in Rat Plasma by LC-MS-MS: Application to a
Pharmacokinetic Study 作者: Liu, ZY (Liu, Zhongyang); Gu, GZ (Gu, Guangzhi); Xia, HM (Xia, Huimin); Liu, Q (Liu,
Qiang); Pang, ZQ (Pang, Zhiqing); Jiang, XG (Jiang, Xinguo); Chen, J (Chen, Jun) 来 源 出 版 物 : CHROMATOGRAPHIA 卷 : 74 期 : 3-4 页 : 227-234 DOI:
10.1007/s10337-011-2071-x 出版年: AUG 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 7 摘要 : A reversed-phase liquid chromatography coupled to tandem mass spectrometry
(LC-MS-MS) method was developed and validated for the determination of fulvestrant in rat
plasma. Sample preparation involved a liquid-liquid extraction using 1.0 mL of
n-hexane-isopropanol (90:10, v/v) to extract the analyte from 0.1 mL of rat plasma. The analytes
were separated on a phenyl-based column using the mobile phase consisting of methanol/water
containing 5 mM ammonium acetate at the flow rate of 0.3 mL min(-1). The analytes were
monitored by tandem mass spectrometry under electrospray negative ionization mode. Linear
calibration curves were generated over the fulvestrant concentration ranges of 0.05-10.0 ng
mL(-1) in rat plasma. The accuracy and within-and between-day precisions were within the
generally accepted criteria for bioanalytical methods (<15%). This developed and validated assay
method was successfully employed to characterize the plasma concentration-time profile of
fulvestrant after its intramuscular administration in rats at a dose of 10 mg kg(-1). 入藏号: WOS:000294068100006 语种: English 文献类型: Article 作者关键词: LC-MS-MS; Fulvestrant; Pharmacokinetics
KeyWords Plus: BREAST-CANCER; ENDOCRINE THERAPY; WOMEN 地址: [Liu, Zhongyang; Gu, Guangzhi; Xia, Huimin; Pang, Zhiqing; Jiang, Xinguo; Chen, Jun]
Fudan Univ, Dept Pharmaceut, Sch Pharm, Shanghai 201203, Peoples R China
[Liu, Qiang] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350108, Peoples R China 通讯作者地址: Chen, J (通讯作者),Fudan Univ, Dept Pharmaceut, Sch Pharm, Shanghai 201203,
Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER HEIDELBERG 出版商地址: TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
Web of Science 分类: Biochemical Research Methods; Chemistry, Analytical 学科类别: Biochemistry & Molecular Biology; Chemistry
IDS 号: 809PB
ISSN: 0009-5893
29 字符的来源出版物名称缩写: CHROMATOGRAPHIA
ISO 来源出版物缩写: Chromatographia 来源出版物页码计数: 8 基金资助致谢: 基金资助机构 授权号
National Key Basic Research Program of the People's Republic of China 2007CB935800
National Science and Technology Major Project 2009ZX09310-006
This work was partly financially supported by a project of the "National Key Basic Research
Program of the People's Republic of China" (no. 2007CB935800) and a project of the "National
Science and Technology Major Project" (no. 2009ZX09310-006).
第 35 条,共 86 条 标题: Analysis of thrombin-antithrombin complex contents in plasma and hematoma fluid of
hypertensive intracerebral hemorrhage patients after clot removal 作者: Wu, CH (Wu, C. -H.); Yang, RL (Yang, R. -L.); Huang, SY (Huang, S. -Y.); Li, HZ (Li, H.
-Z.); Wang, KY (Wang, K. -Y.); Yang, DH (Yang, D. -H.); Yan, XH (Yan, X. -H.); Xue, XH (Xue,
X. -H.); Wu, SY (Wu, S. -Y.); Wang, JM (Wang, J. -M.); Lin, JS (Lin, J. -S.); Liao, LM (Liao, L.
-M.); Chen, LD (Chen, L. -D.) 来源出版物: EUROPEAN JOURNAL OF NEUROLOGY 卷: 18 期: 8 页: 1060-1066 DOI:
10.1111/j.1468-1331.2010.03336.x 出版年: AUG 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 21 摘要: Background and purpose: Animal experiments indicate that the cerebral thrombin is
associated with secondary brain damage after intracerebral hemorrhage (ICH). This study was
aimed to investigate the concentrations of thrombin-antithrombin complex (TAT) in hematoma
fluid and plasma of the patients with ICH after surgery and analyze the correlation between TAT
complex levels and severity of ICH.
Methods: Sixty patients with ICH were enrolled. Craniotomy for removal of intracranial blood
clot was performed within 24 h after ICH. Hematoma fluid and plasma were collected on
postoperative days 1, 2, and 4. The plasma obtained from healthy subjects and cerebrospinal fluid
from patients without cerebrovascular diseases served as controls, respectively. Enzyme-linked
immunosorbent assay was used to determine the concentrations of TAT complex in the patients
and controls.
Results: TAT complex concentrations in both postoperative plasma and hematoma fluid of patients
with ICH were significantly higher than those of the controls (P < 0.01). In patients with ICH,
hematoma fluid had a higher TAT complex level than plasma (P < 0.01). The preoperative
hemorrhage volume and postoperative TAT complex levels in plasma and hematoma fluid
correlated positively with National Institutes of Health stroke scale and negatively with Glasgow
coma score (P < 0.01).
Conclusion: This study indicates that TAT complex levels of plasma and hematoma fluid correlate
positively with the severity of ICH. Determination of the plasma TAT complex concentration is
helpful for the evaluation of the severity of post-ICH brain injury. 入藏号: WOS:000292699900014 语种: English 文献类型: Article 作者关键词: antithrombin III-protease complex; cerebral hematoma fluid; glasgow coma scale;
national institutes of health stroke scale; plasma
KeyWords Plus: EDEMA DEVELOPMENT; BRAIN EDEMA; STROKE; MODEL;
MECHANISMS 地址: [Wu, C. -H.; Yang, R. -L.; Xue, X. -H.; Wu, S. -Y.; Wang, J. -M.; Lin, J. -S.; Liao, L. -M.;
Chen, L. -D.] Fujian Univ Tradit Chinese Med, Affiliated Clin Coll 2, Dept Neurol, Fuzhou
350003, Peoples R China
[Huang, S. -Y.; Wang, K. -Y.; Yan, X. -H.] Fujian Prov Hosp, Dept Neurosurg, Fuzhou, Peoples R
China
[Li, H. -Z.; Yang, D. -H.] Fujian Univ Tradit Chinese Med, Affiliated Clin Coll 2, Dept Neurosurg,
Fuzhou 350003, Peoples R China 通讯作者地址: Wu, CH (通讯作者),Fujian Univ Tradit Chinese Med, Affiliated Clin Coll 2, Dept
Neurol, Fuzhou 350003, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Web of Science 分类: Clinical Neurology; Neurosciences 学科类别: Neurosciences & Neurology
IDS 号: 791WR
ISSN: 1351-5101
29 字符的来源出版物名称缩写: EUR J NEUROL
ISO 来源出版物缩写: Eur. J. Neurol. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构 授权号
Fujian Provincial Department of Health WZY0622
Fujian Provincial Natural Science Fund 2006J0106
This work was supported by the Scientific Research Fund of Fujian Provincial Department of
Health (No. WZY0622) and Fujian Provincial Natural Science Fund (No. 2006J0106). We thank
Shanghai Institute of Immunology (China) for providing research equipment and Dr. Tom
Lonsdale (Australia), and Dr. Jie Liu for their assistance during the drafting of the manuscript.
第 36 条,共 86 条 标题: Lipoprotein-associated phospholipase A2 gene V279F polymorphisms and coronary heart
disease: a meta-analysis 作者 : Zheng, GH (Zheng, Guo-Hua); Chen, HY (Chen, Hai-Ying); Xiong, SQ (Xiong,
Shang-Quan); Chu, JF (Chu, Jian-Feng) 来源出版物 : MOLECULAR BIOLOGY REPORTS 卷 : 38 期 : 6 页 : 4089-4099 DOI:
10.1007/s11033-010-0529-9 出版年: AUG 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 41 摘要: Lipoprotein-associated phospholipase A2 (LP-PLA2) may play an important role in the
pathophysiology of coronary heart disease (CHD). The polymorphism of LP-PLA2 gene caused
LP-PLA2 enzyme activity depressing or lost. But there is not a definite conclusion for the
association of between the LP-PLA2 gene polymorphism and CHD risk. To assess the relationship
between LP-PLA2 gene V279F polymorphism and CHD, a comprehensive Meta-analysis was
performed. All the case-control studies evaluating the association of between the LP-PLA2 gene
V279F polymorphism and CHD risk were identified. Seven case-control studies involving 3,614
patients with CHD and 4,334 controls were included. The crude odds ratios (ORs) of
meta-analysis under the different gene model were not significant. But in the stratified analysis by
study size, ethnicity, cases definition, and source of controls under the additive model, the
association was evident in ethnicity for Japanese group (OR = 1.38, 95%CI = 1.22-1.56), cases
definition for MI (OR = 1.22, 95%CI = 1.01-1.49), source of controls for the based-hospital (OR =
1.42, 95%CI = 1.24-1.59). These data suggested that the V279F polymorphism in LP-PLA2 gene
may contribute to CHD development. But there is necessary that more well-designed large studies
are required for the validation of this association. 入藏号: WOS:000291656800058 语种: English 文献类型: Article 作者关键词: Lipoprotein-associated phospholipase A2 (LP-PLA2); Coronary heart disease;
Genetic polymorphism; Meta-analysis
KeyWords Plus: ACTIVATING-FACTOR-ACETYLHYDROLASE; ARTERY-DISEASE;
RISK-FACTOR; CARDIOVASCULAR HEALTH; MYOCARDIAL-INFARCTION;
PAF-ACETYLHYDROLASE; LUDWIGSHAFEN RISK; MISSENSE MUTATION;
ATHEROSCLEROSIS; INFLAMMATION 地址: [Xiong, Shang-Quan] Peoples Hosp Fujian Prov, Fuzhou, Peoples R China
[Zheng, Guo-Hua] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China
通讯作者地址: Zheng, GH (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, Ctr
Evidence Based Med, 1 Huatuo Rd, Fuzhou, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
Web of Science 分类: Biochemistry & Molecular Biology 学科类别: Biochemistry & Molecular Biology
IDS 号: 777WW
ISSN: 0301-4851
29 字符的来源出版物名称缩写: MOL BIOL REP
ISO 来源出版物缩写: Mol. Biol. Rep. 来源出版物页码计数: 11 基金资助致谢: 基金资助机构 授权号
natural science foundation of Fujian province 2009J01163
foundation of Chen Ke-Ji Academician CKJ2009002
Funding was provided by the natural science foundation of Fujian province (no. 2009J01163.
Fujian Provincial department of Science & Technology, Fujian, China) and the foundation of Chen
Ke-Ji Academician (no. CKJ2009002. Academy of Integrative Medicine, Fujian, China).
第 37 条,共 86 条 标题 : Inhibition of tumor angiogenesis by Scutellaria barbata D. Don via suppressing
proliferation, migration and tube formation of endothelial cells and downregulation of the
expression of VEGF-A in cancer cells 作者: Wei, LH (Wei, Lihui); Lin, JM (Lin, Jiumao); Xu, W (Xu, Wei); Hong, ZF (Hong,
Zhenfeng); Liu, XX (Liu, Xianxiang); Peng, J (Peng, Jun) 来源出版物 : JOURNAL OF MEDICINAL PLANTS RESEARCH 卷 : 5 期 : 14 页 :
3260-3268 出版年: JUL 18 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 30 摘要: Scutellaria barbata D. Don is a medicinal herb that has long been clinically used in China to
treat various types of cancer. Extracts of S. barbata D. Don have been shown to inhibit the growth
of many cancer cells. Previously, we reported that S. barbata D. Don promotes cancer cell
apoptosis via activation of the mitochondrion-dependent pathway. To further elucidate the precise
mechanism of its tumorcidal activity, we investigated the effects of ethanol extract of S. barbata D.
Don (EESB) on tumor angiogenesis. We found that EESB inhibited angiogenesis in vivo in chick
embryo chorioallantoic membrane (CAM). In addition, we observed that EESB dose and
time-dependently inhibited the proliferation of human umbilical vein endothelial cells (HUVEC)
via blocking the cell cycle G1 to S progression. Moreover, EESB inhibited the migration and tube
formation of HUVECs. Furthermore, EESB treatment down-regulated the mRNA and protein
expression levels of VEGF-A in both HT-29 human colon carcinoma cells and HUVECs. Our
findings suggest that inhibiting tumor angiogenesis is one of the mechanisms by which S. barbata
D. Don treats cancer. 入藏号: WOS:000299749400045 语种: English 文献类型: Article 作者关键词: Tumor angiogenesis; traditional Chinese medicine; multi-target agents; Scutellaria
barbata D. Don
KeyWords Plus: GROWTH-FACTOR EXPRESSION; THERAPEUTIC IMPLICATIONS;
NATURAL-PRODUCTS; CARCINOMA; PATHWAY; METASTASIS; MECHANISMS;
APOPTOSIS 地址: [Wei, Lihui; Lin, Jiumao; Hong, Zhenfeng; Peng, Jun] Fujian Univ Tradit Chinese Med,
Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China
[Xu, Wei] Fujian Univ Tradit Chinese Med, Dept Pharmacol, Fuzhou 350108, Fujian, Peoples R
China
[Liu, Xianxiang] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med Geriatr, Fuzhou
350108, Fujian, Peoples R China 通讯作者地址: Peng, J (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, 1
Huatuo Rd, Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
Web of Science 分类: Chemistry, Medicinal 学科类别: Pharmacology & Pharmacy
IDS 号: 885AG
ISSN: 1996-0875
29 字符的来源出版物名称缩写: J MED PLANTS RES
ISO 来源出版物缩写: J. Med. Plants Res. 来源出版物页码计数: 9 基金资助致谢: 基金资助机构 授权号
Developmental Fund of Chen Keji Integrative Medicine CKJ 2010019
National Natural Science Foundation of China 81073097
Natural Science Foundation of Fujian Province of China 2010J01195
Research Foundation of Education Bureau of Fujian Province of China JA10162
This work was sponsored by the Developmental Fund of Chen Keji Integrative Medicine (CKJ
2010019), the National Natural Science Foundation of China (81073097), the Natural Science
Foundation of Fujian Province of China (2010J01195), and the Research Foundation of Education
Bureau of Fujian Province of China (JA10162).
第 38 条,共 86 条 标题: Oleanolic acid inhibits hypertrophic scarring in the rabbit ear model 作者: Wei, YJ (Wei, Y. -J.); Yan, XQ (Yan, X. -Q.); Ma, L (Ma, L.); Wu, JG (Wu, J. -G.); Zhang, H
(Zhang, H.); Qin, LP (Qin, L. -P.) 来源出版物 : CLINICAL AND EXPERIMENTAL DERMATOLOGY 卷 : 36 期 : 5 页 :
528-533 DOI: 10.1111/j.1365-2230.2010.04012.x 出版年: JUL 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 16 摘要: Background. Hypertrophic scarring, a common proliferative disorder of dermal fibroblasts,
results from an overproduction of collagen and excessive deposition of extracellular matrix.
Although treatment with surgical excision or steroid hormones can modify the symptoms,
numerous treatment-related complications have been described.
Aim. To investigate the effects of oleanolic acid (OA). a naturally occurring triterpenoid, on
hypertrophic scarring in a rabbit ear model.
Methods. A rabbit ear model of hypertrophic scarring was used, with wounds produced with a
biopsy punch. Oleanolic acid (2.5%, 5% and 10%) was applied once daily to the scars for 22 days.
On postoperative day 28, the scars were excised, and the tissue used for histological examination
and assays of the levels of collagens I and III matrix metalloproteinase (MMP)-1 and transforming
growth factor (TGF)-beta(1). The scar elevation index (SEI) was also determined.
Results. Treatment with different concentrations of oleanolic acid (OA) for 22 days significantly
inhibited hypertrophic scarring in rabbit ear tissue. Levels of TGF-beta(1). collagen I and collagen
III were significantly decreased and levels of MMP-1 significantly increased in the scar tissue.
SEI was also significantly reduced. Histological findings showed significant amelioration of the
scar tissue.
Conclusions. OA suppresses hypertrophic scarring in the rabbit ear model and may be an effective
cure for human hypertrophic scarring. 入藏号: WOS:000292659600016 语种: English 文献类型: Article
KeyWords Plus: POLYGONUM-CUSPIDATUM; EXPRESSION; POLYDATIN; SCARS; LIFE 地址: [Wei, Y. -J.; Wu, J. -G.; Zhang, H.; Qin, L. -P.] Mil Med Coll 2, Sch Pharm, Dept
Pharmacognosy, Shanghai, Peoples R China
[Wei, Y. -J.] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou, Peoples R China
[Yan, X. -Q.] Mil Med Coll 2, Changhai Hosp, Dept Anaesthesiol, Shanghai, Peoples R China
[Ma, L.] Capital Med Univ, Sch Tradit Chinese Med, Beijing, Peoples R China
通讯作者地址: Zhang, H (通讯作者),325 Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Web of Science 分类: Dermatology 学科类别: Dermatology
IDS 号: 791IT
ISSN: 0307-6938
29 字符的来源出版物名称缩写: CLIN EXP DERMATOL
ISO 来源出版物缩写: Clin. Exp. Dermatol. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
Shanghai Committee of Science and Technology 08JC1405700
This work was supported by a grant from the Key Programs for Basic Research of Shanghai
Committee of Science and Technology (Grant no. 08JC1405700).
第 39 条,共 86 条 标题: BMP2 promotes chondrocyte proliferation via the Wnt/beta-catenin signaling pathway 作者: Li, XH (Li, Xihai); Peng, J (Peng, Jun); Wu, MX (Wu, Mingxia); Ye, HZ (Ye, Hongzhi);
Zheng, CS (Zheng, Chunsong); Wu, GW (Wu, Guangwen); Xu, HF (Xu, Huifeng); Chen, XZ
(Chen, Xuzheng); Liu, XX (Liu, Xianxiang) 来源出版物 : MOLECULAR MEDICINE REPORTS 卷 : 4 期 : 4 页 : 621-626 DOI:
10.3892/mmr.2011.474 出版年: JUL-AUG 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 23 摘要: Bone morphogenetic protein 2 (BMP2), a member of the transforming growth factor-beta
(TGF-beta) superfamily, plays a key role in the induction of the differentiation of mesenchymal
cells into chondrocytes to form cartilage tissue. However, it is not clear whether BMP2 regulates
the proliferation of chondrocytes. In the present study, the effect of BMP2 on the proliferation of
chondrocytes and its underlying mechanism was investigated. Chondrocytes isolated from the
knee of SD rats were cultured and identified using toluidine blue staining. The second generation
chondrocytes were collected and stimulated with or without BMP2 for 48 h. Cell viability was
analyzed using the MTT assay. mRNA and protein expression levels of beta-catenin, GSK-3 beta,
Dvl1 and Cyclin D1 were detected using real-time RT-PCR and Western blotting, respectively.
The cell cycle distribution of the chondrocytes was analyzed by flow cytometry. BMP2
stimulation was found to significantly increase cell viability. In addition, following BMP2
treatment, beta-catenin, Cyclin D1 and Dvl1 expression was significantly increased, whereas
GSK-3 beta expression was significantly decreased. Moreover, the percentage proportion of
chondrocytes in the G0/G1 phase was significantly decreased, whereas that in the S phase was
significantly increased. The results indicate that BMP2 promotes chondrocyte proliferation via the
Wnt/beta-catenin signaling pathway. 入藏号: WOS:000291525900007 语种: English 文献类型: Article 作者关键词: bone morphogenetic protein 2; chondrocyte; cell cycle; osteoarthritis
KeyWords Plus: ARTICULAR CHONDROCYTES; OSTEOARTHRITIS; EXPRESSION;
CARTILAGE; DIFFERENTIATION; DEGENERATION; CULTURES; MATRIX 地址: [Li, Xihai; Peng, Jun; Wu, Mingxia; Ye, Hongzhi; Zheng, Chunsong; Wu, Guangwen; Liu,
Xianxiang] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Peoples R
China
[Xu, Huifeng; Chen, Xuzheng] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med
Geriatr, Fuzhou 350108, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, 1
Huatuo, Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE
Web of Science 分类: Oncology; Medicine, Research & Experimental 学科类别: Oncology; Research & Experimental Medicine
IDS 号: 776HU
ISSN: 1791-2997
29 字符的来源出版物名称缩写: MOL MED REP
ISO 来源出版物缩写: Mol. Med. Rep. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
Keji Chen Development Foundation for Integrated Traditional and Western
Medicine CKJ2008003
2008 Fujian Province Small Creations and Projects
This study was supported by a grant from the Keji Chen Development Foundation for Integrated
Traditional and Western Medicine (no. CKJ2008003) and the 2008 Fujian Province Small
Creations and Projects (no. 1).
第 40 条,共 86 条
标题: Effects and mechanisms of actions of Chinese herbal medicines for asthma 作者: Hong, ML (Hong Min-li); Song, Y (Song Ying); Li, XM (Li Xiu-min) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 7 页 :
483-491 DOI: 10.1007/s11655-011-0780-5 出版年: JUL 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 41 摘要: Asthma is a chronic inflammatory disorder of airways that affects approximately 300
million adults and children worldwide. Most therapy currently uses bronchodilators and
corticosteroids. Systemic side effects from chronic use of these drugs are concern. Chinese
medicine (CM) has a long history of human use in China and other Asian countries and well
received by the patients. But as one component of Western integrative medicine (WIM), it is
required that CM use is supported by scientific evidence. On the other hand, there are also
suggestions that Western standardized medicine should consider personalized practice. In recent
years there have been an increasing studies to narrow the gap between CM, the personalized
medicine and Western medicine, evidence based medicine. This communication reviews several
CM studies published in the English language in details by reviewing the effects and mechanisms
of actions on asthma from clinic and experimental studies.
Chinese herbal medicines exhibit broad actions on multiple asthma pathologic mechanisms. These
mechanisms may involve antiinflammatory and immunomodulatory effects, inhibiting airway
remodeling and normalization of hypothalamus, pituitary and adrenal (HPA)-axis disturbances.
However, the mechanisms of actions of Chinese herbal medicines for asthma are not fully
understood. More controlled clinical studies are warranted and some anti-asthma CM may be
proved to be effective when used as monotherapy or complementary asthma therapies. 入藏号: WOS:000292305400001 语种: English 文献类型: Article 作者关键词: asthma; complementary and alternative medicine; Chinese medicine; Chinese herbal
medicine; mechanism of action
KeyWords Plus: KAPPA-B PATHWAY; ALLERGIC-ASTHMA; AIRWAY INFLAMMATION;
INHALED CORTICOSTEROIDS; INTERFERON-GAMMA; IN-VITRO; INHIBITION;
MODEL; INTERVENTION; CHILDREN 地址: [Hong Min-li; Song Ying; Li Xiu-min] Mt Sinai Sch Med, Ctr Chinese Med Allergy &
Asthma, Jaffe Food Allergy Inst, Pediat Dept,Div Allergy & Immunol, New York, NY 10029 USA
[Hong Min-li] Fujian Univ Tradit Chinese Med, Resp Dept, Zhangzhou Tradit Chinese Med Hosp,
Affiliated Hosp, Zhangzhou 363000, Peoples R China 通讯作者地址: Li, XM (通讯作者),Mt Sinai Sch Med, Ctr Chinese Med Allergy & Asthma, Jaffe
Food Allergy Inst, Pediat Dept,Div Allergy & Immunol, New York, NY 10029 USA 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA
Web of Science 分类: Integrative & Complementary Medicine 学科类别: Integrative & Complementary Medicine
IDS 号: 786KA
ISSN: 1672-0415
29 字符的来源出版物名称缩写: CHIN J INTEGR MED
ISO 来源出版物缩写: Chin. J. Integr. Med. 来源出版物页码计数: 9 基金资助致谢: 基金资助机构 授权号
NIH/NCCAM center P01 AT002647-01 01
This work was partially supported by NIH/NCCAM center grants # P01 AT002647-01 01 "Center
for Chinese Herbal Therapy (CHT) for Asthma" to Dr. LI Xiu-min. We thank Drs. Hugh Sampson,
Ming Chun Wen, Kayer Kattan, Juan Wisnivesky, Tengfei Zhang, Kamal Srivastava, Sangita Patil,
Nan Yan, Joseph Goldfarb, Sylvan Wallenstein and Brian Schofield for their critical contribution to
ASHMI studies.
