Reactions 1480, p20 - 30 Nov 2013

SGabapentin

Highly elevated liver enzymes in a child: case reportA male child developed highly elevated liver enzymes during

treatment with gabapentin.The child [age not stated] had high-risk neuroblastoma. He

underwent immunotherapy with the anti-GD2 monoclonalantibody. Three days prior to each cycle of immunotherapy, hestarted receiving oral gabapentin [dosage not stated]. Thegabapentin was continued until the end of eachimmunotherapy course. His AST and ALT levels increased to285 U/L and 312 U/L, respectively, during his first 3 courses[duration of treatment to reaction onset not clearly stated].Before the start of his fourth course, after 3 days of gabapentinpremedication, he had an increase in his AST level to 502 U/Land his ALT level to 500 U/L.

Gabapentin was withdrawn. The child’s laboratory valuesgradually improved.

Author comment: "A Naranjo score was calculated todetermine a causality-relation. A highly probable relationscore between use of gabapentin and high increase in hepaticenzymes was obtained."Bauters T, et al. Highly elevated liver enzymes related to the use of gabapentin ina child treated for high-risk neuroblastoma. Pediatric Blood and Cancer 60 (Suppl.S3): 116, Sep 2013. Available from: URL: http://dx.doi.org/10.1002/pbc.24719[abstract] - Belgium 803096257

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Reactions 30 Nov 2013 No. 14800114-9954/13/1480-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved