Gabapentin
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Reactions 1480, p20 - 30 Nov 2013 S Gabapentin Highly elevated liver enzymes in a child: case report A male child developed highly elevated liver enzymes during treatment with gabapentin. The child [age not stated] had high-risk neuroblastoma. He underwent immunotherapy with the anti-GD2 monoclonal antibody. Three days prior to each cycle of immunotherapy, he started receiving oral gabapentin [dosage not stated]. The gabapentin was continued until the end of each immunotherapy course. His AST and ALT levels increased to 285 U/L and 312 U/L, respectively, during his first 3 courses [duration of treatment to reaction onset not clearly stated]. Before the start of his fourth course, after 3 days of gabapentin premedication, he had an increase in his AST level to 502 U/L and his ALT level to 500 U/L. Gabapentin was withdrawn. The child’s laboratory values gradually improved. Author comment: "A Naranjo score was calculated to determine a causality-relation. A highly probable relation score between use of gabapentin and high increase in hepatic enzymes was obtained." Bauters T, et al. Highly elevated liver enzymes related to the use of gabapentin in a child treated for high-risk neuroblastoma. Pediatric Blood and Cancer 60 (Suppl. S3): 116, Sep 2013. Available from: URL: http://dx.doi.org/10.1002/pbc.24719 [abstract] - Belgium 803096257 1 Reactions 30 Nov 2013 No. 1480 0114-9954/13/1480-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Transcript of Gabapentin
Reactions 1480, p20 - 30 Nov 2013
SGabapentin
Highly elevated liver enzymes in a child: case reportA male child developed highly elevated liver enzymes during
treatment with gabapentin.The child [age not stated] had high-risk neuroblastoma. He
underwent immunotherapy with the anti-GD2 monoclonalantibody. Three days prior to each cycle of immunotherapy, hestarted receiving oral gabapentin [dosage not stated]. Thegabapentin was continued until the end of eachimmunotherapy course. His AST and ALT levels increased to285 U/L and 312 U/L, respectively, during his first 3 courses[duration of treatment to reaction onset not clearly stated].Before the start of his fourth course, after 3 days of gabapentinpremedication, he had an increase in his AST level to 502 U/Land his ALT level to 500 U/L.
Gabapentin was withdrawn. The child’s laboratory valuesgradually improved.
Author comment: "A Naranjo score was calculated todetermine a causality-relation. A highly probable relationscore between use of gabapentin and high increase in hepaticenzymes was obtained."Bauters T, et al. Highly elevated liver enzymes related to the use of gabapentin ina child treated for high-risk neuroblastoma. Pediatric Blood and Cancer 60 (Suppl.S3): 116, Sep 2013. Available from: URL: http://dx.doi.org/10.1002/pbc.24719[abstract] - Belgium 803096257
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Reactions 30 Nov 2013 No. 14800114-9954/13/1480-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