第 41 条,共 86 条 标题: Mesenchymal-stem-cell-based experimental and clinical trials: current status and open
questions 作者: Wang, J (Wang, Jin); Liao, LM (Liao, Lianming); Tan, JM (Tan, Jianming) 来源出版物 : EXPERT OPINION ON BIOLOGICAL THERAPY 卷 : 11 期 : 7 页 :
893-909 DOI: 10.1517/14712598.2011.574119 出版年: JUL 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 174 摘要: Introduction: Mesenchymal stem cells (MSCs) possess remarkable self-renewal ability and
are able to differentiate into various cell lineages. MSCs can also enhance tissue repair and
angiogenesis through a paracrine mechanism. It has been recognized that these cells hold great
promise for tissue regeneration and treatment of immune-related diseases.
Areas covered: This review aims at discussing the mechanisms of MSC-mediated
immunomodulation and tissue repair and the related clinical trials, with special emphasis on
factors that influence the efficiency of MSC-based therapy, including the source of MSCs, cell
passage, cell dose, timing and route of administration.
Expert opinion: MSCs may facilitate tissue repair through cell replacement and/or improving the
microenvironment by releasing growth factors. Some of these factors also mediate the
immunomodulatory effects of MSCs. It is important to establish global guidelines, protocols and
standards for production and clinical trials of MSCs, so that MSCs can become a therapeutic agent
with a reliable efficacy and good safety. 入藏号: WOS:000291223100006
语种: English 文献类型: Review 作者关键词: cell differentiation; cell therapy; clinical trial; mesenchymal stem cells
KeyWords Plus: MARROW STROMAL CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS;
ACUTE MYOCARDIAL-INFARCTION; HUMAN ADIPOSE-TISSUE;
VERSUS-HOST-DISEASE; ACUTE-RENAL-FAILURE; REGULATORY T-CELLS; HUMAN
UMBILICAL-CORD; IMMUNOSUPPRESSIVE DRUG-INTERACTIONS;
ARTICULAR-CARTILAGE DEFECTS 地址: [Wang, Jin; Tan, Jianming] Xiamen Univ, Fuzhou Gen Hosp, Organ Transplant Inst,
Fuzhou, Peoples R China
[Liao, Lianming] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Peoples R
China 通讯作者地址: Tan, JM (通讯作者),Xiamen Univ, Fuzhou Gen Hosp, Organ Transplant Inst,
Fuzhou, Peoples R China 电子邮件地址: [email protected] 出版商: INFORMA HEALTHCARE 出版商地址: TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
Web of Science 分类 : Biotechnology & Applied Microbiology; Medicine, Research &
Experimental 学科类别: Biotechnology & Applied Microbiology; Research & Experimental Medicine
IDS 号: 772GU
ISSN: 1471-2598
29 字符的来源出版物名称缩写: EXPERT OPIN BIOL TH
ISO 来源出版物缩写: Expert Opin. Biol. Ther. 来源出版物页码计数: 17 基金资助致谢: 基金资助机构 授权号
Natural Science Foundation of Fujian Province 2009Y4001
2008J1006
Fujian Provincial Natural Science Fund 2006J0106
Developmental Fund of Chen Keji Integrative Medicine CKJ2010021
This study was supported by the Major Program of Natural Science Foundation of Fujian Province
(2009Y4001 and 2008J1006), the Fujian Provincial Natural Science Fund (No. 2006J0106) and
the Developmental Fund of Chen Keji Integrative Medicine (No:CKJ2010021).
第 42 条,共 86 条 标题: Mechanisms of inhibition of elemene on human lens epithelial cell proliferation in vitro
作者: Hu, YH (Hu, Yan-Hong); Huang, XR (Huang, Xiu-Rong); Qi, MX (Qi, Ming-Xin); Hou,
BY (Hou, Bu-Yuan) 来源出版物 : INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 卷 : 4 期 : 3 页 :
255-258 DOI: 10.3980/j.issn.2222-3959.2011.03.08 出版年: JUN 18 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 13 摘要: AIM: To study the effects of elemene (Ele) on proliferation and cell cycle of human lens
epithelial cells 63 (HLE-B3) and the mechanisms of its signal transduction.
METHODS: Recombinant human basic fibroblast growth factor (rhbFGF) was used to induce
proliferation of HLE-B3 cells, which were incubated with 80mg/L Ele for 24 hours. The inhibitory
effects of Ele on the proliferation of HLE-B3 cells were evaluated by MU method. The effect of
Ele on HLE-B3 cell cycle was analyzed by flow cytometry (FCM). The expressions of protein
kinase A (PKA) and protein kinase G (PKG) of HLE-B3 were also analyzed by FCM.
RESULTS: Ele altered the cell cycle of HLE-B3 and effectively inhibited HLE-B3 cell
proliferation induced by rhbFGF. Ele up-regulated PKA and down-regulated the expression of
PKG in HLE-B3 cell.
CONCLUSION: Ele inhibits HLE-B3 proliferation, making it an attractive potential agent in
regimens to treat after-cataracts. 入藏号: WOS:000291921300008 语种: English 文献类型: Article 作者关键词: lens epithelial cell; cell culture; after-cataract; elemene
KeyWords Plus: BETA-ELEMENE; APOPTOSIS 地址: [Huang, Xiu-Rong; Hou, Bu-Yuan] Fujian Coll Tradit Chinese Med, Res Ctr Pathophysiol,
Fuzhou 350003, Fujian Province, Peoples R China
[Hu, Yan-Hong; Qi, Ming-Xin] Fujian Coll Tradit Chinese Med, Affiliated Peoples Hosp 2, Dept
Ophthalmol, Fuzhou 350003, Fujian Province, Peoples R China 通讯作者地址: Huang, XR (通讯作者),Fujian Coll Tradit Chinese Med, Res Ctr Pathophysiol,
Fuzhou 350003, Fujian Province, Peoples R China 电子邮件地址: [email protected] 出版商: IJO PRESS 出版商地址: NO 269 YOUYI EAST RD, XI AN, 710054, PEOPLES R CHINA
Web of Science 分类: Ophthalmology 学科类别: Ophthalmology
IDS 号: 781HK
ISSN: 1672-5123
29 字符的来源出版物名称缩写: INT J OPHTHALMOL-CHI
ISO 来源出版物缩写: Int. J. Ophthalmol. 来源出版物页码计数: 4
基金资助致谢: 基金资助机构 授权号
Youth Foundation of Fujian Scientific Committee, China 2008F3050
Youth Foundation of Fujian Scientific Committee, China (No.2008F3050)
第 43 条,共 86 条 标题: Experimental Study on the Suppression of Sodium Nitroprussiate-Induced Chondrocyte
Apoptosis by Tougu Xiaotong Capsule ((sic))-Containing Serum 作者: Li, XH (Li Xi-hai); Wu, MX (Wu Ming-xia); Ye, HZ (Ye Hong-zhi); Chen, WL (Chen
Wen-lie); Lin, JM (Lin Jiu-mao); Zheng, LP (Zheng Liang-pu); Liu, XX (Liu Xian-xiang) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 6 页 :
436-443 DOI: 10.1007/s11655-0751-x 出版年: JUN 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 1 引用的参考文献数: 22 摘要: Objective: To study the mechanism of action of Tougu Xiaotong Capsule ((sic), TGXTC) ex
vivo in suppressing chondrocyte (CD) apoptosis induced by sodium nitroprussiate (SNP).
Methods: Thirty New Zealand rabbits, 2 months old, were randomized by lottery into five groups,
six in each: the blank group treated with saline, the positive control group treated with Zhuanggu
Guanjie Pill ((sic) 70 mg/kg), and the three experimental groups, EGA, EGB, and EGC, treated
with low dose (35 mg/kg), moderate dose (70 mg/kg), and high dose (140 mg/kg) of TGXTC,
respectively. All treatments were administered via gastrogavage twice a day for 3 days. Arterial
blood was collected from the abdominal aorta and drug or drug metabolites-containing serum was
prepared. CDs obtained from knee joints of 16 four-week-old New Zealand rabbits were cultured
to the third passage and confirmed by toluidine blue staining. SNP of various final concentrations
(0, 0.5, 1.0, and 2.0 mmol/L) was used to induce CD apoptosis, and the dosage-effect relationship
of SNP in inducing CD apoptosis was determined. Serum samples from the blank, control, and
three dosages of TGXTC-treated rabbits were tested in the CD culture in the presence of SNP. Cell
apoptosis was determined by Hoechst 33342 staining, viability of CDs was quantified by MTT,
CD apoptosis rate was determined by annexin V-FITC/PI staining, levels of p53 and Bcl-2 mRNA
expression in CDs were determined with RT-PCR, and contents of caspase-3 and caspase-9
proteins were determined by colorimetry. Results: CD apoptosis was induced by SNP at all
concentrations tested and in a dose-dependent manner. The SNP concentration of 1 mmol/L and
treatment duration of 24 h appeared to be optimal and were selected for the study. Serum samples
from the positive control rabbits and from the two higher doses of TGXTC-treated rabbits showed
reduction of SNP-induced CD apoptosis, decrease in p53 mRNA expression, inhibition of catalytic
activities of caspase-3 and caspase-9, and increase in Bcl-2 mRNA expression when compared
with the serum from the blank group (P<0.05). Conclusion: TGXTC-containing sera antagonized
SNP-induced CD apoptosis and the molecular basis for the action was associated with
up-regulation of Bcl-2, down-regulation of p53 expression, and inhibition of caspase-3 and
caspase-9 catalytic activities. 入藏号: WOS:000291406000006 语种: English 文献类型: Article 作者关键词: osteoarthritis; drug-containing serum; chondrocyte; cell apoptosis; Tougu Xiaotong
Capsule
KeyWords Plus: COMPUTATIONAL PHARMACOLOGY; OSTEOARTHRITIS; GRANULE 地址: [Li Xi-hai; Wu Ming-xia; Ye Hong-zhi; Liu Xian-xiang] Fujian Univ Tradit Chinese Med,
Acad Integrat Med, Fuzhou 350108, Peoples R China
[Chen Wen-lie; Lin Jiu-mao; Zheng Liang-pu] Fujian Prov Key Lab Integrat Med Study Senile
Dis, Fuzhou 350108, Peoples R China 通讯作者地址: Wu, MX (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med,
Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA
Web of Science 分类: Integrative & Complementary Medicine 学科类别: Integrative & Complementary Medicine
IDS 号: 774SG
ISSN: 1672-0415
29 字符的来源出版物名称缩写: CHIN J INTEGR MED
ISO 来源出版物缩写: Chin. J. Integr. Med. 来源出版物页码计数: 8 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China 81072826
Major Project Foundation of Fujian Provincial Administration of Science and
Technology 2009Y0029
Developmental Fund of CHEN Keji Integrative Medicine CKJ2010013
Supported by the National Natural Science Foundation of China (No. 81072826), Major Project
Foundation of Fujian Provincial Administration of Science and Technology (No. 2009Y0029), and
the Developmental Fund of CHEN Keji Integrative Medicine (No. CKJ2010013)
第 44 条,共 86 条 标题: (S)-Benzyl 3-(4-hydroxyphenyl)-2-(tritylamino)propanoate 作者: Chen, MM (Chen, Meimei); Lai, XM (Lai, Xinmei); Zhou, CG (Zhou, Changen); Yang, XM
(Yang, Xuemei)
来源 出版物 : ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS
ONLINE 卷: 67 页: O1412-U678 DOI: 10.1107/S1600536811017351 子辑: Part 6 出版年:
JUN 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 5 摘要 : The title compound, C(35)H(31)NO(3), was obtained by the reaction of (S)-benzyl
2-amino-3-(4-hydroxyphenyl)propanoate and (chloromethanetriyl)tribenzene. The enantiomer has
been assigned by reference to an unchanging chiral centre in the synthetic procedure. In the
crystal, molecules are linked into chains running along the a axis by intermolecular O-H...O
hydrogen bonds. 入藏号: WOS:000291216100056 语种: English 文献类型: Article 地址: [Chen, Meimei; Lai, Xinmei; Zhou, Changen; Yang, Xuemei] Fujian Univ Tradit Chinese
Med, Coll Tradit Chinese Med, Fujian 350108, Peoples R China 通讯作者地址: Yang, XM (通讯作者),Fujian Univ Tradit Chinese Med, Coll Tradit Chinese Med,
Fujian 350108, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Web of Science 分类: Crystallography 学科类别: Crystallography
IDS 号: 772EL
ISSN: 1600-5368
29 字符的来源出版物名称缩写: ACTA CRYSTALLOGR E
ISO 来源出版物缩写: Acta Crystallogr. Sect. E.-Struct Rep. Online 来源出版物页码计数: 11 基金资助致谢: 基金资助机构 授权号
Fujian Provincial Department of Education JA09130
Fujian Provincial Health Department wzzsj0901
We gratefully acknowledge financial support by the Fujian Provincial Department of Education
project (JA09130) and the Fujian Provincial Health Department Special Project (wzzsj0901).
第 45 条,共 86 条 标题: Antifatigue Activity of the Liposoluble Fraction from Acanthopanax senticosus
作者: Huang, LZ (Huang, Lin-Zhang); Huang, BK (Huang, Bao-Kang); Liang, J (Liang, Jie);
Zheng, CJ (Zheng, Cheng-Jian); Han, T (Han, Ting); Zhang, QY (Zhang, Qiao-Yan); Qin, LP
(Qin, Lu-Ping) 来 源 出 版 物 : PHYTOTHERAPY RESEARCH 卷 : 25 期 : 6 页 : 940-943 DOI:
10.1002/ptr.3346 出版年: JUN 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 10 摘要: The crude extract of Acanthopanax senticosus (AS) has been used extensively in Russia,
China, Korea and Japan as an adaptogenic agent to fight against stress and fatigue. However,
whether the liposoluble fraction possesses antifatigue activity or not is still unclear. A liposoluble
fraction was administered orally to mice for 9 days. The swimming time to exhaustion was longer
in the treatment groups (22.2 +/- 3.3, 25.5 +/- 4.8 min) than in the control group (13.7 +/- 1.2 min,
p < 0.05). The plasma TG (triglyceride) and BUN (blood urea nitrogen) levels in the high dose
(500 mg/kg) groups were decreased significantly compared with the control group. Plasma lactate
dehydrogenase (LDH) was lower in the treatment groups than in the control group. Chemical
analysis from GC/MS revealed that the main components of the liposoluble fraction of AS were
saturated fatty acid (12.98%), unsaturated fatty acid (33.13%), unsaturated alcohol (27.46%) and
diolefine (15.76%). In conclusion, the liposoluble fraction enhanced the forced swimming
capacity of mice by decreasing muscle damage, effectively preventing the increase in BUN
concentration and increasing fat utilization. It is proposed that the antioxidant effect may be one of
the antifatigue mechanisms of the liposoluble fraction of AS. Copyright (C) 2010 John Wiley &
Sons, Ltd. 入藏号: WOS:000291060700025 语种: English 文献类型: Article 作者关键词: swimming time; exhaustion; TG; BUN; LDH; GC/MS; antioxidant
KeyWords Plus: ELEUTHEROCOCCUS-SENTICOSUS; EXERCISE; MICE 地址: [Huang, Lin-Zhang; Huang, Bao-Kang; Liang, Jie; Zheng, Cheng-Jian; Han, Ting; Zhang,
Qiao-Yan; Qin, Lu-Ping] Mil Med Coll 2, Dept Pharmacognosy, Sch Pharm, Shanghai 200433,
Peoples R China
[Huang, Lin-Zhang; Liang, Jie] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108,
Peoples R China 通讯作者地址: Qin, LP (通讯作者),Mil Med Coll 2, Dept Pharmacognosy, Sch Pharm, 325
Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Web of Science 分类: Chemistry, Medicinal; Pharmacology & Pharmacy 学科类别: Pharmacology & Pharmacy
IDS 号: 770AZ
ISSN: 0951-418X
29 字符的来源出版物名称缩写: PHYTOTHER RES
ISO 来源出版物缩写: Phytother. Res. 来源出版物页码计数: 4
第 46 条,共 86 条 标题: Chemical constituents from Salacia amplifolia 作者: Wang, Y (Wang, Yan); Chen, WS (Chen, Wan-Sheng); Wu, ZJ (Wu, Zhi-Jun); Xi, ZX (Xi,
Zhong-Xin); Chen, W (Chen, Wei); Zhao, GJ (Zhao, Gui-Jun); Li, X (Li, Xia); Sun, LN (Sun,
Lian-Na) 来源出版物 : BIOCHEMICAL SYSTEMATICS AND ECOLOGY 卷 : 39 期 : 3 页 :
205-208 DOI: 10.1016/j.bse.2011.03.001 出版年: JUN 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 34 摘要: The present phytochemical investigation on Salacia amplifolia led to the isolations of 13
triterpenes, including quinonemethides, friedelanes, oleananes and ursanes triterpenes, three
simple phenolics, one polyol and one chromanone. All of them were isolated from this plant for
the first time. The presences of quinonemethide triterpenoids might be employed as the common
characteristic constituents of both Hippocrateaceae and Celastraceae families. (C) 2011 Elsevier
Ltd. All rights reserved. 入藏号: WOS:000291902900007 语种: English 文献类型: Article 作者关键词: Salacia amplifolia; Triterpenes; Hippocrateaceae; Quinonemethides
KeyWords Plus: TRITERPENOID CONSTITUENTS; TRIPTERYGIUM-WILFORDII;
ASSIGNMENTS; TERPENOIDS; INHIBITORS 地址: [Wang, Yan; Xi, Zhong-Xin; Chen, Wei; Sun, Lian-Na] Mil Med Coll 2, Sch Pharm, Dept
Pharmacognosy, Shanghai 200433, Peoples R China
[Chen, Wan-Sheng; Wu, Zhi-Jun; Zhao, Gui-Jun; Li, Xia] Mil Med Coll 2, Shanghai Changzheng
Hosp, Dept Pharm, Shanghai 200003, Peoples R China
[Wang, Yan; Xi, Zhong-Xin] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108,
Fujian, Peoples R China 通讯作者地址: Sun, LN (通讯作者),Mil Med Coll 2, Sch Pharm, Dept Pharmacognosy, 325
Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected] 出版商: PERGAMON-ELSEVIER SCIENCE LTD 出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,
ENGLAND
Web of Science 分类: Biochemistry & Molecular Biology; Ecology; Evolutionary Biology
学科类别: Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary
Biology
IDS 号: 781AL
ISSN: 0305-1978
29 字符的来源出版物名称缩写: BIOCHEM SYST ECOL
ISO 来源出版物缩写: Biochem. Syst. Ecol. 来源出版物页码计数: 4 基金资助致谢: 基金资助机构 授权号
Shanghai Science and Technology Commission 08DZ1971503
This work was supported by the Program of Shanghai Science and Technology Commission
(08DZ1971503).
第 47 条,共 86 条 标题: Scutellaria barbata D. Don induces apoptosis of human colon carcinoma cell through
activation of the mitochondrion-dependent pathway 作者: Wei, LH (Wei, Lihui); Chen, YQ (Chen, Youqin); Lin, JM (Lin, Jiumao); Zhao, JY (Zhao,
Jinyan); Chen, XZ (Chen, Xuzheng); Xu, W (Xu, Wei); Liu, XX (Liu, Xianxiang); Sferra, TJ
(Sferra, Thomas J.); Peng, J (Peng, Jun) 来源出版物 : JOURNAL OF MEDICINAL PLANTS RESEARCH 卷 : 5 期 : 10 页 :
1962-1970 出版年: MAY 18 2011 在 Web of Science 中的被引频次: 3 被引频次合计: 3 引用的参考文献数: 30 摘要: Scutellaria barbata D. Don has long been used in China for the clinical treatment of various
cancers including colorectal cancer. However, the precise mechanisms of its tumorcidal activity
remain unclear. In the present study, we investigated the cellular effects of the ethanol extract of S.
barbata D. Don (EESB) in the HT-29 human colon carcinoma cell line. We found that EESB
inhibited the growth of HT-29 cells as demonstrated EESB-induced cell morphological changes
and reduced cell viability in dose-and time-dependent manners. Furthermore, we observed that
EESB treatment resulted in DNA fragmentation, loss of plasma membrane asymmetry, collapse of
mitochondrial membrane potential, activation of caspase-9 and caspase-3, and increase of the ratio
of pro-apoptotic Bax to anti-apoptotic Bcl-2. These results suggest that promotion of cancer cell
apoptosis through activation of the mitochondrion-dependent pathway is one of the mechanisms
by which S. barbata D. Don can be effective in the treatment of cancer. 入藏号: WOS:000297456800019 语种: English 文献类型: Article
作者关键词: Scutellaria barbata D. Don; apoptosis; colorectal cancer; HT-29 cells; herbal
medicine; mitochondria
KeyWords Plus: CHANNEL-FORMING ACTIVITY; CYTOCHROME-C;
COLORECTAL-CANCER; DRUG-RESISTANCE; LEUKEMIA-CELLS; BCL-2; BAX;
RELEASE; FAMILY; CHEMOPREVENTION 地址: [Wei, Lihui; Lin, Jiumao; Zhao, Jinyan; Chen, Xuzheng; Liu, Xianxiang; Peng, Jun] Fujian
Univ Tradit Chinese Med, Fujian Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China
[Chen, Youqin; Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK
73190 USA
[Xu, Wei] Fujian Univ Tradit Chinese Med, Dept Pharmacol, Fuzhou 350108, Fujian, Peoples R
China
[Chen, Youqin; Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol,
Oklahoma City, OK 73190 USA 通讯作者地址: Peng, J (通讯作者),Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med, 1
Huatuo Rd, Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
Web of Science 分类: Chemistry, Medicinal 学科类别: Pharmacology & Pharmacy
IDS 号: 853WQ
ISSN: 1996-0875
29 字符的来源出版物名称缩写: J MED PLANTS RES
ISO 来源出版物缩写: J. Med. Plants Res. 来源出版物页码计数: 9 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China 81073097
Natural Science Foundation of Fujian Province of China 2010J01195
Developmental Fund of Chen Keji Integrative Medicine CKJ 2010019
Fujian Key Laboratory of Integrative Medicine on Geriatrics 2008J1004
This work was sponsored by the National Natural Science Foundation of China (81073097), the
Natural Science Foundation of Fujian Province of China (2010J01195), the Developmental Fund
of Chen Keji Integrative Medicine (CKJ 2010019), and the Open Fund of Fujian Key Laboratory
of Integrative Medicine on Geriatrics (2008J1004).
第 48 条,共 86 条
标题: The effect of Eleutheroside E on behavioral alterations in murine sleep deprivation stress
model 作者: Huang, LZ (Huang, Lin-Zhang); Wei, L (Wei, Lei); Zhao, HF (Zhao, Hong-Fang); Huang,
BK (Huang, Bao-Kang); Rahman, K (Rahman, Khalid); Qin, LP (Qin, Lu-Ping) 来源出版物 : EUROPEAN JOURNAL OF PHARMACOLOGY 卷 : 658 期 : 2-3 页 :
150-155 DOI: 10.1016/j.ejphar.2011.02.036 出版年: MAY 11 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 1 摘要: Eleutheroside E (EE), a principal component of Eleutherococcus senticosus, has been
reported to have anti-inflammatory and protective effects in ischemia heart etc. However, whether
it can mitigate behavioral alterations induced by sleep deprivation, has not yet been elucidated.
Numerous studies have demonstrated that memory deficits induced by sleep deprivation in
experimental animals can be used as a model of behavioral alterations. The present study
investigated the effect of EE, on cognitive performances and biochemical parameters of
sleep-deprived mice. Animals were repeatedly treated with saline, 10 or 50 mg/kg EE and
sleep-deprived for 72 h by the multiple platform method. Briefly, groups of 5-6 mice were placed
in water tanks (45 x 34 x 17 cm), containing 12 platforms (3 cm in diameter) each, surrounded by
water up to 1 cm beneath the surface or kept in their home cage. After sleep deprivation, mice
showed significant behavioral impairment as evident by reduced latency entering into a dark
chamber, locomotion and correctly rate in Y maze, and increased monoamines in hippocampus.
However, repeated treatment with EE restored these behavioral and biochemical alterations in
mice. In conclusion, the beneficial effect of EE may provide an effective and powerful strategy to
alleviate behavioral alterations induced by sleep deprivation. (C) 2011 Elsevier B.V. All rights
reserved. 入藏号: WOS:000290010500014 语种: English 文献类型: Article 作者关键词: Eleutheroside E; Behavioral alteration; Locomotor; Passive avoidance; Y maze 地址: [Huang, Lin-Zhang; Zhao, Hong-Fang; Huang, Bao-Kang; Qin, Lu-Ping] Mil Med Coll 2,
Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China
[Huang, Lin-Zhang; Zhao, Hong-Fang] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou
350108, Peoples R China
[Wei, Lei] Mil Med Coll 2, Changhai Hosp, Dept Internal Med, Div Field Med, Shanghai 200433,
Peoples R China
[Rahman, Khalid] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Liverpool L3 3AF,
Merseyside, England 通讯作者地址: Qin, LP (通讯作者),Mil Med Coll 2, Sch Pharm, Dept Pharmacognosy, 325
Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected] 出版商: ELSEVIER SCIENCE BV
出版商地址: PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Web of Science 分类: Pharmacology & Pharmacy 学科类别: Pharmacology & Pharmacy
IDS 号: 756KQ
ISSN: 0014-2999
29 字符的来源出版物名称缩写: EUR J PHARMACOL
ISO 来源出版物缩写: Eur. J. Pharmacol. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
military medical and health research fund project 08Z022
This work was supported by a special grant from the military medical and health research fund
project (No. 08Z022).
第 49 条,共 86 条 标题: Developments in Microfluidics-based Immunoassays 作者: Chen, ZN (Chen Zhao-Na); Liu, BH (Liu Bao-Hong); Wu, HL (Wu Hui-Ling); Yang, PY
(Yang Peng-Yuan) 来源出版物: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 卷: 32 期:
5 页: 1001-1007 出版年: MAY 10 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 57 摘要: Microfluidics-based immunoassays have become an increasing research field in recent years
owing to their advantages of miniaturization, high throughput, fast detection and low
consumption. Detection is an important part in microfluidics-based immunoassays. Recent
advances in the studies of micro-systems and detection methods, including electrochemical
detection., fluorescence spectrometry, ultraviolet-visible spectrometry, chemiluminescence and
bioluminescence, surface-enhanced Raman scattering, fiber-optic sensor, surface plasmon
resonance, thermal lens microscopy, colorimetry and other new detection methods applied in
microfluidics-based immunoassays, were summarized and reviewed in this paper. The prospects
of the detection methods for microfluidics-based immunoassays were presented. 入藏号: WOS:000291175800001 语种: Chinese 文献类型: Review 作者关键词: Microfluidics; Immunoassays; Detection method
KeyWords Plus: ENHANCED RAMAN-SCATTERING; ENZYME-IMMUNOASSAY; RAPID
DETECTION; CHIP; MICROCHIP; SYSTEM; SURFACE; REACTOR; IMMUNOSENSOR;
PROTEOLYSIS 地址: [Chen Zhao-Na; Liu Bao-Hong; Yang Peng-Yuan] Fudan Univ, Inst Biomed Sci, Dept
Chem, Shanghai 200433, Peoples R China
[Chen Zhao-Na] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108, Peoples R China
[Chen Zhao-Na; Wu Hui-Ling] Mil Med Coll 2, Sch Pharm, Shanghai 200433, Peoples R China 通讯作者地址: Yang, PY (通讯作者),Fudan Univ, Inst Biomed Sci, Dept Chem, Shanghai
200433, Peoples R China 电子邮件地址: [email protected] 出版商: HIGHER EDUCATION PRESS 出版商地址: SHATANHOU ST 55, BEIJING 100009, PEOPLES R CHINA
Web of Science 分类: Chemistry, Multidisciplinary 学科类别: Chemistry
IDS 号: 771QM
ISSN: 0251-0790
29 字符的来源出版物名称缩写: CHEM J CHINESE U
ISO 来源出版物缩写: Chem. J. Chin. Univ.-Chin. 来源出版物页码计数: 7
第 50 条,共 86 条 标题: The use of sodium trimetaphosphate as a biomimetic analog of matrix phosphoproteins for
remineralization of artificial caries-like dentin 作者: Liu, Y (Liu, Yan); Li, N (Li, Nan); Qi, YP (Qi, Yipin); Niu, LN (Niu, Li-na); Elshafiy, S
(Elshafiy, Sally); Mao, J (Mao, Jing); Breschi, L (Breschi, Lorenzo); Pashley, DH (Pashley, David
H.); Tay, FR (Tay, Franklin R.) 来 源 出 版 物 : DENTAL MATERIALS 卷 : 27 期 : 5 页 : 465-477 DOI:
10.1016/j.dental.2011.01.008 出版年: MAY 2011 在 Web of Science 中的被引频次: 2 被引频次合计: 2 引用的参考文献数: 62 摘要: Objectives. This study examined the use of sodium trimetaphosphate (STMP) as a
biomimetic analog of matrix phosphoproteins for remineralization of artificial carious-affected
dentin.
Methods. Artificial carious lesions with lesion depths of 300 +/- 30 mu m were created by
pH-cycling. 2.5% hydrolyzed STMP was applied to the artificial carious lesions to phosphorylate
the partially-demineralized collagen matrix. Half of the STMP-treated specimens were bonded
with One-Step. The adhesive and non-adhesive infiltrated specimens were remineralized in a
Portland cement-simulated body fluid system containing polyacrylic acid (PAA) to stabilize
amorphous calcium phosphate as nanoprecursors. Micro-computed tomography (micro-CT) and
transmission electron microscopy (TEM) were used to evaluate the results of remineralization
after a 4-month period.
Results. In absence of PAA and STMP as biomimetic analogs (control groups), there was no
remineralization irrespective of whether the lesions were infiltrated with adhesive. For the
STMP-treated experimental groups immersed in PAA-containing simulated body fluid, specimens
without adhesive infiltration were more heavily remineralized than those infiltrated with adhesive.
Statistical analysis of the 4-month micro-CT data revealed significant differences in the lesion
depth, relative mineral content along the lesion surface and changes in Delta Z between the
non-adhesive and adhesive experimental groups (p < 0.05 for all the three parameters). TEM
examination indicated that collagen degradation occurred in both the non-adhesive and adhesive
control and experimental groups after 4 months of remineralization. 入藏号: WOS:000288941300010 语种: English 文献类型: Article 作者关键词: Artificial carious lesion; Biomimetic; Collagen; Degradation; Remineralization;
Sodium trimetaphosphate
KeyWords Plus: CONFOCAL RAMAN MICROSPECTROSCOPY; IN-VITRO
REMINERALIZATION; CARIOUS DENTIN; CALCIUM-PHOSPHATE; ADHESIVE
SYSTEMS; CRYSTAL-GROWTH; BOND STRENGTH; 2 LAYERS; COLLAGEN; LESIONS 地址: [Elshafiy, Sally; Pashley, David H.; Tay, Franklin R.] Med Coll Georgia, Sch Dent, Dept
Endodont, Augusta, GA 30912 USA
[Elshafiy, Sally; Pashley, David H.; Tay, Franklin R.] Med Coll Georgia, Sch Dent, Dept Oral
Biol, Augusta, GA 30912 USA
[Liu, Yan; Mao, Jing] Huazhong Univ Sci & Technol, Dept Stomatol, Tongji Hosp, Tongji Med
Coll, Wuhan 430074, Peoples R China
[Li, Nan] Fujian Univ Tradit Chinese Med, Dept Osteoped & Traumatol, Fuzhou, Fujian, Peoples
R China
[Qi, Yipin] Sun Yat Sen Univ, Dept Operat Dent & Endodont, Guanghua Sch Stomatol,
Guangzhou 510275, Guangdong, Peoples R China
[Niu, Li-na] Fourth Mil Med Univ, Dept Prosthodont, Sch Stomatol, Xian 710032, Peoples R
China
[Breschi, Lorenzo] Univ Trieste, Dept Biomed, Trieste, Italy
[Breschi, Lorenzo] IOR, IGM CNR, Unit Bologna, Bologna, Italy 通讯作者地址: Tay, FR (通讯作者),Med Coll Georgia, Sch Dent, Dept Endodont, Augusta, GA
30912 USA 电子邮件地址: [email protected] 出版商: ELSEVIER SCI LTD 出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,
OXON, ENGLAND
Web of Science 分类: Dentistry, Oral Surgery & Medicine; Materials Science, Biomaterials 学科类别: Dentistry, Oral Surgery & Medicine; Materials Science
IDS 号: 742KL
ISSN: 0109-5641
29 字符的来源出版物名称缩写: DENT MATER
ISO 来源出版物缩写: Dent. Mater. 来源出版物页码计数: 13 基金资助致谢: 基金资助机构 授权号
NIDCR R21 DE019213
Medical College of Georgia
This work was supported by grant R21 DE019213 from NIDCR (PI. Franklin Tay) and the PSRP
award from the Medical College of Georgia.
窗体顶端
Web of Knowledge 第 2 页 (文章 51 -- 86)
[ 1 | 2 ]
第 51 条,共 86 条 标题: Inhibitory effect of polysaccharides isolated from Angelica sinensis on hepcidin expression 作者: Wang, KP (Wang, Kai-Ping); Zeng, F (Zeng, Fang); Liu, JY (Liu, Jin-Yu); Guo, D (Guo,
Dan); Zhang, Y (Zhang, Yu)
来源出版物: JOURNAL OF ETHNOPHARMACOLOGY 卷: 134 期: 3 页: 944-948 DOI:
10.1016/j.jep.2011.02.015 出版年: APR 12 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 21 摘要 : Ethnopharmacological relevance: Angelica sinensis polysaccharide is an important
bioactive component of Angelica sinensis (Oliv.) Diels that has been used in traditional Chinese
medicine for treating gynecological disorders and anemia.
Aim of the study: Previous study indicated that Angelica sinensis polysaccharide (ASP) may
promote plasma iron levels by suppressing the expression of hepcidin, a negative regulator of
body iron metabolism, in the liver. The present study aims to clarify the inhibitory effect of ASP
on hepcidin expression as well as the involved mechanisms.
Materials and Methods: ASP (1 g/kg) or vehicle (normal saline) was intragastrically administrated
to rats everyday for 14d. Intraperitoneal injections of recombinant human erythropoietin (rhEPO,
2000 U/kg) were given to positive control group. Erythropoietin and hepcidin levels in serum at
different time points were determined by enzyme-linked immunosorbent assay. Western blot was
used to investigate the expression of 6 pertinent signal proteins in liver.
Results: ASP significantly reduced hepcidin expression by inhibiting the expression of signal
transducer and activator of transcription 3/5 (STAT3/5) and mothers against decapentaplegic
protein 4 (SMAD4) in liver and stimulating the secretion of erythropoietin, which further
down-regulated hepcidin by repressing CCAAT/enhancer-binding protein a (C/EBP alpha).
SMAD4, and the phosphorylation process of STAT3/5.
Conclusions: ASP can suppress the expression of hepcidin in normal rats, and may be used in the
treatments of hepcidin-induced diseases. (C) 2011 Elsevier Ireland Ltd. All rights reserved. 入藏号: WOS:000289866500046 语种: English 文献类型: Article 作者关键词 : Angelica sinensis; Polysaccharides; Erythropoietin; Hepcidin; Iron deficiency
diseases
KeyWords Plus: IRON-DEFICIENCY; C/EBP-ALPHA; ANEMIA; METABOLISM; PEPTIDE;
SMAD4 地址: [Zhang, Yu] Huazhong Univ Sci & Technol, Dept Pharm, Union Hosp, Wuhan 430030,
Peoples R China
[Wang, Kai-Ping; Zeng, Fang; Liu, Jin-Yu] Huazhong Univ Sci & Technol, Tongji Med Coll,
Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
[Guo, Dan] Fujian Inst Tradit Chinese Med, Fuzhou 350003, Peoples R China 通讯作者地址: Zhang, Y (通讯作者),Huazhong Univ Sci & Technol, Dept Pharm, Union Hosp,
1227 Jiefang Rd, Wuhan 430030, Peoples R China 电子邮件地址: [email protected] 出版商: ELSEVIER IRELAND LTD 出版商地址: ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO,
CLARE, 00000, IRELAND
Web of Science 分类: Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
Medicine; Pharmacology & Pharmacy 学科类别: Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine
IDS 号: 754OZ
ISSN: 0378-8741
29 字符的来源出版物名称缩写: J ETHNOPHARMACOL
ISO 来源出版物缩写: J. Ethnopharmacol. 来源出版物页码计数: 5 基金资助致谢: 基金资助机构 授权号
Nation Natural Science Foundation of China 30973910
The present study was supported by grants from the Nation Natural Science Foundation of China
(Grant No. 30973910).
第 52 条,共 86 条 标题: Antitussive Activity of Pseudostellaria heterophylla (Miq.) Pax Extracts and Improvement
in Lung Function via Adjustment of Multi-Cytokine Levels 作者: Pang, WS (Pang, Wensheng); Lin, SD (Lin, Siding); Dai, QW (Dai, Qiwen); Zhang, HC
(Zhang, Hongcheng); Hu, J (Hu, Juan) 来源出版物: MOLECULES 卷: 16 期: 4 页: 3360-3370 DOI: 10.3390/molecules16043360 出版年: APR 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 28 摘要: Pseudostellaria heterophylla (Miq.) Pax is one of the most widespread herbal and healthcare
products in China. Extensive clinical use has shown that it has functions which "strengthens qi and
generates saliva, moistens the lung and relieves cough". The ethyl acetate fraction extracted from
the roots of the plant Pseudostellaria heterophylla exhibited a dose-dependent antitussive effect
between 100 to 500 mg/kg. At a dose of 400 mg/kg, the ethyl acetate fraction treatment markedly
prolonged the cough latent period and reduced the number of coughs in a guinea pig model
induced by citric acid. Fall lung airway resistance, rise in dynamic lung compliance, decreased
serum levels of IL-8, GM-CSF, TNF-alpha, and ET-1 in rat model of stable phase chronic
obstructive pulmonary disease induced by cigarette smoke exposure were also observed. These
results suggest that ethyl acetate fraction has antitussive activity related to its improvement in lung
function via attenuation of airway inflammation by adjustment of multi-cytokine levels. 入藏号: WOS:000289976200023 语种: English
文献类型: Article 作者关键词: Pseudostellaria heterophylla (Miq.) Pax; extracts; antitussive activity; improvement
lung function; multi-cytokine adjusting
KeyWords Plus: STEMONA-TUBEROSA; GENE-EXPRESSION; COPD; MACROPHAGES 地址: [Pang, Wensheng; Lin, Siding; Dai, Qiwen; Zhang, Hongcheng; Hu, Juan] Fujian Univ
Tradit Chinese Med, Sch Pharm, Fuzhou 350108, Peoples R China 通讯作者地址: Hu, J (通讯作者),Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350108,
Peoples R China 电 子 邮 件 地 址 : [email protected]; [email protected]; [email protected];
[email protected]; [email protected] 出版商: MDPI AG 出版商地址: KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND
Web of Science 分类: Chemistry, Organic 学科类别: Chemistry
IDS 号: 755YE
ISSN: 1420-3049
29 字符的来源出版物名称缩写: MOLECULES
ISO 来源出版物缩写: Molecules 来源出版物页码计数: 11 基金资助致谢: 基金资助机构 授权号
Foundation of Social Development
Fujian Provincial Department of Science Technology 2008Y0047
Traditional Chinese Medicine and Quality Control Engineering Technology
Research Center Platform of Fujian Province 2009Y2003
We thank Jianmin Xie from the Zhejiang University School of Medicine for his guidance. The
authors are grateful to the Foundation of Social Development, Fujian Provincial Department of
Science & Technology (2008Y0047) and the support of preclinical studies of the Traditional
Chinese Medicine and Quality Control Engineering Technology Research Center Platform of
Fujian Province (2009Y2003).
第 53 条,共 86 条 标题: Prediction of residual/recurrent disease by HPV Genotype after loop excision procedure for
high-grade cervical intraepithelial neoplasia with negative margins 作者: Wu, DM (Wu, Dongmei); Zheng, YZ (Zheng, Yizhen); Chen, W (Chen, Wei); Guo, CR
(Guo, Ciren); Yu, JA (Yu, Jiang); Chen, GL (Chen, Guilin); Huang, YL (Huang, Yanling) 来源出版物 : AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS &
GYNAECOLOGY 卷: 51 期: 2 页: 114-118 DOI: 10.1111/j.1479-828X.2010.01280.x 出版年:
APR 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 25 摘要 : Aims: This study aims to evaluate whether the preconisation of high-risk human
papillomavirus (HR-HPV) genotype and multiple HPV infection is predictive for
residual/recurrent disease during the follow-up of high-grade cervical intraepithelial neoplasia
(CIN) treated by loop electrosurgical excision procedure (LEEP) with negative margins.
Methods: Two hundred and thirty-six women (mean age 37; range 20-61) with CIN2/3 treated by
LEEP conisation with negative margins confirmed by pathology examination of the surgical
specimen were included. The cervical cells for HPV genotype testing by the polymerase chain
reaction (PCR) were collected before, and 6, 12, 24 months after treatment, respectively. HPV
genotype and multiple HPV infection were evaluated as possible predictors of residual/recurrent
disease.
Results: Residual/recurrent disease was demonstrated by colposcopy-guided biopsy in 62 patients
(26.3%) who underwent loop conisation with negative margins. Preoperative infection with either
HPV16 (P = 0.007), HPV18 (P = 0.000), HPV33 (P = 0.001) or HPV45 (P = 0.019) was associated
with higher rates of residual/recurrent lesions after conisation with negative margins. Preoperative
infection with multiple HPV types was associated with the highest rate of residual/recurrent
lesions compared with infection with single HPV type and HPV-negative cases (chi(2) = 16.599, P
< 0.001).
Conclusions: Results demonstrate that the presence of HPV-16, 18, 33 and 45, as well as multiple
HPV types pre-LEEP, is associated with higher rates of residual/recurrent disease after LEEP. 入藏号: WOS:000289248700004 语种: English 文献类型: Article 作 者 关 键 词 : cervical intraepithelial neoplasia; HPV Genotype; negative margins;
residual/recurrence
KeyWords Plus: OF-THE-LITERATURE; HUMAN-PAPILLOMAVIRUS;
ELECTROSURGICAL EXCISION; RECURRENT DISEASE; TREATMENT FAILURE;
NATURAL-HISTORY; PRE-CONIZATION; PERSISTENCE; INFECTION; CANCER 地址: [Wu, Dongmei; Zheng, Yizhen; Yu, Jiang] Fujian Univ Tradit Chinese Med, Affiliated Hosp
2, Dept Gynecol & Obstet, Fuzhou 350003, Peoples R China
[Chen, Wei; Guo, Ciren; Chen, Guilin; Huang, Yanling] Fujian Prov Tumor Hosp, Dept Gynecol,
Fuzhou, Peoples R China 通讯作者地址: Wu, DM (通讯作者),Fujian Univ Tradit Chinese Med, Affiliated Hosp 2, Dept
Gynecol & Obstet, 13 Hudongzhi Rd, Fuzhou 350003, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Web of Science 分类: Obstetrics & Gynecology 学科类别: Obstetrics & Gynecology
IDS 号: 746LQ
ISSN: 0004-8666
29 字符的来源出版物名称缩写: AUST NZ J OBSTET GYN
ISO 来源出版物缩写: Aust. N. Z. J. Obstet. Gynaecol. 来源出版物页码计数: 5 基金资助致谢: 基金资助机构 授权号
Natural Science Foundation of Fujian Province 2010J01182
This work was supported by Natural Science Foundation of Fujian Province (2010J01182).
第 54 条,共 86 条 标题: Effects of Laser Irradiation of Acupuncture Points Shenshu on Ovariectomized Rats 作者: Zhang, YS (Zhang, Yi-Shi); Xu, YX (Xu, Yun-Xiang); Chen, CS (Chen, Chang-Shui);
Chen, GZ (Chen, Gui-Zhen); Weng, ZX (Weng, Zu-Xing); Yao, Y (Yao, Yao) 来源出版物: PHOTOMEDICINE AND LASER SURGERY 卷: 29 期: 4 页: 271-275 DOI:
10.1089/pho.2010.2763 出版年: APR 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 16 摘要: Background and Objective: The effect of laser acupuncture on obesity in postmenopausal
women remains unknown. The aim of this study was to investigate the effects of this form of
treatment using an animal model. Materials and Methods: Seventy-seven female Sprague-Dawley
rats were assigned into seven groups: normal control (Normal), sham-operation control (Sham),
ovariectomized (OVX) control rats (OVX), OVX rats treated with estrogen (OVX + E), and three
groups of ovariectomized rats treated with laser acupuncture (OVX + L). Bilateral ovaries were
removed to decrease estrogen levels. After 2 wk, semiconductor laser irradiation was administered
to bilateral Shenshu (BL 23) acupoints of rats in the three OVX + L groups at 12, 30, and 60
J/cm(2), respectively. Changes in body weight and pituitary estrogen receptor (ER) mRNA
expression were analyzed. Morphological differences in the uterus and pituitary glands were also
observed. Results: The OVX group exhibited marked weight gain and a significant decrease in
pituitary ER alpha mRNA expression. Semiconductor laser irradiation at 30 J/cm(2) reduced body
weight and increased ER alpha expression compared with the control, whereas irradiation at 12 or
60 J/cm(2) presented slightly weaker effects. Significant differences in pituitary ER beta mRNA
were not observed due to lack of optical density data. Conclusions: The semiconductor laser
irradiation of bilateral Shenshu (BL 23) acupoints can exert beneficial effects on OVX rats
through reducing body weight and increasing pituitary ER alpha expression, and 30 J/cm(2) was
the most effective dose among those used.
入藏号: WOS:000289074200009 语种: English 文献类型: Article
KeyWords Plus: FEMALE RAT; SITES 地址 : [Zhang, Yi-Shi; Chen, Chang-Shui; Chen, Gui-Zhen] S China Normal Univ, Coll
Biophoton, Lab Photon Chinese Med, Guangzhou 510631, Guangdong, Peoples R China
[Xu, Yun-Xiang; Chen, Gui-Zhen] Guangzhou Univ Tradit Chinese Med, Guangzhou,
Guangdong, Peoples R China
[Weng, Zu-Xing; Yao, Yao] Fujian Coll Tradit Chinese Med, Fuzhou, Fujian, Peoples R China 通讯作者地址: Chen, GZ (通讯作者),S China Normal Univ, Coll Biophoton, Lab Photon
Chinese Med, Guangzhou 510631, Guangdong, Peoples R China 电子邮件地址: [email protected] 出版商: MARY ANN LIEBERT INC 出版商地址: 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
Web of Science 分类: Surgery 学科类别: Surgery
IDS 号: 744DK
ISSN: 1549-5418
29 字符的来源出版物名称缩写: PHOTOMED LASER SURG
ISO 来源出版物缩写: Photomed. Laser Surg. 来源出版物页码计数: 5 基金资助致谢: 基金资助机构 授权号
Post-doctoral Foundation of China 20070410242
Administration of Traditional Chinese Medicine of Guangdong Province 2007166
Guangdong Natural Science Foundation 8451063101001809
This work was supported by the Post-doctoral Foundation of China under grant No. 20070410242
and the Administration of Traditional Chinese Medicine of Guangdong Province under grant No.
2007166, and grant No. 8451063101001809 of Guangdong Natural Science Foundation.
第 55 条,共 86 条 标题: Differences between top-down and bottom-up approaches in mineralizing thick, partially
demineralized collagen scaffolds 作者: Liu, Y (Liu, Yan); Mai, S (Mai, Sui); Li, N (Li, Nan); Yiu, CKY (Yiu, Cynthia K. Y.); Mao,
J (Mao, Jing); Pashley, DH (Pashley, David H.); Tay, FR (Tay, Franklin R.) 来 源 出 版 物 : ACTA BIOMATERIALIA 卷 : 7 期 : 4 页 : 1742-1751 DOI:
10.1016/j.actbio.2010.11.028 出版年: APR 2011
在 Web of Science 中的被引频次: 3 被引频次合计: 3 引用的参考文献数: 48 摘要: Biominerals exhibit complex hierarchical structures derived from bottom-up self-assembly
mechanisms. Type I collagen serves as the building block for mineralized tissues such as bone and
dentin. In the present study, 250-300 mu m thick, partially demineralized collagen scaffolds
exhibiting a gradient of demineralization from the base to surface were mineralized using a
classical top-down approach and a non-classical bottom-up approach. The top-down approach
involved epitaxial growth over seed crystallites. The bottom-up approach utilized biomimetic
analogs of matrix proteins to stabilize amorphous calcium phosphate nanoprecursors and template
apatite nucleation and growth within the collagen matrix. Micro-computed tomography and
transmission electron microscopy were employed to examine mineral uptake and apatite
arrangement within the mineralized collagen matrix. The top-down approach could mineralize
only the base of the partially demineralized scaffold, where remnant seed crystallites were
abundant. Minimal mineralization was observed along the surface of the scaffold; extrafibrillar
mineralization was predominantly observed. Conversely, the entire partially demineralized
scaffold, including apatite-depleted collagen fibrils, was mineralized by the bottom-up approach,
with evidence of both intrafibrillar and extrafibrillar mineralization. Understanding the different
mechanisms involved in these two mineralization approaches is pivotal in adopting the optimum
strategy for fabricating novel nanostructured materials in bioengineering research. (C) 2010 Acta
Materialia Inc. Published by Elsevier Ltd. All rights reserved. 入藏号: WOS:000288971300035 语种: English 文献类型: Article 作者关键词: Biomimetics; Bottom-up; Collagen; Particle-mediated; Mineralization; Top-down
KeyWords Plus: IN-VITRO; MECHANICAL-PROPERTIES; CALCIUM-PHOSPHATE;
DENTIN COLLAGEN; CRYSTAL-GROWTH; HARD TISSUES; REMINERALIZATION;
LESIONS; BONE; SYSTEMS 地址: [Pashley, David H.; Tay, Franklin R.] Med Coll Georgia, Sch Dent, Dept Oral Biol,
Augusta, GA 30912 USA
[Tay, Franklin R.] Med Coll Georgia, Sch Dent, Dept Endodont, Augusta, GA 30912 USA
[Liu, Yan; Mao, Jing] Huazhong Univ Sci & Technol, Dept Stomatol, Tongji Hosp, Tongji Med
Coll, Wuhan 430074, Peoples R China
[Mai, Sui] Sun Yat Sen Univ, Dept Operat Dent & Endodont, Guanghua Sch Stomatol, Guangzhou
510275, Guangdong, Peoples R China
[Li, Nan] Fujian Univ Tradit Chinese Med, Dept Osteoped & Traumatol, Fuzhou, Fujian, Peoples
R China
[Yiu, Cynthia K. Y.] Univ Hong Kong, Fac Dent, Hong Kong, Hong Kong, Peoples R China 通讯作者地址: Tay, FR (通讯作者),Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA
30912 USA 电子邮件地址: [email protected] 出版商: ELSEVIER SCI LTD
出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,
OXON, ENGLAND
Web of Science 分类: Engineering, Biomedical; Materials Science, Biomaterials 学科类别: Engineering; Materials Science
IDS 号: 742US
ISSN: 1742-7061
29 字符的来源出版物名称缩写: ACTA BIOMATER
ISO 来源出版物缩写: Acta Biomater. 来源出版物页码计数: 10 基金资助致谢: 基金资助机构 授权号
National Institute of Dental and Craniofacial Research R21 DE019213-01
Medical College of Georgia
This study was generously supported by Grant R21 DE019213-01 from the National Institute of
Dental and Craniofacial Research and the PSRP grant from the Medical College of Georgia (P.I.
Franklin R. Tay). We thank Lisha Gu for assistance with the operation of the micro-CT, Jongryul
Kim for preparing the completely demineralized specimen in the Supplementary Material, Bob
Smith for TEM technical assistance and Michelle Barnes for secretarial support.
第 56 条,共 86 条 标题 : Differential Proteomic Analysis of Temperature-Induced Autolysis in Mycelium of
Pleurotus tuber-regium 作者: Huang, BF (Huang, Bifang); Lin, WX (Lin, Wenxiong); Cheung, PCK (Cheung, Peter C.
K.); Wu, JZ (Wu, Jinzhong) 来 源 出 版 物 : CURRENT MICROBIOLOGY 卷 : 62 期 : 4 页 : 1160-1167 DOI:
10.1007/s00284-010-9838-4 出版年: APR 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 31 摘要: Autolysis is an important physiological process found in fungal cultivation. However, there
is hitherto no report on the autolysis of Pleurotus tuber-regium. We have investigated the enzymes
secreted by temperature-induced (40 degrees C as treatment versus 10 degrees C as control)
autolysis of the mycelium of P. tuber-regium grown in submerged cultivation. A comparison
between the intracellular proteins (inside the mycelium) and the extracellular proteins (in the
culture medium) of the treatment and control by proteomic analysis involving 2D PAGE and
MALDI-TOF-MS was made. Twenty-two up-regulated protein spots were detected and eight
proteins were identified. They included proteasome which participates in the ubiquitin-proteasome
pathway; beta-1,3-glucanosyltransferase and tubulin which are involved in the renewal and repair
of cell wall; protease and endoglucanase which promote the natural degradation of cell wall and
cytoplasm; 14-3-3 protein which takes part in cell signal transduction; and two putative proteins
presumably relate to the autolysis process. These identified proteins suggest partially the
metabolic processes of the autolysis in the P. tuber-regium mycelium. 入藏号: WOS:000289166800011 语种: English 文献类型: Article
KeyWords Plus: 14-3-3 PROTEINS; FR. SINGER; IDENTIFICATION; PROTEASE; BINDING;
PART 地址: [Huang, Bifang; Lin, Wenxiong] Fujian Agr & Forestry Univ, Sch Life Sci, Fuzhou 350002,
Peoples R China
[Cheung, Peter C. K.] Chinese Univ Hong Kong, Dept Biol, Shatin, Hong Kong, Peoples R China
[Wu, Jinzhong] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Peoples R
China 通讯作者地址: Lin, WX (通讯作者),Fujian Agr & Forestry Univ, Sch Life Sci, Fuzhou 350002,
Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA
Web of Science 分类: Microbiology 学科类别: Microbiology
IDS 号: 745LL
ISSN: 0343-8651
29 字符的来源出版物名称缩写: CURR MICROBIOL
ISO 来源出版物缩写: Curr. Microbiol. 来源出版物页码计数: 8
第 57 条,共 86 条 标题: Mitochondrial dysfunction in long-term neuronal cultures mimics changes with aging 作者: Dong, WG (Dong, Weiguo); Cheng, SW (Cheng, Shaowu); Huang, F (Huang, Fang); Fan,
WG (Fan, Wenguo); Chen, Y (Chen, Yue); Shi, H (Shi, Hong); He, HW (He, Hongwen) 来源出版物: MEDICAL SCIENCE MONITOR 卷: 17 期: 4 页: BR91-BR96 出版年: APR
2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 47 摘要: Background: Aging is a highly complex process that affects various tissues and systems in
the body. Senescent changes are relatively more prevalent and severe in the postmitotic cells.
Mitochondria play an important role in the aging process. Recently, cell cultures have been widely
used as an in vitro model to study aging. The present study was designed to investigate
mitochondrial dysfunction associated with aging in a long-term cell culture system.
Material/Methods: Rat hippocampal neurons were maintained in culture in serum-free medium for
30 days in vitro (DIV). The morphology and development of hippocampal neurons was observed
by phase contrast microscope. The levels of cellular senescence were evaluated by cytochemical
staining of senescence-associated beta-galactosidase (SA-beta-Gal) at DIV 5, 10, 15, 20, 25 and
30. In addition, we investigated the changes in mitochondrial membrane potential (Delta psi m)
and intracellular reactive oxygen species (ROS) generation of hippocampal neurons by flow
cytometry at different ages.
Results: The proportion of the senescent cells steadily increased with age in neuron cultures. Delta
psi m decreased gradually with age in long-term culture, while ROS generation increased.
Conclusions: This study indicates an age-related decrease in mitochondrial function in long-term
hippocampal neuronal culture and suggests that DIV 25 neurons could possibly serve as a
platform for the future study of anti-aging from the perspective of mitochondrial function. 入藏号: WOS:000289374400010 语种: English 文献类型: Article 作者关键词: senescence; mitochondrial membrane potential; reactive oxygen species; long-term
primary neuronal culture
KeyWords Plus: RAT HIPPOCAMPAL-NEURONS; IN-VITRO; CALCIUM HOMEOSTASIS;
CELLULAR SENESCENCE; CORTICAL-NEURONS; COMPLEX I; CELLS; AGE;
EXPRESSION; MELATONIN 地址: [Dong, Weiguo; Cheng, Shaowu; Huang, Fang; Fan, Wenguo; He, Hongwen] Sun Yat Sen
Univ, Guanghua Sch Stomatol, Dept Oral Anat & Physiol, Guangzhou 510080, Peoples R China
[Dong, Weiguo; Chen, Yue; Shi, Hong] Fujian Univ Tradit Chinese Med, Dept Integrated Tradit
Chinese & Western Med, Fuzhou, Peoples R China 通讯作者地址: He, HW (通讯作者),Sun Yat Sen Univ, Guanghua Sch Stomatol, Dept Oral Anat
& Physiol, Guangzhou 510080, Peoples R China 电子邮件地址: [email protected] 出版商: INT SCIENTIFIC LITERATURE, INC 出版商地址: 361 FOREST LANE, SMITHTOWN, NY 11787 USA
Web of Science 分类: Medicine, Research & Experimental 学科类别: Research & Experimental Medicine
IDS 号: 748FC
ISSN: 1234-1010
29 字符的来源出版物名称缩写: MED SCI MONITOR
ISO 来源出版物缩写: Med. Sci. Monitor 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China 30472248
This work was supported by grants from the National Natural Science Foundation of China (No.
30472248)
第 58 条,共 86 条 标题: Hepatoprotection in a Rat Model of Acute Liver Damage Through Inhibition of CY2E1
Activity by Total Alkaloids Extracted From Rubus alceifolius Poir 作者: Lin, JM (Lin, Jiumao); Zhao, JY (Zhao, Jinyan); Li, TJ (Li, Tianjiao); Zhou, JH (Zhou,
Jianheng); Hu, J (Hu, Juan); Hong, ZF (Hong, Zhenfeng) 来源出版物 : INTERNATIONAL JOURNAL OF TOXICOLOGY 卷 : 30 期 : 2 页 :
237-243 DOI: 10.1177/1091581810390711 出版年: MAR 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 27 摘要: We aimed to examine the effect of an alkaloid extract of the roots of Rubus alceifolius Poir
on liver damage and cytochrome enzymes, and underlying mechanism. Hepatotoxicity was
induced in rats by treatment with carbon tetrachloride (CCl(4)). Rats were then treated with the
hepatoprotective drug bifendate, or with low, medium, and high doses of an alkaloid extract from
the roots of R alceifolius Poir. Both bifendate and alkaloid treatment decreased the increase in
liver enzymes and cell damage caused by CCl(4). Carbon tetrachloride treatment alone caused a
decrease in total cytochrome P450 content, an increase in CYP2E1 and CYP3A1 messenger RNA
(mRNA) levels, and an increase in CYP2E1 and a decrease in CYP3A1 enzymatic activity.
Alkaloid treatment brought these concentrations and activities back toward normal. In summary,
these results suggest that alkaloids from R alceifolius Poir may act to protect the liver through
decreasing CYP2E1 enzymatic activity through decreasing its mRNA. 入藏号: WOS:000290113700011 语种: English 文献类型: Article 作者关键词: Rubus alceifolius Poir; total alkaloids; CYP2E1; CYP3A1; CYP450; drug metabolic
enzyme; acute liver damage
KeyWords Plus: CARBON-TETRACHLORIDE; APOPTOSIS; TOXICITY; INJURY; CYP2E1 地址: [Zhou, Jianheng; Hong, Zhenfeng] Fujian Univ Tradit Chinese Med, Dept Integrat Med,
Fuzhou 350108, Fujian, Peoples R China
[Lin, Jiumao; Zhao, Jinyan] Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med, Fuzhou
350108, Fujian, Peoples R China
[Li, Tianjiao] Fujian Univ Tradit Chinese Med, Affiliated Hosp 2, Fuzhou 350108, Fujian, Peoples
R China
[Hu, Juan] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108, Fujian, Peoples R
China 通讯作者地址: Hong, ZF (通讯作者),Fujian Univ Tradit Chinese Med, Dept Integrat Med,
Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: SAGE PUBLICATIONS INC 出版商地址: 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
Web of Science 分类: Pharmacology & Pharmacy; Toxicology 学科类别: Pharmacology & Pharmacy; Toxicology
IDS 号: 757UR
ISSN: 1091-5818
29 字符的来源出版物名称缩写: INT J TOXICOL
ISO 来源出版物缩写: Int. J. Toxicol. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构 授权号
Nature Science Foundation of Fujian Province of China 2006J0109
Fujian Key Laboratory of Integrative Medicine on Geriatrics (Fujian University
of TCM)
2008J1004-19
2008J1004-17
Developmental Fund of Chen Keji Integrative Medicine CKJ2008054
CKJ2008056
The author(s) disclosed receipt of the following financial support for the research and/or
authorship of this article: The project was supported by the Nature Science Foundation of Fujian
Province of China (No. 2006J0109); The Project Sponsored by Open Fund of Fujian Key
Laboratory of Integrative Medicine on Geriatrics (Fujian University of TCM)(No. 2008J1004-19
and 2008J1004-17); Developmental Fund of Chen Keji Integrative Medicine (CKJ2008054 and
CKJ2008056).
第 59 条,共 86 条 标题: Spica Prunellae extract promotes mitochondrion-dependent apoptosis in human colon
carcinoma cell line 作者: Zheng, LP (Zheng, Liangpu); Chen, YQ (Chen, Youqin); Lin, W (Lin, Wei); Zhuang, QC
(Zhuang, Qunchuan); Chen, XZ (Chen, Xuzheng); Xu, W (Xu, Wei); Liu, XX (Liu, Xianxiang);
Peng, J (Peng, Jun); Sferra, TJ (Sferra, Thomas J.) 来源出版物: AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY 卷: 5 期:
3 页: 327-335 出版年: MAR 2011 在 Web of Science 中的被引频次: 3 被引频次合计: 3 引用的参考文献数: 29 摘要: Spica Prunellae (Prunella vulgaris fruiting spikes) has long been used as an important
component in formulated prescriptions of Chinese traditional medicine to treat various kinds of
cancer. However, the precise mechanism of the anti-cancer activity of Spica Prunellae remains to
be elucidated. In this report, we investigated the cellular effects of the ethanol extract of Spica
Prunellae (EESP) in the HT-29 human colon carcinoma cell line. We found that EESP inhibited
the growth of HT-29 cells as evidenced by EESP-induced cell morphological changes and reduced
cell viability in dose-and time-dependent manners. Furthermore, we demonstrated that the HT-29
cell growth inhibitory activity of EESP was due to apoptosis, as EESP treatment resulted in the
loss of plasma membrane asymmetry (externalization of phosphatidylserine), collapse of
mitochondrial membrane potential, activation of caspase-9 and caspase-3, and increase in the ratio
of pro-apoptotic Bax to anti-apoptotic Bcl-2. Taken together, these results suggest that Spica
Prunellae inhibits the growth of HT-29 colon cancer cells through mitochondrion-mediated
apoptosis, which may, in part, explain its anti-cancer activity. 入藏号: WOS:000295797300007 语种: English 文献类型: Article 作者关键词: Apoptosis; anti-tumor; HT-29 cells; phytotherapy; mitochondria; Spica Prunellae
KeyWords Plus: CHANNEL-FORMING ACTIVITY; BCL-2 FAMILY-MEMBERS;
CYTOCHROME-C; BAX; RELEASE; DEATH; PROTEINS; CYTOSOL; CANCER; SWITCH 地址: [Zheng, Liangpu; Lin, Wei; Zhuang, Qunchuan; Chen, Xuzheng; Liu, Xianxiang; Peng, Jun]
Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China
[Chen, Youqin; Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK
73190 USA
[Xu, Wei] Fujian Univ Tradit Chinese Med, Dept Pharmacol, Fuzhou 350108, Fujian, Peoples R
China
[Chen, Youqin; Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol,
Oklahoma City, OK 73190 USA 通讯作者地址: Peng, J (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, 1
Huatuo Rd, Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: ACADEMIC JOURNALS 出版商地址: P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
Web of Science 分类: Pharmacology & Pharmacy 学科类别: Pharmacology & Pharmacy
IDS 号: 832IF
ISSN: 1996-0816
29 字符的来源出版物名称缩写: AFR J PHARM PHARMACO
ISO 来源出版物缩写: Afr. J. Pharm. Pharmacol. 来源出版物页码计数: 9 基金资助致谢: 基金资助机构 授权号
Fujian Key Laboratory of Integrative Medicine on Geriatrics 2008J1004
Natural Science Foundation of Fujian Province of China 2010J01195
Research Foundation of Education Bureau of Fujian Province of China JA10162
Developmental Fund of Chen Keji Integrative Medicine CKJ 2010019
This work was sponsored by the Open Fund of Fujian Key Laboratory of Integrative Medicine on
Geriatrics (2008J1004), the Natural Science Foundation of Fujian Province of China
(2010J01195), the Research Foundation of Education Bureau of Fujian Province of China
(JA10162), and the Developmental Fund of Chen Keji Integrative Medicine (CKJ 2010019).
第 60 条,共 86 条 标题: The critical barrier to progress in dentine bonding with the etch-and-rinse technique 作者: Brackett, MG (Brackett, M. G.); Li, N (Li, N.); Brackett, WW (Brackett, W. W.); Sword, RJ
(Sword, R. J.); Qi, YP (Qi, Y. P.); Niu, LN (Niu, L. N.); Pucci, CR (Pucci, C. R.); Dib, A (Dib, A.);
Pashley, DH (Pashley, D. H.); Tay, FR (Tay, F. R.) 来 源 出 版 物 : JOURNAL OF DENTISTRY 卷 : 39 期 : 3 页 : 238-248 DOI:
10.1016/j.jdent.2010.12.009 出版年: MAR 2011 在 Web of Science 中的被引频次: 5 被引频次合计: 5 引用的参考文献数: 63 摘要: Objectives: The lack of durability in resin-dentine bonds led to the use of chlorhexidine as
MMP-inhibitor to prevent the degradation of hybrid layers. Biomimetic remineralisation is a
concept-proven approach in preventing the degradation of resin-dentine bonds. The purpose of
this study is to examine the integrity of aged resin-dentine interfaces created with a
nanofiller-containing etch-and-rinse adhesive after the application of these two approaches.
Methods: The more established MMP-inhibition approach was examined using a parallel in vivo
and in vitro ageing design to facilitate comparison with the biomimetic remineralisation approach
using an in vitro ageing design. Specimens bonded without chlorhexidine exhibited extensive
degradation of the hybrid layer after 12 months of in vivo ageing.
Results: Dissolution of nanofillers could be seen within a water-rich zone within the adhesive
layer. Although specimens bonded with chlorhexidine exhibited intact hybrid layers, water-rich
regions remained in those hybrid layers and degradation of nanofillers occurred within the
adhesive layer. Specimens subjected to in vitro biomimetic remineralisation followed by in vitro
ageing demonstrated intrafibrillar collagen remineralisation within hybrid layers and deposition of
mineral nanocrystals in nanovoids within the adhesive.
Conclusions: The impact was realized by understanding the lack of an inherent mechanism to
remove water from resin-dentine interfaces as the critical barrier to progress in bonding with the
etch-and-rinse technique. The experimental biomimetic remineralisation strategy offers a creative
solution for incorporating a progressive hydration mechanism to achieve this goal, which warrants
its translation into a clinically applicable technique. (C) 2011 Elsevier Ltd. All rights reserved. 入藏号: WOS:000288890600008
语种: English 文献类型: Article 作者关键词: Ageing; Biomimetic remineralisation; Chlorhexidine; Degradation; Hybrid layer;
Matrix metalloproteinase
KeyWords Plus: MULTIPLE WATER COMPARTMENTS; THERMAL STABILIZATION;
IN-VIVO; MATRIX METALLOPROTEINASES; MECHANICAL-PROPERTIES; RESIN
HYDROPHILICITY; ARCHAEOLOGICAL BONE; POLYMER COMPOSITES; COLLAGEN
MOLECULES; HYBRID LAYERS 地址: [Tay, F. R.] Med Coll Georgia, Sch Dent, Dept Endodont, Augusta, GA 30912 USA
[Brackett, M. G.; Brackett, W. W.; Sword, R. J.] Med Coll Georgia, Sch Dent, Dept Oral Rehabil,
Augusta, GA 30912 USA
[Li, N.] Fujian Univ Tradit Chinese Med, Coll Osteoped & Traumatol, Fuzhou, Fujian, Peoples R
China
[Qi, Y. P.] Sun Yat Sen Univ, Guanghua Sch Stomatol, Dept Operat Dent & Endodont, Guangzhou
510275, Guangdong, Peoples R China
[Niu, L. N.] Fourth Mil Med Univ, Sch Stomatol, Dept Prosthodont, Xian 710032, Peoples R
China
[Pucci, C. R.] Univ Estadual Paulista, UNESP, Fac Odontol Sao Jose dos Campos, Sao Paulo,
Brazil
[Dib, A.] Benemerita Univ Autonoma Puebla, Fac Estomatol, Puebla, Mexico
[Pashley, D. H.; Tay, F. R.] Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA 30912 USA 通讯作者地址: Tay, FR (通讯作者),Med Coll Georgia, Sch Dent, Dept Endodont, 1120,15th
St,CL 2132, Augusta, GA 30912 USA 电子邮件地址: [email protected] 出版商: ELSEVIER SCI LTD 出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,
OXON, ENGLAND
Web of Science 分类: Dentistry, Oral Surgery & Medicine 学科类别: Dentistry, Oral Surgery & Medicine
IDS 号: 741UL
ISSN: 0300-5712
29 字符的来源出版物名称缩写: J DENT
ISO 来源出版物缩写: J. Dent. 来源出版物页码计数: 11 基金资助致谢: 基金资助机构 授权号
Benemerita Universidad Autonoma de Puebla, Mexico
National Institute of Dental and Craniofacial Research
R01 DE015306-06
R21 DE019213-01
The in vivo part of this study was funded by the Benemerita Universidad Autonoma de Puebla,
Mexico. The in vitro part of the study was supported by the National Institute of Dental and
Craniofacial Research. Specifically, the funds were used to support transmission electron
microscopy (R01 DE015306-06; PI. David H. Pashley) and biomimetic remineralisation of
resin-dentine bonds (R21 DE019213-01; PI. Franklin R. Tay). We thank Michelle Barnes for her
secretarial support and Thomas Bryan for his technical support.
第 61 条,共 86 条 标题: Patrinia scabiosaefolia extract suppresses proliferation and promotes apoptosis by inhibiting
the STAT3 pathway in human multiple myeloma cells 作者: Peng, J (Peng, Jun); Chen, YQ (Chen, Youqin); Lin, JM (Lin, Jiumao); Zhuang, QC
(Zhuang, Qunchuan); Xu, W (Xu, Wei); Hong, ZF (Hong, Zhenfeng); Sferra, TJ (Sferra, Thomas
J.) 来源出版物 : MOLECULAR MEDICINE REPORTS 卷 : 4 期 : 2 页 : 313-318 DOI:
10.3892/mmr.2011.413 出版年: MAR-APR 2011 在 Web of Science 中的被引频次: 2 被引频次合计: 2 引用的参考文献数: 30 摘要: Signal transducer and activator of transcription 3 (STAT3) plays an important role in tumor
cell survival and proliferation and thus has become a major focus in the development of
anti-cancer therapies. Patrinia scabiosaefolia has been used for the treatment of various types of
cancer. However, the precise mechanism of the anti-cancer activity of Patrinia scabiosaefolia
remains unclear. In this study, we evaluated the effect of the ethanol extract of Patrinia
scabiosaefolia (EEPS) on proliferation and apoptosis in human multiple myelorna U266 cells that
persistently express phosphorylated STAT3, and investigated the possible molecular mechanisms
mediating its biological effects. We found that EEPS inhibited the phosphorylation of STAT3 in
U266 cells. Consequently, the inhibitory effect of EEPS on STAT3 activation resulted in the
suppression of cell proliferation and the induction of cell apoptosis. Moreover, EEPS treatment
inhibited the expression of cyclin D1 (a promoter of cell proliferation) and Bcl-2 (an inhibitor of
apoptosis), two important target genes of the STAT3 signaling pathway. Our findings for the first
time demonstrate that Patrinia scabiosaefolia inhibits proliferation and promotes the apoptosis of
cancer cells via inhibition of the STAT3 pathway, which may in part explain its anti-cancer
activity. 入藏号: WOS:000287785800019 语种: English 文献类型: Article 作者关键词: anti-tumor; U266 cells; phytotherapy; signal transducer and activator of transcription
3 pathway; Patrinia scabiosaefolia
KeyWords Plus: INTESTINAL EPITHELIAL-CELLS; EPIDERMAL-GROWTH-FACTOR;
SIGNAL TRANSDUCER; CONSTITUTIVE ACTIVATION; COLORECTAL-CANCER;
MOLECULAR TARGETS; NATURAL-PRODUCTS; DRUG DISCOVERY;
TRANSCRIPTION-3; CARCINOMA 地址: [Peng, Jun; Lin, Jiumao; Zhuang, Qunchuan; Hong, Zhenfeng] Fujian Univ Tradit Chinese
Med, Acad Integrat Med, Fuzhou 350108, Fujian, Peoples R China
[Xu, Wei] Fujian Univ Tradit Chinese Med, Dept Pharmacol, Fuzhou 350108, Fujian, Peoples R
China
[Chen, Youqin; Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK
73190 USA
[Sferra, Thomas J.] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, Oklahoma City, OK
73190 USA 通讯作者地址: Hong, ZF (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, 1
Huatuo Rd, Fuzhou 350108, Fujian, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE
Web of Science 分类: Oncology; Medicine, Research & Experimental 学科类别: Oncology; Research & Experimental Medicine
IDS 号: 727GK
ISSN: 1791-2997
29 字符的来源出版物名称缩写: MOL MED REP
ISO 来源出版物缩写: Mol. Med. Rep. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
Fujian Key Laboratory of Integrative Medicine on Geriatrics 2008J1004
Natural Science Foundation of Fujian Province 2010J01195
National Natural Science Foundation of China 81073097
Chen Keji Integrative Medicine CKJ 2010019
This study was sponsored by the Open Fund of Fujian Key Laboratory of Integrative Medicine on
Geriatrics (2008J1004), the Natural Science Foundation of Fujian Province (2010J01195), the
National Natural Science Foundation of China (81073097) and the Developmental Fund of Chen
Keji Integrative Medicine (CKJ 2010019).
第 62 条,共 86 条 标题: Chromatographic Fingerprint and Quantitative Analysis of Seven Bioactive Compounds of
Scutellaria barbata
作者: Yao, H (Yao, Hong); Li, SG (Li, Shaoguang); Hu, JA (Hu, Juan); Chen, Y (Chen, Yan);
Huang, LY (Huang, Liying); Lin, JH (Lin, Jianhua); Li, GW (Li, Guangwen); Lin, XH (Lin,
Xinhua) 来源出版物: PLANTA MEDICA 卷: 77 期: 4 页: 388-393 DOI: 10.1055/s-0030-1250353 出版年: MAR 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 23 摘要: Scutellaria barbata D. Don is widely used as a folk antitumor and anti-inflammatory agent
in Asia. However, a simple and global quality control method for S. barbata was lacking. In this
study, six phenolic compounds, including p-coumaric acid, scutellarin, apigenin
5-O-beta-glucopyranoside, luteolin, apigenin and 4'-hydroxywogonin were obtained from S.
barbata by phytochemical investigations. The six compounds plus baicalein show cytotoxcities to
the nine human cancer cells, K562, MGC-803, HL60, SH-SY5Y, SW1116, SMMC-7221, SW480,
HepG2 and KB. Subsequently, a high-performance liquid chromatography with photodiode array
detector (HPLC-DAD) was developed for both fingerprint analysis of S. barbata and quantitative
determination of the seven anticancer active compounds in S. barbata. The chromatographic
separation was accomplished on an Ultimate (TM) XB-C18 column (4.6 x 250 mm, 5 mu m) in 65
min. For fingerprinting, 26 common peaks were found and selected as characteristic peaks to
assess the consistency of S. barbata samples. For quantitative analysis, the seven bioactive
compounds showed good regression relationship (R(2) > 0.999) within test ranges and the
recovery of the method was in the range of 90-105%. In brief, the present study provides the
fingerprint analysis and quantitative methods for global and systematical quality control of S.
barbata for its anticancer usage. 入藏号: WOS:000288116200014 语种: English 文献类型: Article 作者关键词: Scutellaria barbata; Labiatae; chromatographic fingerprint; phenolic components;
cytotoxicity; quantity control; HPLC-DAD
KeyWords Plus: QUALITY-CONTROL; APOPTOSIS; RIVULARIS; CELLS 地址: [Yao, Hong; Li, Shaoguang; Chen, Yan; Huang, Liying; Li, Guangwen; Lin, Xinhua] Fujian
Med Univ, Dept Pharmaceut Anal, Fac Pharm, Fuzhou 350004, Fujian, Peoples R China
[Hu, Juan] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou, Fujian, Peoples R China
[Lin, Jianhua] Fujian Med Univ, Affiliated Hosp 1, Dept Orthoped, Fuzhou 350004, Fujian,
Peoples R China 通讯作者地址: Lin, XH (通讯作者),Fujian Med Univ, Dept Pharmaceut Anal, Fac Pharm,
Fuzhou 350004, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: GEORG THIEME VERLAG KG 出版商地址: RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
Web of Science 分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
学科类别: Plant Sciences; Pharmacology & Pharmacy
IDS 号: 731NQ
ISSN: 0032-0943
29 字符的来源出版物名称缩写: PLANTA MED
ISO 来源出版物缩写: Planta Med. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
foundation of National High Technology and Development of China 2007AA02Z4A4
Fujian Provincial Education Department Foundation JA07101
Fujian Provincial Natural Science Foundation 2009J01157
Fujian Provincial Health Department Foundation 2008-1-20
Preclinical Study of Traditional Chinese Medicine and Quality Control
Engineering Technology Center of Fujian Province of China for help in
equipment and technology
2009Y2003
The authors gratefully acknowledge the financial support of the foundation of National High
Technology and Development of China (863 projects: 2007AA02Z4A4), the Fujian Provincial
Education Department Foundation (JA07101) the Fujian Provincial Natural Science Foundation
(2009J01157), the Fujian Provincial Health Department Foundation (2008-1-20) and Preclinical
Study of Traditional Chinese Medicine and Quality Control Engineering Technology Center of
Fujian Province of China for help in equipment and technology (2009Y2003).
第 63 条,共 86 条 标题: Formation mechanism of propagated sensation along the meridians, as verified by cortical
somatosensory-evoked potential topographic maps 作者: Xu, JS (Xu, Jinsen); Pan, XH (Pan, Xiaohua); Zheng, SX (Zheng, Shuxia); Hu, XL (Hu,
Xianglong); Sa, ZY (Sa, Zheyan) 来源出版物 : NEURAL REGENERATION RESEARCH 卷 : 6 期 : 6 页 : 435-439 DOI:
10.3969/j.issn.1673-5374.2011.06.006 出版年: FEB 25 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 20 摘要: The peripheral driver stimulating theory states that as a driver passes along a certain
meridian during acupuncture; the driver provokes nerve sense devices along the meridian,
resulting in the nerve impulse entering the central nervous system. Accordingly, volunteers have
reported propagated sensations along the meridians (PSM). The present study was designed to
utilize a cortical somatosensory-evoked potential (CSEP) topographic map for determining
whether stimulation expansion occurs in somatosensory area I when sensation was provoked in
individuals with obvious PSM. The sensation was blocked by mechanical compression, and the
sensation was imitated in individuals without PSM. Results revealed a red, high-potential signal in
the representative area of the lower limbs in individuals with obvious PSM symptoms when the
Gall Bladder Meridian (GBM) sensation passed to the head and face. This representative area was
near the middle line of the CSEP topographic map, and a red, high-potential signal, which jumps
over the representative area of the upper limbs, also appeared in the representative face area,
which was at the external region of the CSEP topographic map. However, in individuals exhibiting
no PSM, only a red high-potential signal appeared in the representative lower limb area. When
Hegu (LI 4) was stimulated in individuals without PSM, an obvious evoked response appeared
only in the representative upper limb area. However, when Hegu was stimulated in individuals
exhibiting PSM, the response area was larger in the representative upper limb area and extended to
the representative face area. When Guangming (GB 37) was stimulated in PSM individuals, the
face representation response disappeared and was confined to a foot representation of the
somatosensory area I when PSM was blocked by mechanical pressure. Results suggested that
mechanical compression blocked PSM, and corresponding changes were exhibited in the CSEP
topographic map. These results provide compelling evidence for the hypothesis that peripheral
driver stimulation is the key element in producing PSM. 入藏号: WOS:000288931100006 语种: English 文献类型: Article 作者关键词: propagated sensation along the meridians; meridian; cortical somatosensory-evoked
potential; evoked potential topographic map
KeyWords Plus: STIMULATION; REPRESENTATION; CORTEX 地址: [Xu, Jinsen; Pan, Xiaohua; Zheng, Shuxia; Hu, Xianglong; Sa, Zheyan] Fujian Acad Tradit
Chinese Med, Key Unit Propagated Sensat Meridian, State Adm Tradit Chinese Med, Fuzhou
350003, Fujian Province, Peoples R China 通讯作者地址: Xu, JS (通讯作者),Fujian Acad Tradit Chinese Med, Key Unit Propagated Sensat
Meridian, State Adm Tradit Chinese Med, Fuzhou 350003, Fujian Province, Peoples R China 电子邮件地址: [email protected] 出版商: SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES 出版商地址: PO BOX 1234, SHENYANG, LIAONING 110004, PEOPLES R CHINA
Web of Science 分类: Cell Biology; Neurosciences 学科类别: Cell Biology; Neurosciences & Neurology
IDS 号: 742HE
ISSN: 1673-5374
29 字符的来源出版物名称缩写: NEURAL REGEN RES
ISO 来源出版物缩写: Neural Regen. Res. 来源出版物页码计数: 5 基金资助致谢:
基金资助机构 授权号
National Natural Science Foundation of China 30973720
Science Research Foundation of Ministry of Health
United Fujian Provincial Health and Education Project WKJ2005-2-004
This study was supported by the National Natural Science Foundation of China, No. 30973720;
the Science Research Foundation of Ministry of Health and United Fujian Provincial Health and
Education Project for Tackling the Key Research of China, No. WKJ2005-2-004.
第 64 条,共 86 条 标题: Intrafibrillar Collagen Mineralization Produced by Biomimetic Hierarchical Nanoapatite
Assembly 作者: Liu, Y (Liu, Yan); Li, N (Li, Nan); Qi, YP (Qi, Yi-pin); Dai, L (Dai, Lin); Bryan, TE (Bryan,
Thomas E.); Mao, J (Mao, Jing); Pashley, DH (Pashley, David H.); Tay, FR (Tay, Franklin R.) 来 源 出 版 物 : ADVANCED MATERIALS 卷 : 23 期 : 8 页 : 975-980 DOI:
10.1002/adma.201003882 出版年: FEB 22 2011 在 Web of Science 中的被引频次: 4 被引频次合计: 4 引用的参考文献数: 52 入藏号: WOS:000287669000004 语种: English 文献类型: Article
KeyWords Plus: CALCIUM-PHOSPHATE; COMPOSITE SCAFFOLD; MATRIX PROTEIN;
BONE-STRUCTURE; IN-VITRO; FIBRILS; PRECURSOR; HYDROXYAPATITE;
NUCLEATION; NANOSCALE 地址: [Bryan, Thomas E.; Pashley, David H.; Tay, Franklin R.] Med Coll Georgia, Sch Dent, Dept
Oral Biol, Augusta, GA 30912 USA
[Bryan, Thomas E.; Pashley, David H.; Tay, Franklin R.] Med Coll Georgia, Dept Endodont,
Augusta, GA 30912 USA
[Dai, Lin] First Hosp Wuhan, Dept Stomatol, Wuhan, Peoples R China
[Qi, Yi-pin] Sun Yat Sen Univ, Guanghua Sch Stomatol, Dept Operat Dent & Endodont,
Guangzhou 510275, Guangdong, Peoples R China
[Li, Nan] Fujian Univ Tradit Chinese Med, Coll Osteoped & Traumatol, Fuzhou, Fujian, Peoples
R China
[Liu, Yan; Mao, Jing] Huazhong Univ Sci & Technol, Dept Stomatol, Tongji Hosp, Tongji Med
Coll, Wuhan 430074, Peoples R China 通讯作者地址: Tay, FR (通讯作者),Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA
30912 USA 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL
出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Web of Science 分类 : Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed
Matter 学科类别: Chemistry; Science & Technology - Other Topics; Materials Science; Physics
IDS 号: 725TM
ISSN: 0935-9648
29 字符的来源出版物名称缩写: ADV MATER
ISO 来源出版物缩写: Adv. Mater. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
NIDCR R21 DE019213
Medical College of Georgia
This work was supported by grant R21 DE019213 from NIDCR (P.I., F.T.) and the PSRP award
from the Medical College of Georgia. We thank Michelle Barnes for secretarial support, Jongryul
Kim for SEM preparation, and Robert Smith for TEM assistance.
第 65 条,共 86 条 标题: Anticolchicine Cytotoxicity Enhanced by Dan Gua-Fang (sic), A Chinese Herb Prescription
in ECV304 in Mediums 作者: Heng, XP (Heng Xian-pei); Chen, KJ (Chen Ke-ji); Hong, ZF (Hong Zhen-feng); He, WD
(He Wei-dong); Chu, KD (Chu Ke-dan); Chen, WL (Chen Wen-lie); Zheng, HX (Zheng Hai-xia);
Yang, LQ (Yang Liu-qing); Chen, L (Chen Ling); Guo, F (Guo Fang) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 2 页 :
126-133 DOI: 10.1007/s11655-011-0646-X 出版年: FEB 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 12 摘要: Objective: To study the effect of anticolchicine cytotoxicity of Dan Gua-Fang (sic), a
Chinese herbal compound prescription on endothelial cells of vein (ECV304) cultivated in
mediums of different glucose concentrations as well as the proliferation of those cells in the same
conditions, in order to reveal the value of Dan Gua-Fang in preventing and treating endothelial
damage caused by hyperglycemia in diabetes mellitus. Methods: The research was designed as
three stages. The growing state and morphological changes were observed when ECV304 were
cultivated in the culture mediums, which have different glucose concentrations with or without
Dan Gua-Fang and at the same time with or without colchicine. Results: (1) Dan Gua-Fang at all
concentrations reduced the floating cell population of ECV304 cultivated in hyperglycemia
mediums. (2) Dan Gua-Fang at all concentrations and hyperglycemia both had a function of
promoting "pseudopod-like" structure formation in cultivated ECV304, but the function was not
superimposed in mediums containing both hyperglycemia and Dan Gua-Fang. (3) Colchicine
reduced and even vanished the "pseudopod-like" structure of the endotheliocyte apparently
cultivated in mediums of hyperglycemia or with Dan Gua-Fang. The "pseudopod-like" structure of
the endotheliocyte emerged quickly in Dan Gua-Fang groups after colchicine was removed, but it
was not the case in hyperglycemia only without Dan Gua-Fang groups. (4) Dan Gua-Fang reduced
the mortality of cells cultivated in mediums containing colchicine. The cell revived to its normal
state fast after colchicine was removed. Conclusion: Dan Gua-Fang has the functions of promoting
the formation of cytoskeleton and fighting against colchicine cytotoxicity. 入藏号: WOS:000286908700009 语种: English 文献类型: Article 作者关键词: Dan Gua-Fang; endothelial cell; colchicine; diabetes mellitus
KeyWords Plus: ENDOTHELIAL-CELLS; HYPERGLYCEMIA 地址: [Heng Xian-pei; He Wei-dong; Chu Ke-dan; Zheng Hai-xia; Yang Liu-qing; Guo Fang]
Fujian Univ, Dept Endocrinol, Peoples Hosp Affiliated, Fuzhou 350004, Peoples R China
[Heng Xian-pei; Chen Ke-ji] China Acad Chinese Med Sci, Beijing 100091, Peoples R China
[Hong Zhen-feng; Chen Ling] Fujian Univ Tradit Chinese Med, Fuzhou 350108, Peoples R China
[Chen Ke-ji; Chen Wen-lie] Fujian Inst Integrat Chinese & Western Med, Fuzhou 350108, Peoples
R China 通讯作者地址: Heng, XP (通讯作者),Fujian Univ, Dept Endocrinol, Peoples Hosp Affiliated,
Fuzhou 350004, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA
Web of Science 分类: Integrative & Complementary Medicine 学科类别: Integrative & Complementary Medicine
IDS 号: 715SU
ISSN: 1672-0415
29 字符的来源出版物名称缩写: CHIN J INTEGR MED
ISO 来源出版物缩写: Chin. J. Integr. Med. 来源出版物页码计数: 8 基金资助致谢: 基金资助机构 授权号
China Postdoctoral Science Foundation 20070410128
CHEN Ke-ji Development Fund of Integrative Medicine CKJ2006001
Science Foundation of Health Department, Fujian Province WZY0618
Supported by the China Postdoctoral Science Foundation (No. 20070410128), CHEN Ke-ji
Development Fund of Integrative Medicine (No. CKJ2006001) and Science Foundation of Health
Department, Fujian Province (No. WZY0618)
第 66 条,共 86 条 标题: Hierarchical and non-hierarchical mineralisation of collagen 作者: Liu, Y (Liu, Yan); Kim, YK (Kim, Young-Kyung); Dai, L (Dai, Lin); Li, N (Li, Nan); Khan,
SO (Khan, Sara O.); Pashley, DH (Pashley, David H.); Tay, FR (Tay, Franklin R.) 来 源 出 版 物 : BIOMATERIALS 卷 : 32 期 : 5 页 : 1291-1300 DOI:
10.1016/j.biomaterials.2010.10.018 出版年: FEB 2011 在 Web of Science 中的被引频次: 11 被引频次合计: 11 引用的参考文献数: 51 摘要: Biomineralisation of collagen involves functional motifs incorporated in extracellular
matrix protein molecules to accomplish the objectives of stabilising amorphous calcium phosphate
into nanoprecursors and directing the nucleation and growth of apatite within collagen fibrils.
Here we report the use of small inorganic polyphosphate molecules to template hierarchical
intrafibrillar apatite assembly in reconstituted collagen in the presence of polyacrylic acid to
sequester calcium and phosphate into transient amorphous nanophases. The use of polyphosphate
without a sequestration analogue resulted only in randomly-oriented extrafibrillar precipitations
along the fibrillar surface. Conversely, the use of polyacrylic acid without a templating analogue
resulted only in non-hierarchical intrafibrillar mineralisation with continuous apatite strands
instead of discrete crystallites. The ability of using simple non-protein molecules to recapitulate
different levels of structural hierarchy in mineralised collagen signifies the ultimate simplicity in
Nature's biomineralisation design principles and challenges the need for using more complex
recombinant matrix proteins in bioengineering applications. (C) 2010 Elsevier Ltd. All rights
reserved. 入藏号: WOS:000287073000005 语种: English 文献类型: Article 作者关键词: Biomineralisation; Non-protein molecules; Hierarchical intrafibrillar mineralisation;
Crossbanding; Non-hierarchical intrafibrillar mineralisation; Extrafibrillar mineralisation
KeyWords Plus: AMORPHOUS CALCIUM-PHOSPHATE; BIOMINERALIZATION; BONE;
PHOSPHORYLATION; PROTEINS; NUCLEATION; CRYSTALS; FIBRILS; DENTIN;
HYDROXYAPATITE 地址: [Pashley, David H.; Tay, Franklin R.] Med Coll Georgia, Sch Dent, Dept Oral Biol,
Augusta, GA 30912 USA
[Tay, Franklin R.] Med Coll Georgia, Sch Dent, Dept Endodont, Augusta, GA 30912 USA
[Liu, Yan] Huazhong Univ Sci & Technol, Dept Stomatol, Tongji Hosp, Tongji Med Coll, Wuhan
430074, Peoples R China
[Kim, Young-Kyung] Kyungpook Natl Univ, Sch Dent, Dept Conservat Dent, Taegu, South Korea
[Dai, Lin] First Hosp Wuhan, Dept Stomatol, Wuhan, Peoples R China
[Li, Nan] Fujian Univ Tradit Chinese Med, Dept Osteoped & Traumatol, Fuzhou, Fujian, Peoples
R China 通讯作者地址: Tay, FR (通讯作者),Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA
30912 USA 电子邮件地址: [email protected] 出版商: ELSEVIER SCI LTD 出版商地址: THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,
OXON, ENGLAND
Web of Science 分类: Engineering, Biomedical; Materials Science, Biomaterials 学科类别: Engineering; Materials Science
IDS 号: 717UN
ISSN: 0142-9612
29 字符的来源出版物名称缩写: BIOMATERIALS
ISO 来源出版物缩写: Biomaterials 来源出版物页码计数: 10 基金资助致谢: 基金资助机构 授权号
NIDCR R21 DE019213
This work was supported by grant R21 DE019213 from NIDCR (PI. Franklin Tay). We thank
Michelle Barnes for secretarial support, Robert Smith for TEM assistance.
第 67 条,共 86 条 标题: Acanthopanax senticosus: review of botany, chemistry and pharmacology 作者 : Huang, LZ (Huang, LinZhang); Zhao, HF (Zhao, HongFang); Huang, BK (Huang,
BaoKang); Zheng, CJ (Zheng, ChengJian); Peng, W (Peng, Wei); Qin, LP (Qin, LuPing) 来源出版物: PHARMAZIE 卷: 66 期: 2 页: 83-97 DOI: 10.1691/ph.2011.0744 出版年: FEB
2011 在 Web of Science 中的被引频次: 3 被引频次合计: 3 引用的参考文献数: 103 摘要: Acanthopanax senticosus (Rupr. et Maxim) Harms (Araliaceae), also called Siberian
Ginseng, Eleutherococcus senticosus, and Ciwujia in Chinese, is a widely used traditional Chinese
herb that could invigorate qi, strengthen the spleen, and nourish kidney in the theory of Traditional
Chinese Medicine. With high medicinal value, Acanthopanax senticosus (AS, thereafter) is
popularly used as an "adaptogen" like Panax ginseng. In recent decades, a great number of
chemical, pharmacological, and clinical studies on AS have been carried out worldwide. Several
kinds of chemical compounds have been reported, including triterpenoid saponins, lignans,
coumarins, and flavones, among which, phenolic compounds such as syringin and eleutheroside E,
were considered to be the most active components. Considerable pharmacological experiments
both in vitro and in vivo have persuasively demonstrated that AS possessed anti-stress, anti-ulcer,
anti-irradiation, anticancer, anti-inflammatory and hepatoprotective activities, etc. The present
review is an up-to-date and comprehensive analysis of the botany, chemistry, pharmacology,
toxicity and clinical trials of AS. 入藏号: WOS:000288052700001 语种: English 文献类型: Review
KeyWords Plus: PERFORMANCE LIQUID-CHROMATOGRAPHY; CELL-DEPENDENT
ANAPHYLAXIS; MACROPHAGES IN-VITRO; ELEUTHEROCOCCUS-SENTICOSUS;
SIBERIAN GINSENG; PANAX-GINSENG; TRITERPENOID SAPONINS;
PLATELET-AGGREGATION; ACTIVE PRINCIPLE; ELEUTHEROSIDE-B 地址: [Huang, LinZhang; Zhao, HongFang; Huang, BaoKang; Zheng, ChengJian; Peng, Wei; Qin,
LuPing] Mil Med Coll 2, Dept Pharmacognosy, Sch Pharm, Shanghai 200433, Peoples R China
[Huang, LinZhang; Zhao, HongFang] Fujian Univ Tradit Chinese Med, Dept Pharm, Sch Pharm,
Fuzhou, Peoples R China 通讯作者地址: Qin, LP (通讯作者),Mil Med Coll 2, Dept Pharmacognosy, Sch Pharm, 325
Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected] 出版商: GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH 出版商地址 : PHARMAZEUTISCCARL MANNICH STR 26, D-65760 ESCHBORN,
GERMANY
Web of Science 分类: Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
Pharmacy 学科类别: Pharmacology & Pharmacy; Chemistry
IDS 号: 730RU
ISSN: 0031-7144
29 字符的来源出版物名称缩写: PHARMAZIE
ISO 来源出版物缩写: Pharmazie 来源出版物页码计数: 15
第 68 条,共 86 条 标题 : Qualitative and Quantitative Analysis of Alkaloids in Cortex Phellodendri by
HPLC-ESI-MS/MS and HPLC-DAD 作者: Zhu, SL (Zhu Shuang-lai); Dou, SS (Dou Sheng-shan); Liu, XR (Liu Xin-ru); Liu, RH (Liu
Run-Hui); Zhang, WD (Zhang Wei-dong); Huang, HL (Huang Hong-lin); Zhang, Y (Zhang Yi);
Hu, YH (Hu Yao-hua); Wang, SP (Wang Shu-ping) 来源出版物: CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 卷: 27 期: 1 页:
38-44 出版年: JAN 25 2011
在 Web of Science 中的被引频次: 2 被引频次合计: 2 引用的参考文献数: 28 摘要: A combined method of high performance liquid chromatograph-elecrtrospray-ionization
mass spectrometer(HPLC-ESI-MS/MS) coupled with a photodiode array detector(HPLC-DAD)
and principal component analysis(PCA) was applied to the qualitative and quantitative analyses of
alkaloids in Cortex Phellodendri(CP) samples, and to the differentiation of two species of CP,
Cortex Phellodendri Chinensis(CPC) and Cortex Phellodendri Amurensis(CPA). Twenty-two
peaks appeared in the HPLC-MS base peak chromatogram of CP detected by the
HPLC-ESI-MS/MS analysis, and the alkaloids were identified according to the MS(n) data, the
known MS fragmentation rules and the literature data. Five alkaloids including berberine,
palmatine, jatrorrhizine, phellodendrine and magnoflorine were simultaneously determinated by
the HPLC-DAD. Berberine was the primary component in all CP samples, and the contents of
berberine and palmatine were exploited to be two critical parameters for effective discrimination
between the two species of CP. The average content of berberine in CPC(58.75 mg/g) was higher
than that in CPA(9.16 mg/g), while the content of palmatine was less, only 0.25 mg/g in CPC and
4.19 mg/g in CPA. With the use of PCA, samples datasets were separated successfully into two
different clusters corresponding to the two species, and berberine, palmatine, phellodendrine and
magnoflorine contribute most to the above mentioned calssifying. The proposed method proved to
be a useful tool in the quality control of Chinese herbal medicines. 入藏号: WOS:000287825400009 语种: English 文献类型: Article 作者关键词 : Cortex Phellodendri; Alkaloid; HPLC-ESI-MS/MS; Quantitative analysis;
Qualitative analysis; Principal component analysis
KeyWords Plus: PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM
MASS-SPECTROMETRY; PROTOBERBERINE ALKALOIDS; IDENTIFICATION;
CHEMOMETRICS; SPECTROSCOPY 地址: [Zhu Shuang-lai; Dou Sheng-shan; Liu Xin-ru; Liu Run-Hui; Zhang Wei-dong; Hu Yao-hua;
Wang Shu-ping] Mil Med Coll 2, Sch Pharm, Shanghai 200433, Peoples R China
[Zhu Shuang-lai; Huang Hong-lin] Jiangxi Univ Tradit Chinese Med, Sch Pharm, Nanchang
330004, Peoples R China
[Zhang Wei-dong] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China
[Hu Yao-hua] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350108, Peoples R China
[Zhang Yi] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 610075, Peoples R China 通讯作者地址: Liu, RH (通讯作者),Mil Med Coll 2, Sch Pharm, Shanghai 200433, Peoples R
China 电子邮件地址: [email protected] 出版商: HIGHER EDUCATION PRESS 出版商地址: SHATANHOU ST 55, BEIJING 100009, PEOPLES R CHINA
Web of Science 分类: Chemistry, Multidisciplinary
学科类别: Chemistry
IDS 号: 727TN
ISSN: 1005-9040
29 字符的来源出版物名称缩写: CHEM RES CHINESE U
ISO 来源出版物缩写: Chem. Res. Chin. Univ. 来源出版物页码计数: 7 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China 30725045
Foundation of Eleventh Five-Year-Plan of China 2008ZX09202-002
Shanghai Leading Academic Discipline Project, China B906
Scientific Foundation of Shanghai City, China 07DZ19702
Supported by the National Natural Science Foundation of China(No.30725045), the Foundation of
Eleventh Five-Year-Plan of China(No.2008ZX09202-002), the Shanghai Leading Academic
Discipline Project, China(No.B906) and the Scientific Foundation of Shanghai City,
China(No.07DZ19702).
第 69 条,共 86 条 标题: Bioactivity-guided fractionation for anti-fatigue property of Acanthopanax senticosus 作者: Huang, LZ (Huang, Lin-Zhang); Huang, BK (Huang, Bao-Kang); Ye, Q (Ye, Qi); Qin, LP
(Qin, Lu-Ping) 来源出版物: JOURNAL OF ETHNOPHARMACOLOGY 卷: 133 期: 1 页: 213-219 DOI:
10.1016/j.jep.2010.09.032 出版年: JAN 7 2011 在 Web of Science 中的被引频次: 5 被引频次合计: 5 引用的参考文献数: 27 摘要 : Ethnopharmacological relevance: The root of Acanthopanax senticosus (also called
Eleutherococcus senticosus or Siberian ginseng) has been used extensively in China, Russia and
Japan as an adaptogen to fight against stress and fatigue.
Aim of the study: The present study was designed to ascertain the anti-fatigue property of
Acanthopanax senticosus by load-weighted swimming test, sleep deprivation test, also to isolate
and characterize the active constituents.
Materials and methods: Animals were orally administered with the extract of Acanthopanax
senticosus. The anti-fatigue effects of the four fractions with different polarities from the 80%
ethanol extract, and the different eluates collected from D101 macroporous resin chromatography
and eleutheroside E, were examined based on the weight-loaded swimming capacity (physical
fatigue) and the change of biochemical parameters in ICR mice. Moreover, the active fraction was
later submitted to sleep-deprived mice (mental fatigue).
Results: The results shown that the n-butanol fraction significant extends the swimming time of
mice to exhaustion. Furthermore, the 60% ethanol-water eluate, more purified eleutherosides
(including eleutheroside E. E(2) and derivatives), were the exactly active constituents. Two
compounds were isolated, which were identified as eleutheroside E, E(2).
Conclusions:The eleutherosides possess the potent abilities to alleviate fatigue both in physical
and mental fatigue. Eleutheroside E may be responsible for the pharmacological effect of
anti-fatigue. Furthermore, the possible mechanisms were reduced the level of TG by increasing fat
utilization, delayed the accumulation of blood urea nitrogen (BUN), and increased the LDH to
reduce the accumulation of lactic acid in muscle and then protect the muscle tissue. (C) 2010
Elsevier Ireland Ltd. All rights reserved. 入藏号: WOS:000286854100029 语种: English 文献类型: Article 作 者 关 键 词 : Acanthopanax senticosus; Eleutherococcus senticosus; Anti-fatigue;
Bioassay-guided; Sleep-deprived; Behavioral; Macroporous resin
KeyWords Plus: ELEUTHEROCOCCUS-SENTICOSUS; MICE; MEMORY; RATS;
CONSTITUENTS; EXTRACTS; STRESS 地址: [Huang, Lin-Zhang; Huang, Bao-Kang; Ye, Qi; Qin, Lu-Ping] Mil Med Coll 2, Sch Pharm,
Dept Pharmacognosy, Shanghai 200433, Peoples R China
[Huang, Lin-Zhang] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou 350108, Peoples R
China 通讯作者地址: Qin, LP (通讯作者),Mil Med Coll 2, Sch Pharm, Dept Pharmacognosy, 325
Guohe Rd, Shanghai 200433, Peoples R China 电子邮件地址: [email protected] 出版商: ELSEVIER IRELAND LTD 出版商地址: ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO,
CLARE, 00000, IRELAND
Web of Science 分类: Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
Medicine; Pharmacology & Pharmacy 学科类别: Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine
IDS 号: 715AZ
ISSN: 0378-8741
29 字符的来源出版物名称缩写: J ETHNOPHARMACOL
ISO 来源出版物缩写: J. Ethnopharmacol. 来源出版物页码计数: 7
第 70 条,共 86 条 标题 : Comparison of Adjunctive Naoxintong versus Clopidogrel in Volunteers with the
CYP2C19*2 Gene Mutation Accompanied with Qi Deficiency and Blood Stasis Constitution 作者: Chen, H (Chen, Hui); Yu, GW (Yu, Guangwei); Sun, H (Sun, Hong); Wu, XY (Wu,
Xiaoying); Wang, H (Wang, Huan) 来源出版物: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 页:
1-10 DOI: 10.1155/2011/207034 出版年: 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 26 摘要: This study was to determine the impact of adjunctive Buchang Naoxintong Jiaonang (BNJ)
to clopidogrel on volunteers with the CYP2C19*2 gene mutation accompanied with qi deficiency
and blood stasis (QDBS) constitution. Eighteen males with QDBS constitution were selected, who
were 6 CYP2C19*1/*1, 6 CYP2C19*1/*2, and 6 CYP2C19*2/*2, and signed informed consent.
Results showed that the maximal platelet aggregation (Agg(max)) and 5 min aggregation
(Agg(late)) with 5-mu mol/L ADP in three different CYP2C19*2 genotypes were significantly
decreased after any drug therapy compared with corresponding baseline measurements (all values
P < .05). But percent inhibitions of Agg(max) and Agg(late) (IPAs) in CYP2C19*2/*2 genotype at
4 hours, 24 hours, 3 days, and 7 days after clopidogrel administration were all the lowest among
three CYP2C19*2 genotypes (P < .01), and IPAs in CYP2C19*1/*2 genotype were between
CYP2C19*1/*1 and CYP2C19*2/*2. IPAs had no significant difference among three different
CYP2C19*2 genotypes after BNJ or adjunctive BNJ. In addition, changes of CD62P, PAC1, and
sCD40L were similar to changes of ADP-induced platelet aggregation in three different
CYP2C19*2 genotypes. Conclusion was that adjunctive BNJ to clopidogrel can enhance the
antiplatelet effect in volunteers with the CYP2C19*2 gene mutation. 入藏号: WOS:000293395700001 语种: English 文献类型: Article
KeyWords Plus: PERCUTANEOUS CORONARY INTERVENTION; HEART-DISEASE;
THERAPY; POLYMORPHISMS; AGGREGATION; ASSOCIATION; INHIBITION;
EFFICACY; ASPIRIN; STENTS 地址: [Chen, Hui; Yu, Guangwei; Wu, Xiaoying; Wang, Huan] Fujian Med Univ, Dept Internal
Med, Prov Clin Coll, Fujian Prov Cardiovasc Dis Inst, Fuzhou 350001, Fujian, Peoples R China
[Chen, Hui] Fujian Univ Tradit Chinese Med, Clin Discipline Chinese & Western Integrat Med,
Fuzhou 350108, Peoples R China
[Sun, Hong] Fujian Prov Hosp, Dept Pharm, Fuzhou 350001, Peoples R China 通讯作者地址: Chen, H (通讯作者),Fujian Med Univ, Dept Internal Med, Prov Clin Coll, Fujian
Prov Cardiovasc Dis Inst, Fuzhou 350001, Fujian, Peoples R China 电子邮件地址: [email protected] 出版商: HINDAWI PUBLISHING CORPORATION 出版商地址: 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
Web of Science 分类: Integrative & Complementary Medicine 学科类别: Integrative & Complementary Medicine
IDS 号: 800VM
ISSN: 1741-427X
29 字符的来源出版物名称缩写: EVID-BASED COMPL ALT
ISO 来源出版物缩写: Evid.-based Complement Altern. Med. 来源出版物页码计数: 10 基金资助致谢: 基金资助机构 授权号
Ministry of Health of the People's Republic of China WKJ 2008-2-59
Chinese Medical Association of Clinical Medicine Scientific Research 09010150170
This work was supported by the Ministry of Health of the People's Republic of China of Fujian
Province Health Education Union Scientific Grants (WKJ 2008-2-59) and Chinese Medical
Association of Clinical Medicine Scientific Research Special-Purpose Grants (09010150170).
第 71 条,共 86 条 标题: 5-(4-Hydroxy-3-methoxybenzyl)-1,3-thiazolidine-2,4-dione monohydrate 作者: Xiong, LY (Xiong, Li-Yan); Wang, TF (Wang, Ting-Fang); Zheng, LP (Zheng, Li-Ping);
Zhang, CA (Zhang, Chuan); Wang, FC (Wang, Feng-Chun) 来源 出版物 : ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS
ONLINE 卷: 67 页: O16-U1454 DOI: 10.1107/S1600536810049895 子辑: Part 1 出版年:
JAN 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 9 摘要 : In the title compound, C(11)H(11)NO(4)S center dot H(2)O, the five-membered
thiazolidine ring is nearly planar, with a maximum deviation of 0.010 (2) angstrom. The dihedral
angle between the thiazolidine and benzene rings is 49.16 (9)degrees. Intermolecular O-H center
dot center dot center dot O and N-H center dot center dot center dot O hydrogen bonding is
present in the crystal structure. 入藏号: WOS:000285628900120 语种: English 文献类型: Article 地址: [Xiong, Li-Yan; Zhang, Chuan] Mil Med Coll 2, Sch Pharm, New Drug Res Ctr, Shanghai
200433, Peoples R China
[Wang, Ting-Fang; Zheng, Li-Ping] Fujian Univ Tradit Chinese Med, Sch Pharm, Fuzhou 350108,
Peoples R China
[Wang, Feng-Chun] Gen Hosp Beijing Mil Command, Dept Med, Beijing 100700, Peoples R
China 通讯作者地址: Zhang, CA (通讯作者),Mil Med Coll 2, Sch Pharm, New Drug Res Ctr, Shanghai
200433, Peoples R China 电子邮件地址: [email protected]
出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Web of Science 分类: Crystallography 学科类别: Crystallography
IDS 号: 698XQ
ISSN: 1600-5368
29 字符的来源出版物名称缩写: ACTA CRYSTALLOGR E
ISO 来源出版物缩写: Acta Crystallogr. Sect. E.-Struct Rep. Online 来源出版物页码计数: 9 基金资助致谢: 基金资助机构 授权号
Science and Technology Commission of Shanghai 08DZ1970802
National Basic Research Program of China 2006CB504100
2009CB521907
This study was supported by the Science and Technology Commission of Shanghai special
purpose for modernization of traditional Chinese medicine in 2008 (No 08DZ1970802) and the
National Basic Research Program of China (No 2006CB504100 and 2009CB521907).
第 72 条,共 86 条 标题 : Ganoderma lucidum Polysaccharides: Immunomodulation and Potential Anti-Tumor
Activities 作者: Xu, ZT (Xu, Zengtao); Chen, XU (Chen, Xiuping); Zhong, ZF (Zhong, Zhangfeng); Chen,
LD (Chen, Lidian); Wang, YT (Wang, Yitao) 来源出版物: AMERICAN JOURNAL OF CHINESE MEDICINE 卷: 39 期: 1 页: 15-27 DOI:
10.1142/S0192415X11008610 出版年: 2011 在 Web of Science 中的被引频次: 13 被引频次合计: 14 引用的参考文献数: 54 摘要: Ganoderma lucidum (G. lucidum), a basidiomycete white rot fungus, has long been
prescribed to prevent and treat various human diseases, particularly in China, Japan, and Korea.
Several classes of bioactive substances have been isolated and identified from G. lucidum, such as
triterpenoids, polysaccharides, nucleosides, sterols, and alkaloids, among others. This paper
examines the potential role of G. lucidum polysaccharide (GLPS) in tumor therapy and the
possible mechanisms involved. Both in vitro and in vivo studies suggested that the anti-tumor
activities of GLPS are mediated by its immunomodulatory, anti-angiogenic, and cytotoxic effects.
GLPS affects immune cells and immune-related cells including B lymphocytes, T lymphocytes,
dendritic cells, macrophages, and natural killer cells. In addition, recent data also suggest that
GLPS suppresses tumorigenesis or inhibits tumor growth through direct cytotoxic effect and
anti-angiogenic actions. However, many questions still need to be answered before both G.
lucidum and GLPS can be widely accepted and used as anti-tumor agents. 入藏号: WOS:000287004800002 语种: English 文献类型: Article 作者关键词: Ganoderma lucidum; Polysaccharides; Immunomodulation; Anti-Angiogenesis;
Anti-Proliferation
KeyWords Plus: ANTI-ANGIOGENIC ACTIVITY; DENDRITIC CELLS; T-LYMPHOCYTES;
CANCER-IMMUNOTHERAPY; IMMUNE FUNCTIONS; LUNG-CANCER;
MACROPHAGES; MECHANISMS; ACTIVATION; EXTRACT 地址: [Xu, Zengtao; Chen, Lidian] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou,
Peoples R China
[Xu, Zengtao; Chen, Xiuping; Zhong, Zhangfeng; Wang, Yitao] Univ Macau, Inst Chinese Med
Sci, Macao, Peoples R China 通讯作者地址: Chen, LD (通讯作者),Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou,
Peoples R China 电子邮件地址: [email protected] 出版商: WORLD SCIENTIFIC PUBL CO PTE LTD 出版商地址: 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
Web of Science 分类: Integrative & Complementary Medicine; Medicine, General & Internal 学科类别: Integrative & Complementary Medicine; General & Internal Medicine
IDS 号: 716WS
ISSN: 0192-415X
29 字符的来源出版物名称缩写: AM J CHINESE MED
ISO 来源出版物缩写: Am. J. Chin. Med. 来源出版物页码计数: 13 基金资助致谢: 基金资助机构 授权号
Macao Science and Technology Development Fund 029/2007/A2
University of Macau UL016A/09-Y2/CMS/WYT01/ICMS
This study was supported by the Macao Science and Technology Development Fund
(029/2007/A2) and Research Fund of the University of Macau
(UL016A/09-Y2/CMS/WYT01/ICMS).
第 73 条,共 86 条 标题: Corydalis yanhusuo WT Wang Extract Inhibits MCF-7 Cell Proliferation by Inducing Cell
Cycle G2/M Arrest
作者: Xu, ZT (Xu, Zengtao); Chen, XP (Chen, Xiuping); Zhang, QW (Zhang, Qingwen); Chen,
LDA (Chen, Lidian); Wang, YT (Wang, Yitao) 来源出版物 : AMERICAN JOURNAL OF CHINESE MEDICINE 卷 : 39 期 : 3 页 :
579-586 DOI: 10.1142/S0192415X11009044 出版年: 2011 在 Web of Science 中的被引频次: 2 被引频次合计: 2 引用的参考文献数: 21 摘要: Corydalis yanhusuo W. T. Wang (YHS) is a traditional Chinese herb widely prescribed for
promoting blood circulation, reinforcing vital energy and alleviating pain. Our previous studies
showed that an ethanol extract of YHS inhibits metastasis of breast cancer cells in vitro. In the
present study, the anti-proliferative effect of the extract was determined by MTT assay and the
LDH release was measured with a commercial kit. Intracellular reactive oxygen species (ROS)
production and mitochondrial membrane potential (Delta Psi m) were monitored by
CM-H(2)DCF-DA and JC-1 staining, respectively. Cell cycle was analyzed with propidium iodide
(PI) staining by flow cytometry and protein expressions were measured by Western blotting. The
YHS extract significantly inhibited MCF-7 cell proliferation in a dose-dependent manner.
Significant increase of ROS formation and decrease of Delta Psi m were observed. Furthermore, it
induced MCF-7 cell cycle arrest at the G2/M phases. In addition, the p-cdc-2/cdc-2 protein
expression ratio was increased while Rb and p21 protein expressions were decreased.
The YHS extract inhibited MCF-7 proliferation by inducing G2/M cell cycle arrest, which might
be mediated by inducing ROS formation, decreasing Delta Psi m and regulating cell cycle related
protein expressions. 入藏号: WOS:000290857500013 语种: English 文献类型: Article 作者关键词: Corydalis yanhusuo WT Wang Extract; Proliferation; Reactive Oxygen Species;
Mitochondrial Membrane Potential; Cell Cycle Arrest
KeyWords Plus: METHANOLIC EXTRACT; EPITHELIAL-CELLS; APOPTOSIS; TUBER;
CDC2; PATHWAY; RATS 地址: [Chen, Lidian] Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou, Peoples R China
[Xu, Zengtao; Chen, Xiuping; Zhang, Qingwen; Wang, Yitao] Univ Macau, Inst Chinese Med Sci,
Macao, Peoples R China 通讯作者地址: Chen, LD (通讯作者),Fujian Univ Tradit Chinese Med, Dept Pharm, Fuzhou,
Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: WORLD SCIENTIFIC PUBL CO PTE LTD 出版商地址: 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
Web of Science 分类: Integrative & Complementary Medicine; Medicine, General & Internal 学科类别: Integrative & Complementary Medicine; General & Internal Medicine
IDS 号: 767LG
ISSN: 0192-415X
29 字符的来源出版物名称缩写: AM J CHINESE MED
ISO 来源出版物缩写: Am. J. Chin. Med. 来源出版物页码计数: 8 基金资助致谢: 基金资助机构 授权号
Macao Science and Technology Development Fund 029/2007/A2
University of Macau UL016/09-Y2/CMS/WYT01/ICMS
Fujian University of Traditional Chinese Medicine
This study was supported by the Macao Science and Technology Development Fund
(029/2007/A2) and Research Fund of University of Macau (UL016/09-Y2/CMS/WYT01/ICMS).
Mr. Zengtao Xu was supported by scholarship kindly provided by Fujian University of Traditional
Chinese Medicine.
第 74 条,共 86 条 标题: Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic
lupus erythematosus in Chinese population 作者: Liao, LH (Liao, Ling-hong); Zhang, H (Zhang, Hao); Lai, MP (Lai, Man-Po); Chen, SL
(Chen, Shun-Le); Wu, M (Wu, Madeline); Shen, N (Shen, Nan) 来源出版物 : ARTHRITIS RESEARCH & THERAPY 卷 : 13 期 : 1 文献号 : R11 DOI:
10.1186/ar3232 出版年: 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 54 摘要: Introduction: Cytochrome P-450 2E1 (CYP2E1) is an important member of the CYP
superfamily, which is involved in the metabolism and activation of many low molecular weight
toxic compounds. We tried to investigate the possible association of CYP2E1 tag single nucleotide
polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) in a Chinese
Han population.
Methods: The coding and flanking regions of the CYP2E1 gene were scanned for polymorphisms
and tag SNPs were selected. A two-stage case-control study was performed to genotype a total of
876 SLE patients and 680 geographically matched healthy controls (265 cases and 288 controls in
stage I and 611 cases and 392 controls in stage II). SLE associations of alleles, genotypes and
haplotypes were tested by age and sex adjusted logistic regression. The gene transcription
quantitation was carried out for peripheral blood mononuclear cell (PBMC) samples from 120
healthy controls.
Results: Tag SNP rs2480256 was found significantly associated with SLE in both stages of the
study. The "A" allele was associated with slightly higher risk (odds ratio (OR) = 1.165, 95%
confidence interval (CI) 1.073 to 1.265, P = 2.75E-4) and "A/A" genotype carriers were with even
higher SLE risk (OR = 1.464 95% CI 1.259 to 1.702, P = 7.48E-7). When combined with another
tag SNP rs8192772, we identified haplotype "rs8192772-rs2480256/TA" over presented in SLE
patients (OR 1.407, 95% CI 1.182 to 1.675, P = 0.0001) and haplotype "TG" over presented in the
controls (OR 0.771, 95% CI 0.667 to 0.890, P = 0.0004). The gene transcription quantitation
analysis further proved the dominant effect of rs2480256 as the "A/A" genotype showed highest
transcription.
Conclusions: Our results suggest the involvement of CYP2E1 as a susceptibility gene for SLE in
the Chinese population. 入藏号: WOS:000289523500022 语种: English 文献类型: Article
KeyWords Plus: GENOME-WIDE ASSOCIATION; SIB-PAIR FAMILIES;
T-CELL-ACTIVATION; LINKAGE DISEQUILIBRIUM; AUTOIMMU NE-RESPONSE;
SUSCEPTIBILITY GENES; TRICHLOROETHYLENE; SCAN; CYTOCHROME-P450;
VARIANTS 地址: [Chen, Shun-Le; Shen, Nan] Chinese Acad Sci, Joint Mol Rheumatol Lab, Inst Hlth Sci,
Shanghai 200001, Peoples R China
[Liao, Ling-hong] Fujian Univ Tradit Chinese Med, Res Base TCM Syndrom, Fuzhou 350108,
Peoples R China
[Zhang, Hao; Lai, Man-Po; Wu, Madeline] Hong Kong Univ Sci & Technol, Dept Biol, Hong
Kong, Hong Kong, Peoples R China
[Zhang, Hao; Lai, Man-Po; Wu, Madeline] Hong Kong Univ Sci & Technol, Ctr Canc Res, Hong
Kong, Hong Kong, Peoples R China
[Chen, Shun-Le; Shen, Nan] Chinese Acad Sci, Shanghai Ren Ji Hosp, Shanghai Inst Biol Sci,
Shanghai 200001, Peoples R China
[Chen, Shun-Le; Shen, Nan] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200001, Peoples R
China 通讯作者地址: Shen, N (通讯作者),Chinese Acad Sci, Joint Mol Rheumatol Lab, Inst Hlth Sci,
145 Shan Dong Middle Rd, Shanghai 200001, Peoples R China 电子邮件地址: [email protected] 出版商: BIOMED CENTRAL LTD 出版商地址: 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
Web of Science 分类: Rheumatology 学科类别: Rheumatology
IDS 号: 750DA
ISSN: 1478-6354
29 字符的来源出版物名称缩写: ARTHRITIS RES THER
ISO 来源出版物缩写: Arthritis Res. Ther. 来源出版物页码计数: 9 基金资助致谢:
基金资助机构 授权号
Fujian Provincial Department of Science Technology 2010J05071
RGC 471 HKUST6117/01M
HKUST472 CMI03/04.SC03
Mochtar Riady Institute for 473 nanotechnology 06/07.SC01
We acknowledge the financial support of Grant 2010J05071 from Fujian Provincial Department of
Science & Technology, 471 HKUST6117/01M from RGC, Grant CMI03/04.SC03 from
HKUST472 and Grant UPHMSGF 06/07.SC01 from Mochtar Riady Institute for 473
nanotechnology.
第 75 条,共 86 条 标题: Design of a DNA electronic logic gate (INHIBIT gate) with an assaying application for Ag+
and cysteine 作者: Zhu, X (Zhu, Xi); Xu, HF (Xu, Huifeng); Gao, XY (Gao, Xiaoyao); Li, XH (Li, Xianghui);
Liu, QD (Liu, Qida); Lin, ZY (Lin, Zhenyu); Qiu, B (Qiu, Bin); Chen, GN (Chen, Guonan) 来源出版物 : CHEMICAL COMMUNICATIONS 卷 : 47 期 : 32 页 : 9080-9082 DOI:
10.1039/c1cc12734a 出版年: 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 40 摘要: A DNA electronic logic gate (INHIBIT gate) with good selectivity and reversibility is
developed based on using Ag+ and Cys as inputs and current signal as output. 入藏号: WOS:000293346700019 语种: English 文献类型: Article
KeyWords Plus: BASE-PAIRS; COLORIMETRIC DETECTION; GOLD NANOPARTICLES;
HG-II; MERCURY(II); CIRCUITS; IONS; OPERATIONS; COMPLEXES; DNAZYMES 地址: [Zhu, Xi; Gao, Xiaoyao; Li, Xianghui; Lin, Zhenyu; Qiu, Bin; Chen, Guonan] Fuzhou Univ,
Dept Chem, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Minist Educ Key Lab Anal &
Detect Food Safety, Fuzhou 350002, Fujian, Peoples R China
[Xu, Huifeng] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Fujian,
Peoples R China
[Liu, Qida] Xi An Jiao Tong Univ, MOE Key Lab Strength & Vibrat, Xian 710049, Peoples R
China 通讯作者地址: Lin, ZY (通讯作者),Fuzhou Univ, Dept Chem, Fujian Prov Key Lab Anal &
Detect Technol Food Sa, Minist Educ Key Lab Anal & Detect Food Safety, Fuzhou 350002,
Fujian, Peoples R China 电子邮件地址: [email protected]; [email protected]
出版商: ROYAL SOC CHEMISTRY 出版商地址: THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE
CB4 0WF, CAMBS, ENGLAND
Web of Science 分类: Chemistry, Multidisciplinary 学科类别: Chemistry
IDS 号: 800GB
ISSN: 1359-7345
29 字符的来源出版物名称缩写: CHEM COMMUN
ISO 来源出版物缩写: Chem. Commun. 来源出版物页码计数: 3 基金资助致谢: 基金资助机构 授权号
NSFC
40875087
20735002
41076059
20975023
National Basic Research Program of China 2010CB732403
Education Department of Fujian Province XSJRC2007-03
JA09116
National Science Foundation of Fujian Province 2009J01023
The authors gratefully acknowledge the financial support of the NSFC (40875087, 20735002,
41076059 and 20975023), the National Basic Research Program of China (No. 2010CB732403),
Education Department of Fujian Province (XSJRC2007-03, JA09116) and National Science
Foundation of Fujian Province (2009J01023).
第 76 条,共 86 条 标题: A simple "molecular beacon"-based fluorescent sensing strategy for sensitive and selective
detection of mercury (II) 作者: Xu, HF (Xu, Huifeng); Zhu, X (Zhu, Xi); Ye, HZ (Ye, Hongzhi); Yu, LS (Yu, Lishuang);
Liu, XX (Liu, Xianxiang); Chen, GN (Chen, Guonan) 来源出版物 : CHEMICAL COMMUNICATIONS 卷 : 47 期 : 44 页 : 12158-12160 DOI:
10.1039/c1cc14265h 出版年: 2011 在 Web of Science 中的被引频次: 3 被引频次合计: 3 引用的参考文献数: 23 摘要: A novel fluorescent sensor for the detection of Hg(2+) in aqueous media was developed.
The method takes advantages of the highly selective thymine-Hg(2+)-thymine coordination and
the sensitive "signal-on" structure-switching molecular beacon. 入藏号: WOS:000296342800037 语种: English 文献类型: Article
KeyWords Plus: COLORIMETRIC DETECTION; ION HG2+; GOLD NANOPARTICLES;
AQUEOUS-SOLUTION; DNA; SENSOR; MEDIA 地址: [Xu, Huifeng; Ye, Hongzhi; Yu, Lishuang; Liu, Xianxiang] Fujian Univ Tradit Chinese
Med, Acad Integrat Med, Fuzhou, Fujian, Peoples R China
[Xu, Huifeng; Zhu, Xi; Yu, Lishuang; Chen, Guonan] Fuzhou Univ, Dept Chem, Minist Educ, Key
Lab Anal & Detect Food Safety,Fujian Prov Key, Fuzhou 350002, Fujian, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med,
Fuzhou, Fujian, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: ROYAL SOC CHEMISTRY 出版商地址: THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE
CB4 0WF, CAMBS, ENGLAND
Web of Science 分类: Chemistry, Multidisciplinary 学科类别: Chemistry
IDS 号: 839CR
ISSN: 1359-7345
29 字符的来源出版物名称缩写: CHEM COMMUN
ISO 来源出版物缩写: Chem. Commun. 来源出版物页码计数: 3 基金资助致谢: 基金资助机构 授权号
NSFC
20735002
41076059
20877019
Key Foundation of Education Department of Fujian Province JK2009016
Developmental Fund of Chen Keji Integrative Medicine CKJ2010022
This project was financially supported by the NSFC (20735002, 41076059, 20877019), the Key
Foundation of Education Department of Fujian Province (JK2009016) and the Developmental
Fund of Chen Keji Integrative Medicine (Grant No.CKJ2010022).
第 77 条,共 86 条 标题: Effect of Aike Mixture (sic) on the Inflammatory Infiltration in Patients with Chronic
Prostatitis Type III A
作者: Zhang, MJ (Zhang Min-jian); Weng, JF (Weng Jian-fei); Shi, YL (Shi Ya-lei); Cheng, WJ
(Cheng Wan-Jun); Ruan, XJ (Ruan Xiao-jun); Zhang, QY (Zhang Qiu-yong) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 1 页 :
26-30 DOI: 10.1007/s11655-011-0620-7 出版年: JAN 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 10 摘要: Objective: To observe the effect of Aike Mixture ((sic), AKM) on prostatic inflammatory
infiltration in patients with chronic prostatitis type III A (III A-CP/CPPS) and evaluate its
anti-inflammatory action. Methods: A total of 60 patients with III A-CP/CPPS suitable to
operation and differentiated as Chinese medicine Gan (sic)-qi stagnancy syndrome type were
selected. They were assigned with the random number table to two groups equally. Before
operation, the patients in the treated group were administered with Proscar combined with AKM,
but those in the control group treated with Proscar only. Suprapubic transvesical prostatectomy
was performed two weeks later, and prostatic pathological examination was conducted. Results:
Grading of inflammatory cell infiltration showed that the mean grade in the treated group was 0.78
+/- 0.90 grades, which was sihnificantly lower than that in the control group 1.68 +/- 0.87 grades
(P<0.05). However, the two groups were not different in the grades of fibroblast proliferation
(1.50 +/- 0.70 grades vs 1.62 +/- 0.87 grades, P>0.05). Conclusion: AKM could suppress the
inflammatory cell infiltration, be an effective and safe remedy for the treatment of IIIA-CP/CPPS
of Gan-qi stagnancy syndrome type, and worthy for spreading in clinical use. 入藏号: WOS:000286121200005 语种: English 文献类型: Article 作者关键词: Aike Mixture; Chinese medicine; chronic prostatitis; pathology; inflammatory
infiltration 地址: [Zhang Min-jian; Shi Ya-lei; Cheng Wan-Jun; Ruan Xiao-jun; Zhang Qiu-yong] Fujian Coll
Tradit Chinese Med, Peoples Hosp, Fuzhou 350004, Peoples R China
[Weng Jian-fei] Second Fujian Prov Peoples Hosp, Fuzhou 350004, Peoples R China 通讯作者地址: Zhang, MJ (通讯作者),Fujian Coll Tradit Chinese Med, Peoples Hosp, Fuzhou
350004, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA
Web of Science 分类: Integrative & Complementary Medicine 学科类别: Integrative & Complementary Medicine
IDS 号: 705ID
ISSN: 1672-0415
29 字符的来源出版物名称缩写: CHIN J INTEGR MED
ISO 来源出版物缩写: Chin. J. Integr. Med.
来源出版物页码计数: 5 基金资助致谢: 基金资助机构 授权号
Fujian Provincial Fund of Natural Sciences C0440014
Supported by the Fujian Provincial Fund of Natural Sciences (No. C0440014)
第 78 条,共 86 条 标题: Clinical Practice Guideline of Traditional Medicine for Primary Osteoporosis 作者: Xie, YM (Xie Yan-ming); Yuwen, Y (Yuwen Ya); Dong, FH (Dong Fu-hui); Sun, SC (Sun
Shu-chun); Wang, HM (Wang He-ming); Liu, QS (Liu Qing-si); Hua, ZJ (Hua Zhong-jian); Ma,
LX (Ma Liang-xiao); Liao, X (Liao Xing); Xu, GQ (Xu Gui-qin); Zhi, YJ (Zhi Ying-jie); Niu, LF
(Niu Lu-fang); Wu, CS (Wu Chang-sheng) 来源出版物 : CHINESE JOURNAL OF INTEGRATIVE MEDICINE 卷 : 17 期 : 1 页 :
52-63 DOI: 10.1007/s11655-011-0613-6 出版年: JAN 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 90 入藏号: WOS:000286121200010 语种: English 文献类型: Article
KeyWords Plus: PERCUTANEOUS VERTEBROPLASTY; POSTMENOPAUSAL WOMEN;
METAANALYSIS; FRACTURES; QUALITY; HEALTH; FALLS 地址: [Xie Yan-ming; Yuwen Ya; Liao Xing; Xu Gui-qin; Zhi Ying-jie; Niu Lu-fang; Wu
Chang-sheng] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R
China
[Dong Fu-hui; Sun Shu-chun] China Acad Chinese Med Sci, Wangjing Hosp, Beijing 100102,
Peoples R China
[Wang He-ming] Fujian Univ Chinese Med, Fuzhou 350108, Peoples R China
[Liu Qing-si] Guangzhou Univ Tradit Chinese Med, Orthoped Hosp, Guangzhou 510405,
Guangdong, Peoples R China
[Hua Zhong-jian] China Tradit Chinese Med Publishing House, Beijing 100013, Peoples R China
[Ma Liang-xiao] Beijing Univ Chinese Med, Beijing 100029, Peoples R China 通讯作者地址: Yuwen, Y (通讯作者),China Acad Chinese Med Sci, Inst Basic Res Clin Med,
Beijing 100700, Peoples R China 电子邮件地址: [email protected] 出版商: SPRINGER 出版商地址: 233 SPRING ST, NEW YORK, NY 10013 USA
Web of Science 分类: Integrative & Complementary Medicine
学科类别: Integrative & Complementary Medicine
IDS 号: 705ID
ISSN: 1672-0415
29 字符的来源出版物名称缩写: CHIN J INTEGR MED
ISO 来源出版物缩写: Chin. J. Integr. Med. 来源出版物页码计数: 12 基金资助致谢: 基金资助机构 授权号
West-Pacific Region of World Health Organization WP/2006/CHN/EDM/3.2/001
Supported by a granted from West-Pacific Region of World Health Organization (No.
WP/2006/CHN/EDM/3.2/001)
第 79 条,共 86 条 标题: Association study of interleukin-12A gene polymorphisms with Graves' disease in two
Chinese populations 作者: Guo, T (Guo, Ting); Yang, S (Yang, Shuyu); Liu, N (Liu, Nan); Wang, S (Wang, Shu); Cui,
B (Cui, Bin); Ning, GA (Ning, Guang) 来 源 出 版 物 : CLINICAL ENDOCRINOLOGY 卷 : 74 期 : 1 页 : 125-129 DOI:
10.1111/j.1365-2265.2010.03905.x 出版年: JAN 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 1 引用的参考文献数: 33 摘要: Objective Graves' disease (GD) is a common autoimmune disorder and genetic and
environmental factors contributing to its aetiology. The pro-inflammatory cytokine interleukin-12
(IL-12) is believed to be critically involved in the pathogenesis of GD. This study aims to
elucidate the effect of IL-12A gene polymorphisms on GD.
Design and methods A case-control association study of five tag single nucleotide polymorphisms
(SNPs) (rs2243115, rs2243123, rs583911, rs568408 and rs2243143) within the IL-12A gene was
performed in two independent Chinese cohorts. A pilot cohort conducted in Shanghai consisted of
701 patients and 686 controls and a replicate cohort in Xiamen Island included 378 patients and
312 controls. The five SNPs were genotyped by the SNPstream Genotyping Systems and Taqman
PCR method.
Results Polymorphism of rs568408, located at the 3'-UTRregion, was found to have a significant
association with GD in both the cohorts (P(allele) = 2.96 x 10(-7) and Pallele = 0 013 for Shanghai
and Xiamen Island cohorts, respectively). Haplotype analysis showed that the haplotype of the
five SNPs (TTAAG) was associated with a significant risk of GD in both the cohorts (OR = 2.04
and OR = 1.70 for Shanghai and Xiamen Island cohorts, respectively).
Conclusion Our results have established an association between IL-12A polymorphism and GD
susceptibility in the Chinese population.
入藏号: WOS:000285355500017 语种: English 文献类型: Article
KeyWords Plus: SUSCEPTIBILITY; VARIANTS; IL-12; MECHANISMS; CYTOKINES;
MULTIPLE; REGION; IL12B; GAMMA; RISK 地址: [Guo, Ting; Wang, Shu; Cui, Bin; Ning, Guang] Chinese Acad Sci, Shanghai Inst Biol Sci,
Inst Hlth Sci, Lab Endocrine & Metab Dis, Shanghai, Peoples R China
[Guo, Ting; Wang, Shu; Cui, Bin; Ning, Guang] Shanghai Jiao Tong Univ, Sch Med, Shanghai
200030, Peoples R China
[Yang, Shuyu] Fujian Univ Tradit Chinese Med, Fujian Acad Integrat Med, Univ Town, Fujian,
Peoples R China
[Liu, Nan; Wang, Shu; Cui, Bin; Ning, Guang] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp,
Shanghai Clin Ctr Endocrine & Metab Dis,Shanghai, Shanghai 200030, Peoples R China 通讯作者地址: Ning, GA (通讯作者),197 Ruijin Er Lu, Shanghai 200025, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL PUBLISHING, INC 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Web of Science 分类: Endocrinology & Metabolism 学科类别: Endocrinology & Metabolism
IDS 号: 695FH
ISSN: 0300-0664
29 字符的来源出版物名称缩写: CLIN ENDOCRINOL
ISO 来源出版物缩写: Clin. Endocrinol. 来源出版物页码计数: 5 基金资助致谢: 基金资助机构 授权号
Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Public
Health 1994DP131044
National Natural Science Foundation of China 81070670
The present study would not have been possible without the participation of the patients and
healthy volunteers. The study was partly supported by the Key Laboratory for Endocrine and
Metabolic Diseases of Ministry of Public Health (No. 1994DP131044) and National Natural
Science Foundation of China (No. 81070670).
第 80 条,共 86 条 标题: Electroacupuncture Protected Pyramidal Cells in Hippocampal CA1 Region of Vascular
Dementia Rats by Inhibiting the Expression of P53 and Noxa 作者: Zhu, YZ (Zhu, Yanzhen); Zeng, YJ (Zeng, Yanjun)
来源出版物: CNS NEUROSCIENCE & THERAPEUTICS 卷: 17 期: 6 页: 599-604 DOI:
10.1111/j.1755-5949.2010.00192.x 出版年: 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 15 摘要: Aim: Clinically electroacupuncture (EA) is proved an effective therapy for vascular
dementia (VD), but their mechanisms remain uncertain. The aim of this study was to determine
whether EA protects pyramidal cells from apoptosis in hippocampus of a VD rat model by
inhibiting the expression of p53 and Noxa. Methods: One month after a VD animal model was
established by bilateral occlusion of common carotid arteries, EA treatment was given at Baihui
(DU20), Dazhui (DU14), and Shenshu (BL23). The learning and memory ability was assessed by
Morris water maze. Neuronal apoptosis in hippocampus was evaluated with hematoxylineosin
(HE) staining, and the expression of p53 and Noxa was analyzed by confocal laser scanning
microscope with immunofluorescence staining. Results: Expressions of p53 and Noxa in the EA
group and sham-operated group were less than in the VD model group (P < 0.01), and the
expression of p53 was positively correlated to expression of Noxa in hippocampus of VD rats (r =
0.918, P < 0.01). EA treatment could reduce the amount of apoptotic neurons in hippocampal CA1
area of rats with VD. The average latency in the Morris water maze test was significantly shorter,
and escape strategies improved from edge and random searches to more linear swim pathway in
the EA group compared with the VD model group (P < 0.01). Conclusions: The increasing
expressions of p53 and Noxa play important roles in the pathogenesis of VD. EA improves
learning and memory ability and protects pyramidal cells from apoptosis by blocking expression
of p53 and Noxa in the hippocampal CA1 region of VD rats. These results suggest a novel
mechanism of EA treatment to VD. 入藏号: WOS:000297316900004 语种: English 文献类型: Article 作者关键词: Apoptosis; Electroacupuncture; p53; Noxa; Vascular dementia
KeyWords Plus: CEREBRAL-ISCHEMIA; APOPTOSIS; DEATH; MEDIATOR; PROTEIN;
GENE 地址: [Zeng, Yanjun] Beijing Univ Technol, Biomech & Med Informat Inst, Beijing 100022,
Peoples R China
[Zhu, Yanzhen] Fujian Univ Tradit Chinese Med, Dept Integrat Med, Fuzhou, Fujian Province,
Peoples R China 通讯作者地址: Zeng, YJ (通讯作者),Beijing Univ Technol, Biomech & Med Informat Inst,
Beijing 100022, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Web of Science 分类: Neurosciences; Pharmacology & Pharmacy 学科类别: Neurosciences & Neurology; Pharmacology & Pharmacy
IDS 号: 852AT
ISSN: 1755-5930
29 字符的来源出版物名称缩写: CNS NEUROSCI THER
ISO 来源出版物缩写: CNS Neurosci. Ther. 来源出版物页码计数: 6 基金资助致谢: 基金资助机构 授权号
Fujian Provincial Health Department 2005-2-40
This study was supported by fund for Youth Teacher from Fujian Provincial Health Department,
No. 2005-2-40.
第 81 条,共 86 条 标题 : Determination of the epimerization rate constant of amygdalin by microemulsion
electrokinetic chromatography 作者: Yu, LS (Yu, Lishuang); Ye, HZ (Ye, Hongzhi); Zheng, LL (Zheng, Lili); Chen, LD (Chen,
Lidian); Chu, KD (Chu, Kedan); Liu, XX (Liu, Xianxiang); Xu, XQ (Xu, Xueqin); Chen, GN
(Chen, Guonan) 来 源 出 版 物 : ELECTROPHORESIS 卷 : 32 期 : 2 页 : 218-222 DOI:
10.1002/elps.201000287 出版年: JAN 2011 在 Web of Science 中的被引频次: 2 被引频次合计: 2 引用的参考文献数: 36 摘要 : A new method for separation and determination of amygdalin and its epimer
(neoamygdalin) in the epimerization of amygdalin by MEEKC is proposed. For the chiral
separation of amygdalin and neoamygdalin, a running buffer composed of 80 mM sodium cholate,
5.0% v/v butan-1-ol, 0.5% v/v heptane and 94.5% v/v 30 mM Na(2)B(4)O(7) buffer (pH 9.00) is
proposed. Under optimum conditions, the basic separation of amygdalin and neoamygdalin can be
achieved within 7 min. The calibration curve for amygdalin showed excellent linearity in the
concentration range of 20-1000 mu g/mL with a detection limit of 5.0 mu g/mL (S/N = 3). The
epimerization rate constant of amygdalin in basic microemulsion was first determined by
monitoring the concentration changes of amygdalin, and the epimerization rate constant of
amygdalin was found to be 2 x 10(-3) min(-1) at 25 degrees C under the above optimum
microemulsion conditions. 入藏号: WOS:000287156700003 语种: English 文献类型: Article 作者关键词 : Amygdalin; Electrokinetic chromatography; Epimerization rate constant;
Microemulsion
KeyWords Plus: WATER PARTITION-COEFFICIENTS; CAPILLARY-ELECTROPHORESIS;
LIQUID-CHROMATOGRAPHY; SEPARATION; MICELLAR; OIL; ENANTIOMERIZATION;
SELECTIVITY; CATECHINS; TARTRATE 地址: [Yu, Lishuang; Ye, Hongzhi; Chen, Lidian; Chu, Kedan; Liu, Xianxiang] Fujian Univ Tradit
Chinese Med, Coll Pharm, Fuzhou 350108, Fujian, Peoples R China
[Yu, Lishuang; Zheng, Lili; Xu, Xueqin; Chen, Guonan] Fuzhou Univ, Minist Educ, Key Lab Anal
& Detect Technol Food Safety, Fuzhou 350002, Fujian, Peoples R China
[Yu, Lishuang; Zheng, Lili; Xu, Xueqin; Chen, Guonan] Fuzhou Univ, Dept Chem, Fuzhou
350002, Fujian, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Coll Pharm, Fuzhou
350108, Fujian, Peoples R China 电子邮件地址: [email protected]; [email protected] 出版商: WILEY-V C H VERLAG GMBH 出版商地址: PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY
Web of Science 分类: Biochemical Research Methods; Chemistry, Analytical 学科类别: Biochemistry & Molecular Biology; Chemistry
IDS 号: 718WH
ISSN: 0173-0835
29 字符的来源出版物名称缩写: ELECTROPHORESIS
ISO 来源出版物缩写: Electrophoresis 来源出版物页码计数: 5 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China 20735002
Key Natural Sciences Foundation of Fujian Province, China D0520001
Natural Sciences Foundation of Fujian Province, China 2010J05020
Key Science and Technology Projects of Fujian Province, China 2009YZ0001-1-1
Program for New Century Excellent Talents in Fujian Province
University XSJRC2007-13
Developmental Fund of Chen Keji Integrative Medicine CKJ2007020ZXYJH200710
This project was financially supported by the National Natural Science Foundation of China
(20735002), the Key Natural Sciences Foundation of Fujian Province, China (D0520001), the
Natural Sciences Foundation of Fujian Province, China (2010J05020) and the Key Science and
Technology Projects of Fujian Province, China (2009YZ0001-1-1), the Program for New Century
Excellent Talents in Fujian Province University (XSJRC2007-13), and the Developmental Fund of
Chen Keji Integrative Medicine (CKJ2007020ZXYJH200710).
第 82 条,共 86 条 标题: In vitro antioxidant activities of endophytic fungi isolated from the liverwort Scapania
verrucosa 作者: Zeng, PY (Zeng, P. Y.); Wu, JG (Wu, J. G.); Liao, LM (Liao, L. M.); Chen, TQ (Chen, T.
-Q.); Wu, JZ (Wu, J. Z.); Wong, KH (Wong, K. -H.) 来源出版物: GENETICS AND MOLECULAR RESEARCH 卷: 10 期: 4 页: 3169-3179 DOI:
10.4238/2011.December.20.1 出版年: 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 39 摘要: We investigated in vitro antioxidant activities of 49 endophytic fungi isolated from the
liverwort Scapania verrucosa. Based on morphological and molecular identification, the
endophytic fungi isolated were classified into seven genera (Hypocrea, Penicillium,
Tolypocladium, Chaetomium, Xylaria, Nemania, and Creosphaeria), all belonging to one family
(Xylariaceae). By screening with the 2,2'-azino-di(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS)
decolorization assay, the ethyl acetate extracts of five endophytic fungi (T7, T21, T24, T32, and
T38 strains), which exhibited remarkable Trolox equivalent (TE) antioxidant capacity (ranging
from 997.06 to 1248.10 mu mol TE/g extract), were selected and their antioxidant capacity was
further evaluated by assays for 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging,
hydroxyl radical scavenging, reducing power, and ferrous ion chelating. The ethyl acetate extracts
of two endophytic fungi (T24 and T38) were found to have comparable scavenging abilities on
both DPPH-free radicals (93.9 and 88.7%, respectively, at 50 mu g/mL) and hydroxyl radicals
(97.1 and 89.4%, respectively, at 2 mg/mL) when compared with those of the positive controls
(ascorbic acid and butylated hydroxytoluene, respectively). Although their reducing powers were
similar to that of butylated hydroxytoluene, as indicated by absorbance (0.35 and 0.30 at 50 mu
g/mL, respectively), only the T38 strain's ethyl acetate extract showed ferrous ion chelating ability
(92.9% at 1 mg/mL) comparable to that of the EDTA-2Na control. These endophytic fungi in S.
verrucosa are a potential novel source of natural antioxidants. 入藏号: WOS:000300617600090 语种: English 文献类型: Article 作者关键词: Endophytic fungi; Antioxidant activity; ABTS; DPPH; Scavenging ability; Ferrous
ion chelating ability
KeyWords Plus: RADICAL SCAVENGING ACTIVITY; PESTALOTIOPSIS-MICROSPORA;
EXTRACTS; METABOLITES; ANTIFUNGAL; FOODS 地址: [Zeng, P. Y.; Wu, J. G.; Liao, L. M.; Wu, J. Z.] Fujian Univ Tradit Chinese Med, Acad
Integrat Med, Fuzhou, Peoples R China
[Chen, T. -Q.] Fujian Acad Agr Sci, Inst Edible & Med Fungi, Fuzhou, Peoples R China
[Wong, K. -H.] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong
Kong, Peoples R China 通讯作者地址: Wu, JZ (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou,
Peoples R China 电子邮件地址: [email protected] 出版商: FUNPEC-EDITORA 出版商地址: RUA HUDSON 655, JARDIM CANADA, RIBEIRAO PRETO, SP, BRAZIL
Web of Science 分类: Biochemistry & Molecular Biology; Genetics & Heredity 学科类别: Biochemistry & Molecular Biology; Genetics & Heredity
IDS 号: 897CA
ISSN: 1676-5680
29 字符的来源出版物名称缩写: GENET MOL RES
ISO 来源出版物缩写: Genet. Mol. Res. 来源出版物页码计数: 11 基金资助致谢: 基金资助机构 授权号
Natural Science Foundation of Fujian Province 2008J0097
Fujian Provincial Universities for Haixi Development
Research supported by the Natural Science Foundation of Fujian Province (#2008J0097) and the
Fujian Provincial Universities for Haixi Development (Grant #5). We thank Dr. Lu Ping Qin and
Lei Guo (Second Military Medical University, Shanghai, P. R. China) for their assistance in
identifying the endophytic fungi.
第 83 条,共 86 条 标题: In vitro study of inhibitory millimeter wave treatment effects on the TNF-alpha-induced
NF-kappa B signal transduction pathway 作者: Li, XH (Li, Xihai); Wu, GW (Wu, Guangwen); Wu, MX (Wu, Mingxia); Chen, WL (Chen,
Wenlie); Liu, XX (Liu, Xianxiang) 来源出版物: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 卷: 27 期: 1 页:
71-78 DOI: 10.3892/ijmm.2010.549 出版年: JAN 2011 在 Web of Science 中的被引频次: 3 被引频次合计: 4 引用的参考文献数: 25 摘要: Abnormal activation of the nuclear factor-kappa B (NF-kappa B) in chondrocytes initiates
the transcription of inflammatory mediators, promotes their generation and release, and amplifies
initial inflammatory signals. This results in the release of chondral matrix-degrading enzymes and
accelerates the degeneration of articular cartilage. As a non-pharmaceutical and non-invasive
physical therapy regimen, millimeter wave treatment has been successfully used for the treatment
of osteoarthritis. In this study, chondrocytes were derived from the cartilages of knee joints of
4-week-old male Sprague-Dawley rats and were mechanically digested by collagenase type II
treatment for further culture in vitro. The third-passage chondrocytes were stained with toluidine
blue and treated with a gradient of tumor necrosis factor-a (TNF-alpha) for various times.
Chondrocytic activity was measured by MTT assay, and the apoptotic rate of the chondrocytes
was determined with Hocehst 33342 staining to identify effective treatment concentrations and
durations and to establish an apoptosis model for the chondrocytes in response to TNF-a. Using
this model, the chondrocytes were randomly divided to receive millimeter wave treatment for
various times. The apoptotic rate of the chondrocytes was measured by Annexin V-FITC staining
and the protein expression levels of RIP, TAK1, I kappa B kinase (IKK)-beta, I beta B-alpha and
NF-kappa B, were determined by Western blotting. Chondrocytic structure was examined by
transmission electronic microscopy. The apoptotic rates were significantly lower at 4 and 8 h of
treatment than at 0 and 2 h. The expression levels of RIP, TAK1, IKK-B and NF-kappa B were
also significantly lower at 4 and 8 h than at 0 and 2 h, whereas that of I kappa B-alpha was
significantly higher at 4 and 8 h than at 0 and 2 h. Therefore, we can conclude that millimeter
wave treatment can inhibit the activation of the TNF-alpha-mediated NF-kappa B signal
transduction pathway through the down-regulation of RIP, TAK1, IKK-beta and NF-kappa B, and
the up-regulation of I kappa B-alpha, in chondrocytes. 入藏号: WOS:000286293100008 语种: English 文献类型: Article 作者关键词 : osteoarthritis; millimeter wave; chondrocyte; signal transduction; nuclear
factor-kappa B
KeyWords Plus: RHEUMATOID-ARTHRITIS; INFLAMMATORY CYTOKINES; RECEPTOR
ACTIVATOR; SUBCHONDRAL BONE; CHONDROCYTES; EXPRESSION;
OSTEOARTHRITIS; CELLS; DIFFERENTIATION; APOPTOSIS 地址: [Li, Xihai; Wu, Guangwen; Chen, Wenlie; Liu, Xianxiang] Fujian Univ Tradit Chinese
Med, Inst Integrat Med, Fuzhou 350108, Peoples R China
[Wu, Mingxia] Fujian Univ Tradit Chinese Med, Hosp 2, Dept Acupuncture & Moxibust, Fuzhou
350003, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Inst Integrat Med, Fuzhou
350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE
Web of Science 分类: Medicine, Research & Experimental 学科类别: Research & Experimental Medicine
IDS 号: 707NK
ISSN: 1107-3756
29 字符的来源出版物名称缩写: INT J MOL MED
ISO 来源出版物缩写: Int. J. Mol. Med. 来源出版物页码计数: 8 基金资助致谢:
基金资助机构 授权号
Small Invention and Small Program of Fujian Province
Open Fund of Fujian Key Laboratory of Integrative Medicine on Geriatrics 2008J1004-16
This study was supported by the 2008 Small Invention and Small Program of Fujian Province (no.
1) and the Open Fund of Fujian Key Laboratory of Integrative Medicine on Geriatrics (grant no.
2008J1004-16).
第 84 条,共 86 条 标题: Experimental study of low-frequency electroacupuncture-induced differentiation of bone
marrow mesenchymal stem cells into chondrocytes 作者: Wu, GW (Wu, Guangwen); Peng, J (Peng, Jun); Wu, MX (Wu, Mingxia); Li, YR (Li,
Yurong); Huang, YM (Huang, Yunmei); Lin, RH (Lin, Ruhui); Cai, QY (Cai, Qiaoyan); Liu, XX
(Liu, Xianxiang) 来源出版物: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 卷: 27 期: 1 页:
79-86 DOI: 10.3892/ijmm.2010.555 出版年: JAN 2011 在 Web of Science 中的被引频次: 1 被引频次合计: 1 引用的参考文献数: 31 摘要: in the present study, we investigated the effect of low-frequency electroacupuncture (EA) on
the differentiation of bone mesenchymal stem cells (BMSCs) into chondrocytes and the molecular
mechanism involved. We isolated BMSCs from Sprague-Dawley (SD) rat bone marrow.
Third-generation SD rat BMSCs (P3 BMSCs) were harvested and characterized by flow
cytometry with FITC staining. Data indicated that the positive rates of CD90 and CD45 were
98.22 and 1.91%, respectively, indicating the high purity of the BMSCs. The P3 BMSCs were
treated with EA for 15 or 30 min daily for 7 or 14 days. Using optical microscopy and
transmission electron microscopy, we found that EA induced morphological changes in the
BMSCs, displaying typical morphology of early chondrocytes. In addition, we found that the
cytoplasm and extracellular matrices were metachromatically stained by toluidine blue in the
treated cells in a dose-dependent manner, indicating that EA treatment resulted in the expression
of glycosaminoglycan. Furthermore, upon immunohistocyto-chemical staining and Western
blotting, we found that EA treatment significantly and dose-dependently induced expression of
chondrocyte-specific matrix protein type II collagen, which may have been mediated by the
transcription factor Sox9, as the mRNA expression of Sox9 was found to be significantly
increased after EA treatment. Taken together, these results suggest that EA can be employed as a
novel non-drug-inducing method for the differentiation of BMSCs into chondrocytes. 入藏号: WOS:000286293100009 语种: English 文献类型: Article 作者关键词: bone mesenchymal stem cells; low-frequency electroacupuncture; differentiation;
chondrocytes; tissue engineering
KeyWords Plus: II COLLAGEN; UMBILICAL-CORD; STROMAL CELLS; TISSUE; SOX9;
OSTEOARTHRITIS; ACUPUNCTURE; EXPRESSION; MOUSE; CHONDROGENESIS 地址: [Wu, Guangwen; Peng, Jun; Wu, Mingxia; Huang, Yunmei; Lin, Ruhui; Cai, Qiaoyan; Liu,
Xianxiang] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350108, Peoples R
China
[Li, Yurong] Fuzhou Univ, Inst Precis Instruments, Fuzhou 350002, Peoples R China 通讯作者地址: Liu, XX (通讯作者),Fujian Univ Tradit Chinese Med, Acad Integrat Med, 1
Huatuo Rd, Fuzhou 350108, Peoples R China 电子邮件地址: [email protected] 出版商: SPANDIDOS PUBL LTD 出版商地址: POB 18179, ATHENS, 116 10, GREECE
Web of Science 分类: Medicine, Research & Experimental 学科类别: Research & Experimental Medicine
IDS 号: 707NK
ISSN: 1107-3756
29 字符的来源出版物名称缩写: INT J MOL MED
ISO 来源出版物缩写: Int. J. Mol. Med. 来源出版物页码计数: 8 基金资助致谢: 基金资助机构 授权号
Fujian Province Small Creations and Projects
Fujian Provincial Health Department WZZG0601
This research was supported by 2008 Fujian Province Small Creations and Projects (no.1) and Key
Project of Traditional Chinese Medicine of Fujian Provincial Health Department (WZZG0601).
第 85 条,共 86 条 标题: Cognitive Obstacles Against Organ Donation: The Influence of Negative Attitudes, Norms,
and Traditional Beliefs on Chinese People's Intention to Donate Organs after Death 作者: Wu, AMS (Wu, Anise M. S.); Lu, LS (Lu, Lu-Sha) 来源出版物: JOURNAL OF COMMUNITY & APPLIED SOCIAL PSYCHOLOGY 卷: 21 期:
1 页: 87-93 DOI: 10.1002/casp.1054 出版年: JAN-FEB 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 21 摘要: In China, the organ supply is severely insufficient to cover all people on the waiting list for
donated organs, and numerous patients die awaiting transplant. To achieve a better understanding
of cadaveric organ donation in Chinese culture, this study examined 300 Chinese adults, in both
Fujian Province and Macao, regarding attitudes towards organ donation, subjective norms about
organ donation and traditional beliefs about the body and death, examining the influences of these
factors on respondents' donation intentions. Multiple hierarchical regression results suggest that
more negative attitudes, unfavourable norms and traditional beliefs lead to lower donation
intentions. Copyright (C) 2010 John Wiley & Sons, Ltd. 入藏号: WOS:000285310300007 语种: English 文献类型: Article 作者关键词: organ donation; intention; attitudes; norms; beliefs
KeyWords Plus: PLANNED BEHAVIOR; KNOWLEDGE; STUDENTS; DONORS 地址: [Wu, Anise M. S.] Lingnan Univ, Dept Sociol & Social Policy, Hong Kong, Hong Kong,
Peoples R China
[Lu, Lu-Sha] Fujian Univ Tradit Chinese Med, Fujian, Peoples R China 通讯作者地址: Wu, AMS (通讯作者),Lingnan Univ, Dept Sociol & Social Policy, Hong Kong,
Hong Kong, Peoples R China 电子邮件地址: [email protected] 出版商: WILEY-BLACKWELL 出版商地址: COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
Web of Science 分类: Psychology, Social 学科类别: Psychology
IDS 号: 694PO
ISSN: 1052-9284
29 字符的来源出版物名称缩写: J COMMUNITY APPL SOC
ISO 来源出版物缩写: J. Community Appl. Soc. Psychol. 来源出版物页码计数: 7
第 86 条,共 86 条 标题: SERS spectra of a single nasopharyngeal carcinoma cell based on intracellularly grown and
passive uptake Au nanoparticles 作者: Huang, H (Huang, Hao); Chen, WW (Chen, Weiwei); Pan, JJ (Pan, Jianji); Chen, QS (Chen,
Qisong); Feng, SY (Feng, Shangyuan); Yu, Y (Yu, Yun); Chen, YP (Chen, Yanping); Su, Y (Su,
Ying); Chen, R (Chen, Rong) 来源出版物 : SPECTROSCOPY-BIOMEDICAL APPLICATIONS 卷 : 26 期 : 3 页 :
187-194 DOI: 10.3233/SPE-2011-0540 出版年: 2011 在 Web of Science 中的被引频次: 0 被引频次合计: 0 引用的参考文献数: 23 摘要: The intracellularly-grown-Au-nanoparticles (IGAuNs) technique was employed to analyze
the surface-enhanced Raman scattering (SERS) spectra of nasopharyngeal carcinoma cells
(CNE-1 cell line). There are only six obvious Raman bands (718, 1001, 1123, 1336, 1446, 1660
cm(-1)) in the normal Raman spectrum of living CNE-1 cells. However, over twenty SERS
Raman bands have been detected in the SERS spectra of IGAuNs-induced cells, among which five
bands are of the DNA backbone (673, 1097, 1306, 1336 and 1585 cm(-1)). There are four
vibrations of the DNA backbone (1026, 1097, 1336 and 1585 cm-1) in the SERS spectra of living
CNE-1 cells induced by the passive uptake gold nanoparticles (PUAuNS), but one more DNA
backbone and many nucleus Raman peaks appeared in the IGAuNs-induced SERS spectra. Many
Raman peaks in the PUAuNs-induced SERS spectra are stronger than those in the
IGAuNs-induced ones. This study has shown that the PUAuNs technique can achieve stronger
Raman signals, and that the IGAuNs technique can enable the gold element to access to the
nucleus more easily, which could help to obtain more surface-enhanced Raman signals of the
intracellular biochemical molecules. Thus, the two techniques can work together to attain the
Raman spectral information of the cytoplasm and the nucleus in a better way, which might provide
a sensitive method for broad biomedical applications such as intracellular SERS analysis of living
cells. 入藏号: WOS:000299109400005 语种: English 文献类型: Article 作者关键词 : Surface-enhanced Raman scattering (SERS); intracellularly grown gold
nanoparticles (IGAuNs); passively uptaken gold nanoparticles (PUAuNS); nasopharyngeal
carcinoma cell
KeyWords Plus: ENHANCED RAMAN-SPECTROSCOPY; LIVING CELLS; LIVE CELLS;
NANOSENSORS; SCATTERING; TISSUES 地址: [Chen, Weiwei; Feng, Shangyuan; Yu, Yun; Chen, Rong] Fujian Normal Univ, Key Lab
Optoelect Sci & Technol Med, Minist Educ, Fujian Prov Key Lab Photon Technol, Fuzhou
350007, Peoples R China
[Huang, Hao; Chen, Weiwei; Yu, Yun] Fujian Univ Tradit Chinese Med, Coll Integrated Tradit
Chinese & Western Med, Fuzhou, Peoples R China
[Pan, Jianji; Chen, Qisong; Su, Ying] Fujian Prov Canc Hosp, Fuzhou, Peoples R China
[Chen, Yanping] Fujian Prov Tumor Hosp, Fuzhou, Peoples R China 通讯作者地址: Feng, SY (通讯作者),Fujian Normal Univ, Key Lab Optoelect Sci & Technol
Med, Minist Educ, Fujian Prov Key Lab Photon Technol, Fuzhou 350007, Peoples R China 电子邮件地址: [email protected] 出版商: IOS PRESS 出版商地址: NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
Web of Science 分类: Biochemical Research Methods; Spectroscopy 学科类别: Biochemistry & Molecular Biology; Spectroscopy
IDS 号: 876LQ
ISSN: 0712-4813
29 字符的来源出版物名称缩写: SPECTROSC-BIOMED APP
ISO 来源出版物缩写: Spectrosc.-Biomed. Appl.
来源出版物页码计数: 8 基金资助致谢: 基金资助机构 授权号
National Natural Science Foundation of China
11104030
61178090
81101110
Project of Fujian Province
2008J0016
2009J01276
JA11055
Science Foundation of Ministry of Health
United Fujian Provincial Health and Education Project for Tackling the Key
Research WKJ2008-2-046
State Key Laboratory of Physical Chemistry of Solid Surface and Fujian Key
Lab. of Semiconductors and Applications, Xiamen University
The study was supported by the National Natural Science Foundation of China (Nos 11104030,
61178090, 81101110), the Project of Fujian Province (Nos 2008J0016, 2009J01276, JA11055), the
Project of Science Foundation of Ministry of Health and United Fujian Provincial Health and
Education Project for Tackling the Key Research (No. WKJ2008-2-046), and the Project of State
Key Laboratory of Physical Chemistry of Solid Surface and Fujian Key Lab. of Semiconductors
and Applications, Xiamen University. We greatly appreciate all the support of the above
organizations and the assistance from Dr. Haishan Zeng and Dr. Zhiwei Huang.
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